Investigation of the mechanisms involving PTFE graft occlusion and searching its pharmacotherapeutics with chymase inhibitor
| Project/Area Number |
21590295
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
JIN Denan 大阪医科大学, 医学部, 講師 (90319533)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAI Shinji 大阪医科大学, 医学部, 准教授 (80288703)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 人工血管 / PTFE / グラシル / 狭窄 / アンジオテンシンII / キマーゼ / PTEE / 血管内膜肥厚 / アンジオテンシン変換酵素(ACE) / グラフト |
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| Research Abstract |
The inside neointima formation of polytetrafluoroethylene(PTFE) grafts may be associated with the migration of outside fibroblasts to the luminal surfaces. In this study we have demonstrated that the migration of outside fibroblasts into inside of the PTFE grafts is indeed participated in the neointima formation by performing a comparative investigation with use of two different types of prosthetic vessels, the porous PTFE graft and the impermeable Grasil graft, respectively.
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Report
(4 results)
Research Products
(31 results)
