Functional characterization of candidate disease genes identified by the efficient insertional mutagenesis
| Project/Area Number |
21590303
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
SUZUKI Takeshi 金沢大学, がん進展制御研究所, 教授 (30262075)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 疾患モデルマウス / 挿入変異 / がん遺伝子 / がん分子標的 / レトロウイルス / エピジェネティクス / ゲノム不安定性 |
|---|
| Research Abstract |
Retroviral insertional mutagenesis in mice is one of the important strategies for high-throughput identification of cancer genes. Using this system, we have so far identified most of histone lysine methyltransferase genes and demethylase genes as candidate oncogenes or tumor suppressor genes. We have found that some of the enzymes are involved not only in the tumor initiation but also in the malignant tumor progression such as cell invasion
|
Report
(4 results)
Research Products
(43 results)
