Molecular basis of epigenetics on the mechanisms of sex determination and its failure

• Project/Area Number: 21590357
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human genetics
• Research Institution: Kobe University
• Principal Investigator: HOSHI Nobuhiko 神戸大学, 大学院・農学研究科, 教授 (10209223)
• Co-Investigator(Kenkyū-buntansha): SUGAWARA Teruo 小樽商科大学, 保管管理センター, 教授 (40250451) ; SAKURAGI Noriaki 北海道大学, 医学研究科, 教授 (70153963)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: エピジェネティクス / 遺伝子発現制御 / Y染色体 / 性分化 / マイクロアレイ / 発生・分化 / SRY / 性決定 / 絶対定量性リアルタイムPCR / 遺伝子発現解析 / パスウェイ解析 / メチル化 / アセチル化

Research Abstract

Testis development in mammals begins with the activation of Y-linked Sry gene, which triggers a cascade of events that lead to male pathway. To clarify the regulation mechanism of testis differentiation, we investigated the epigenetic change of the gonadal development of a unique mouse carrying Y^<pos> that showed sex reversal with true hermaphrodites, and clinical case with disorder of sex differentiation(DSD) patient. We showed that the profiles of methylation and acetylation of SRY gene and revealed some of causation of diversity of DSD.

Research Products

• [Journal Article] Molecular cytogenetic aspects of sex differentiation anomalies in the field of obstetrics and gynecology (2012)
  • Author(s): Hoshi N
  • Journal Title: Perspectives in Human Genetics Volume: (In press)
  • Peer Reviewed
• [Journal Article] Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol-exposed testicular Leydig cells (2012)
  • Author(s): Warita K, Mitsuhashi T, Tabuchi Y, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y
  • Journal Title: J Toxicol Sci Volume: 37 Pages: 287-295
  • NAID: 10030126622
  • Peer Reviewed
• [Journal Article] Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria under a physiological condition (2012)
  • Author(s): Udayanga KGS, Yamamoto K, Miyata H, Yokoo Y, Mantani Y, Takahara EI, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 74 Pages: 597-605
  • NAID: 130001879887
  • Peer Reviewed
• [Journal Article] Immunohistochemical study on the secretion of soluble Toll-like receptors from exocrine glands associated with the rat alimentary tract (2012)
  • Author(s): Mantani Y, Yokoo Y, Kamezaki A, Udayanga KGS, Takahara E, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: Histology and Histopathology Volume: (Accepted)
  • Peer Reviewed
• [Journal Article] Immunohistochemical study on the secretion of soluble Toll-like receptors from exocrine glands associated with the rat alimentary tract (2011)
  • Author(s): Mantani Y, Hoshi N, (9th), et al.(total 10)
  • Journal Title: Histol Histopathol Volume: (accepted)
• [Journal Article] Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition (2011)
  • Author(s): Udayanga KGS, Hoshi N, (8th), et al.(total 9)
  • Journal Title: Histol Histopathol Volume: 26 Pages: 811-820
• [Journal Article] Immunohistochemical study on the secretory host defense system of bactericidal peptides in rat digestive organs (2011)
  • Author(s): Yokoo Y, Hoshi N, (8th), et al.(total 9)
  • Journal Title: JVMS Volume: 73 Pages: 217-225
  • NAID: 130000444197
• [Journal Article] Immunohisto-chemical detection of phosphatidylserine and thrombospondin on the denucleating erythro-blasts in rat bone marrow (2011)
  • Author(s): Yokoyama T, Hoshi N, (8th), et al.(total 9)
  • Journal Title: JVMS Volume: 73 Pages: 949-952
• [Journal Article] Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine (2011)
  • Author(s): Mantani Y, Hoshi N, (8th), et al.(total 9)
  • Journal Title: Histol Histopathol Volume: 26 Pages: 1295-1303
• [Journal Article] Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria un a physiological condition (2011)
  • Author(s): Udayanga KGS, Hoshi N, (9th), et al.(total 10)
  • Journal Title: JVMS
• [Journal Article] Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine (2011)
  • Author(s): Mantani Y, Kamezaki A, Udayanga KGS, Takahara E, Qi W-M, Yokoyama T, Kawano J, Hoshi N, Kitagawa H
  • Journal Title: Histology and Histopathology Volume: 26 Pages: 1295-1303
  • Peer Reviewed
• [Journal Article] Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition (2011)
  • Author(s): Udayanga KGS, Miyata H, Yokoo Y, Qi W-M, Takahara E, Mantani Y, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: Histology and Histopathology Volume: 26 Pages: 811-820
  • Peer Reviewed
• [Journal Article] Immunohistochemical and Histoplanimetrical Study on the Spatial Relationship between the Settlement of Indigenous Bacteria and the Secretion of Bactericidal Peptides in Rat Alimentary Tract (2011)
  • Author(s): Yokoo Y, Miyata H, Udayanga KGS, Qi W-M, Takahara E, Mantani Y, Yokoyama T, Kawano J, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 73 Pages: 1043-1050
  • NAID: 130000677105
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection of phosphatidylserine and thrombospondin on denucleating erythroblasts in rat bone marrow (2011)
  • Author(s): Yokoyama T, Etoh T, Udayanga KGS, Takahara E, Qi WM, Warita K, Matsumoto Y, Miki T, Takeuchi Y, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 73 Pages: 949-952
  • NAID: 130000676905
  • Peer Reviewed
• [Journal Article] Molecular cytogenetic aspects of sex differentiation anomalies in the field of obstetrics and gynecology. (2011)
  • Author(s): Hoshi N
  • Journal Title: Perspectives in Human Genetics Volume: (In press)
  • Peer Reviewed
• [Journal Article] Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine. (2011)
  • Author(s): Mantani Y
  • Journal Title: Histology and Histopathology 21 Volume: (In press)
  • Peer Reviewed
• [Journal Article] Immunohistochemical study on the secretory host defense system of bactericidal peptides in rat digestive organs. (2011)
  • Author(s): Yokoo Y
  • Journal Title: Journal of Veterinary Medical Science Volume: 73 Pages: 217-225
  • Peer Reviewed
• [Journal Article] Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition. (2011)
  • Author(s): Udayanga, K.G.S.
  • Journal Title: Histology and Histopathology Volume: (Accepted)
  • Peer Reviewed
• [Journal Article] When does the sex ratio of offspring of the paternal 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) exposure decrease : in the spermatozoa stage or at fertilization? (2010)
  • Author(s): Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, TanidaT, Mitsuhashi T, Nanmori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N
  • Journal Title: Reprod Toxicol Volume: 29 Pages: 68-73
• [Journal Article] Global gene profiling and comprehensive bioinformatics analysis of a 46, XY female with pericentric inversion of the Y chromosome (2010)
  • Author(s): Mitsuhashi T, Warita K, Tabuchi Y, Takasaki I, Kondo T, Sugawara T, Hayashi F, Wang ZY, Matsumoto Y, Miki T, Takeuchi Y, Ebina Y, Yamada H, Sakuragi N, Yokoyama T, Nanmori T, Kitagawa H, Kant JA, Hoshi N
  • Journal Title: Congenit Anom Volume: 50 Pages: 40-51
  • NAID: 10029577493
• [Journal Article] Epigenetic abnormality of SRY gene in the adult XY female with pericentric inversion of the Y chromosome (2010)
  • Author(s): Mitsuhashi T, Warita K, Sugawara T, Tabuchi Y, Takasaki I, Kondo T, Hayashi F, Wang ZY, Matsumoto Y, Miki T, Takeuchi Y, Ebina Y, Yamada H, Sakuragi N, Yokoyama T, Nanmori T, Kitagawa H, Kant JA, Hoshi N
  • Journal Title: Congenit Anom Volume: 50 Pages: 85-94
  • NAID: 10029577669
• [Journal Article] Lectin histochemical detection of special sugars on the mucosal surfaces of the rat alimentary tract (2010)
  • Author(s): Yamamoto K, Hoshi N, (8th), et al.(total 9)
  • Journal Title: JVMS Volume: 72 Pages: 1119-1127
  • NAID: 130000264247
• [Journal Article] Direct effects of diethylstil-bestrol on the gene expression of the cholesterol sidechain cleavage enzyme(P450scc) in testicular Leydig cells (2010)
  • Author(s): Warita K, Mitsuhashi T, Sugawara T, Tabuchi Y, Tanida T, Wang, Z-Y, Matsumoto Y, Yokoyama T, Kitagawa H, Miki T, Takeuchi Y, Hoshi N
  • Journal Title: Life Sci Volume: 87 Pages: 281-285
• [Journal Article] Immunohistochemical and histoplanimetrical study on the spatial relationship between the settlement of indigenous bacteria and the secretion of bactericidal peptides in rat alimentary tract. (2010)
  • Author(s): Yokoo Y
  • Journal Title: Reproductive Toxicology Volume: 29 Pages: 68-73
  • Peer Reviewed
• [Journal Article] Global gene profiling and comprehensive bioinformatics analysis of a 46, XY female with pericentric inversion of the Y chromosome. (2010)
  • Author(s): Mitsuhashi T
  • Journal Title: Congenital Anomalies Volume: 50 Pages: 40-51
  • Peer Reviewed
• [Journal Article] Epigenetic abnormality of SRY gene in the XY female with pericentric inversion of the Y chromosome. (2010)
  • Author(s): Mitsuhashi T
  • Journal Title: Congenital Anomalies Volume: 50 Pages: 85-94
  • Peer Reviewed
• [Journal Article] When does the sex ratio of offspring of the paternal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decrease : in the spermatozoa stage or at fertilization? (2010)
  • Author(s): Ishihara K
  • Journal Title: Reproductive Toxicology Volume: 29 Pages: 68-73
  • Peer Reviewed
• [Journal Article] Lectin Histochemical Detection of Special Sugars on the Mucosal Surfaces of the Rat Alimentary Tract (2010)
  • Author(s): Yamamoto K
  • Journal Title: Journal of Veterinary Medical Science Volume: 72 Pages: 1119-1127
  • Peer Reviewed
• [Journal Article] Direct effects of diethylstilbestrol on the gene expression of the cholesterol side-chain cleavage enzyme (P450scc) in testicular Leydig cells. (2010)
  • Author(s): Warita K
  • Journal Title: Life Science Volume: 87 Pages: 281-285
  • Peer Reviewed
• [Journal Article] When does the sex ratio of offspring of the paternal 2,3,7,8-tetrachloro-dibenzo-p-dioxin(TCDD)exposure decrease : in the spermatozoa stage or at fertilization? (2010)
  • Author(s): Ishihara K
  • Journal Title: Reproductive Toxicology 29 Pages: 68-73
  • Peer Reviewed
• [Journal Article] Epigenetic abnormality of SRY gene in the XY female with pericentric inversion of the Y chromosome (2010)
  • Author(s): Mitsuhashi T
  • Journal Title: Congenital Anomalies 51
  • Peer Reviewed
• [Journal Article] Global gene profiling and comprehensive bioinformatics analysis of a 46,XY female with pericentric inversion of the Y chromosome (2010)
  • Author(s): Mitsuhashi T
  • Journal Title: Congenital Anomalies 50 Pages: 40-51
  • Peer Reviewed
• [Journal Article] Morphological analyses of age-related changes in C3H mouse midbrain (2009)
  • Author(s): Tanida T, Warita K, Mitsuhashi T, Ishihara K, Yokoyama T, Kitagawa H, Hoshi N
  • Journal Title: JVMS Volume: 71 Pages: 855-863
• [Journal Article] Histoplasnimetrical study on the spatial relationship of indigenous bacteria and mucosal lymphatic follicles throughout alimentary tract of rat (2009)
  • Author(s): Yamamoto K, Hoshi N, (8th), et al.(total 9)
  • Journal Title: JVMS Volume: 71 Pages: 621-630
• [Journal Article] Histoplanimetrical study on the relationship between cellular kinetics of epithelial cells and proliferation of indigenous bacteria in the rat colon (2009)
  • Author(s): Qi W-M, Hoshi N, (8th), et al.(total 9)
  • Journal Title: JVMS Volume: 71 Pages: 745-752
  • NAID: 130000134397
• [Journal Article] Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of actions : Mixed exposure to phenol, phthalate, and dioxin causes the effect of sole exposure on mouse midbrain dopaminergic nuclei to disappear (2009)
  • Author(s): Tanida T, Warita K, Ishihara K, Fukui S, Mitsuhashi T, Qi W-M, Inamoto T, Yokoyama T, Kitagawa H, Hoshi N
  • Journal Title: Toxicol Lett Volume: 189 Pages: 40-47
• [Journal Article] Specific ultrasound findings associated with fetal chromosome abnormalities (2009)
  • Author(s): Shimada S, Yamada H, Hoshi N, Kobashi G, Okuyama K, Hanatani K, Fujimoto S
  • Journal Title: Congenit Anom Volume: 49 Pages: 61-65
  • NAID: 10027388091
• [Journal Article] Specific ultrasound findings associated with fetal chromosome abnormalities (2009)
  • Author(s): Shimada S
  • Journal Title: Congenital Anomalies 49 Pages: 61-65
  • Peer Reviewed
• [Journal Article] Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action : mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei (2009)
  • Author(s): Tanida T
  • Journal Title: Toxicology Letter 189 Pages: 40-47
  • Peer Reviewed
• [Journal Article] Morphological analyses of sex differences and age-related changes in C3H mouse midbrain (2009)
  • Author(s): Tanida T
  • Journal Title: Journal of Veterinary Medical Science 71 Pages: 855-863
  • Peer Reviewed
• [Presentation] 胎子・授乳期TCDD曝露と胸腺微小環境の変化 (2011)
  • Author(s): 星信彦, 石川恭子, 須谷真己, 藤井裕香, 段上めぐみ, 木下今日子, 安田玲子, 長原大知, 谷田任司, 横山俊史, 北川浩
  • Organizer: 第87回日本解剖学会近畿支部学術集会
  • Place of Presentation: 兵庫医科大学(兵庫県)
  • Year and Date: 2011-12-03
• [Presentation] 胎子・授乳期TCDD曝露による発達中のセロトニン神経系への影響とその作用機序 (2011)
  • Author(s): 段上めぐみ, 須谷真己, 石川恭子, 藤井裕香, 木下今日子, 安田玲子, 長原大知, 谷田任司, 横山俊史, 北川浩, 星信彦
  • Organizer: 第87回日本解剖学会近畿支部学術集会
  • Place of Presentation: 兵庫医科大学(兵庫県)
  • Year and Date: 2011-12-03
• [Presentation] ラットの大腸粘膜上皮におけるToll-like receptorの発現と分泌 (2011)
  • Author(s): 万谷洋平, 亀崎青沙, Udayanga KGS, 高原英一郎, 谷田任司, 河野潤一, 横山俊史, 星信彦, 北川浩
  • Organizer: 第87回日本解剖学会近畿支部学術集会
• [Presentation] Acceleration of epithelial apoptosis through the secondary activation of mitochondria-dependent pathway in the indigenous bacteria settlement sites of rat tongue (2011)
  • Author(s): Udayanga KGS, Hoshi N, (8th), et al.
  • Organizer: 第87回日本解剖学会近畿支部学術集会
• [Presentation] ラットの呼吸器粘膜におけるToll-like receptorの発現と分泌 (2011)
  • Author(s): 亀崎青沙, 星信彦, (8th), et al.
  • Organizer: 第87回日本解剖学会近畿支部学術集会
• [Presentation] 胎子・授乳期TCDD曝露と胸腺微小環境の変化 (2011)
  • Author(s): 星信彦, et al.
  • Organizer: 第87回日本解剖学会近畿支部学術集会
• [Presentation] 胎子・授乳期TCDD曝露による発達中のセロトニン神経系への影響とその作用機序 (2011)
  • Author(s): 段上めぐみ, 星信彦(9th), et al.
  • Organizer: 第87回日本解剖学会近畿支部学術集会
• [Presentation] 雄シマヘビの生殖周期に関する一考察 (2011)
  • Author(s): 楠比呂志, 太田貴樹, 三保尚志, 鳥羽通久, 星信彦
  • Organizer: 第19回希少動物人工繁殖研究会議要旨集
• [Presentation] ラット大腸におけるToll-like receptorの局在に関する免疫組織化学的研究 (2011)
  • Author(s): 万谷洋平, Udayanga KGS, 高原英一郎, 河野潤一, 横山俊史, 星信彦, 北川浩
  • Organizer: 第152回日本獣医学会学術集会講演要旨集
• [Presentation] Acceleration of epithelial apoptosis in anterior epithelial column of filiform papilla in rat tongue by indigenous bacterial settlement (2011)
  • Author(s): Udayanga KGS, Hoshi N, (8th), et al.
  • Organizer: 第152回日本獣医学会学術集会講演要旨集
• [Presentation] ラット呼吸器系上皮におけるToll-like receptorの局在に関する免疫組織化学的研究 (2011)
  • Author(s): 亀崎青沙, 星信彦, (8th), et al.
  • Organizer: 第152回日本獣医学会学術集会講演要旨集
• [Presentation] 胎子・授乳期TCDD曝露がマウス胸腺微小環境に及ぼす影響に関する分子形態学的研究 (2011)
  • Author(s): 横山俊史, 星信彦(9th), et al.
  • Organizer: 第152回日本獣医学会学術集会講演要旨集
• [Presentation] 胎子・授乳期TCDD曝露による発達中のセロトニン神経系への影響に関する分子形態学的研究 (2011)
  • Author(s): 段上めぐみ, 星信彦(9th), et al.
  • Organizer: 第152回日本獣医学会学術集会講演要旨集
• [Presentation] バンドウイルカにおける精液一般性状および液状保存 (2011)
  • Author(s): 竹中亜紗実, 星信彦(7th), et al.
  • Organizer: 第17回日本野生動物医学会学術集会講演要旨集
• [Presentation] カリフォルニアアシカ(Zalophus californianus)の分娩時における卵巣および胎盤の性ステロイドホルモンの局在 (2011)
  • Author(s): 木下こづえ, 星信彦(7th), et al.
  • Organizer: 第17回日本野生動物医学会学術集会講演要旨集
• [Presentation] Mitochondria-dependent pathway as a final apoptosis process secondarily induced in rat esophageal epithelium under a physiological condition (2011)
  • Author(s): Udayanga KGS, Hoshi N, (8th), et al.
  • Organizer: Mitochondria, Apoptosis and Cancer Conference
  • Place of Presentation: National University of Singapore, Singapore
• [Presentation] 胎子・授乳期TCDD曝露がマウス胸腺微小環境に及ぼす影響に関する分子形態学的研究 (2011)
  • Author(s): 星信彦, 横山俊史, 石川恭子, 須谷真己, 藤井裕香, 段上めぐみ, 木下今日子, 安田玲子, 谷田任司, 北川浩
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(大阪府)
• [Presentation] 胎子・授乳期TCDD曝露による発達中のセロトニン神経系への影響に関する分子形態学的研究 (2011)
  • Author(s): 段上めぐみ, 須谷真巳, 石川恭子, 藤井裕香, 木下今日子, 安田玲子, 谷田任司, 横山俊史, 北川浩, 星信彦
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(大阪府)
• [Presentation] バンドウイルカにおける精液一般性状および液状保存 (2011)
  • Author(s): 竹中亜紗実, 柏木伸幸, 上野友香, 柿添裕香, 前園優子, 中尾建子, 楠比呂志, 星信彦
  • Organizer: 第17回日本野生動物医学会学術集会
  • Place of Presentation: 東京農工大学(東京都)
• [Presentation] カリフォルニアアシカ(Zalophus californianus)の分娩時における卵巣および胎盤の性ステロイドホルモンの局在 (2011)
  • Author(s): 木下こづえ, 木綿萌, 長原大知, 前園優子, 楠比呂志, 坪田敏男, 星信彦
  • Organizer: 第17回日本野生動物医学会学術集会
  • Place of Presentation: 東京農工大学(東京都)
• [Presentation] 雄シマヘビの生殖周期に関する一考察 (2011)
  • Author(s): 楠比呂志, 太田貴樹, 三保尚志, 鳥羽通久, 星信彦
  • Organizer: 第19回希少動物人工繁殖研究会議
  • Place of Presentation: 姫路キャッスルホテル(兵庫県)
• [Presentation] 中脳発達における環境中化学物質のAhR介在性分化制御機構の解明 (2010)
  • Author(s): 段上めぐみ
  • Organizer: 第14回日本環境ホルモン学会学術集会
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2010-12-16
• [Presentation] Changes in apoptosis process of rat esophageal epithelium with hyperproliferation of the indigenous bacteria under a physiological condition. (2010)
  • Author(s): Kankanam G.S.Udayanga
  • Organizer: 第86回日本解剖学会近畿支部学術集会
  • Place of Presentation: 大阪府立大学(大阪府)
  • Year and Date: 2010-11-27
• [Presentation] 遺伝子改変性転換マウス(Ypos)の半陰陽個体生殖腺における発生形態学的研究. (2010)
  • Author(s): 横山俊史
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] Immunohistochemical study on the apoptotic process in normal esophageal epithelium under a physiological condition. (2010)
  • Author(s): Kankanam G.S.Udayanga
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] ラット消化管附属分泌腺からの Toll-like receptor の分泌に関する免疫組織化学的研究 (2010)
  • Author(s): 万谷洋平
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] 生き物を形作るしくみエピジェネティクス-生命現象と疾患のメカニズムを理解する鍵- (2010)
  • Author(s): 星信彦
  • Organizer: エーザイ(株)安全性研究部主催講演会
  • Place of Presentation: エーザイ株式会社
  • Year and Date: 2010-09-06
• [Presentation] 生き物を形作るしくみ---エピジェネティクス--- -生命現象と疾患のメカニズムを理解する鍵- (2010)
  • Author(s): 星信彦
  • Organizer: エーザイ(株)安全性研究部主催講演会
  • Place of Presentation: エーザイ安全性研究部(茨城県)(招待講演)
  • Year and Date: 2010-09-06
• [Presentation] 性分化破綻機構の分子基盤 (2010)
  • Author(s): 星信彦
  • Organizer: 第29回日本思春期学会学術集会
  • Place of Presentation: 小樽
  • Year and Date: 2010-08-29
• [Presentation] 性分化破綻機構の分子基盤 (2010)
  • Author(s): 星信彦
  • Organizer: 第29回日本思春期学会学術集会
  • Place of Presentation: グランドパーク小樽(北海道)(招待講演)
  • Year and Date: 2010-08-29
• [Presentation] Paternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects the sex ratio of offspring at birth by change the sex ratio of fertilized egg. (2010)
  • Author(s): Ishihara K
  • Organizer: The 11th International Symposium on Spermatology Okinawa 2010 [国際学会]
  • Place of Presentation: Okinawa Convention Center
  • Year and Date: 2010-08-25
• [Presentation] 遺伝子改変・性逆転マウス Ypos の生殖腺における発生形態学的研究 (2010)
  • Author(s): 星信彦
  • Organizer: 第50回日本先天異常学会学術集会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
  • Year and Date: 2010-07-08
• [Presentation] Sry導入XXマウスにおける雄性生殖腺の形態学的解析 (2010)
  • Author(s): 横山俊史
  • Organizer: 第50回日本先天異常学会学術集会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
  • Year and Date: 2010-07-08
• [Presentation] 性分化異常症の診断と基礎. XY女性とエピジェネティクス- (2010)
  • Author(s): 星信彦
  • Organizer: 第4回神戸シンポジア
  • Place of Presentation: 神戸大学医学部附属病院
  • Year and Date: 2010-05-13
• [Presentation] 性分化異常症の診断と基礎-XY女性とエピジェネティクスー (2010)
  • Author(s): 星信彦
  • Organizer: 第4回神戸シンポジア
  • Place of Presentation: 神戸大学(兵庫県)(招待講演)
  • Year and Date: 2010-05-13
• [Presentation] 生物の雄・雌が決まるしくみ-性決定の分子遺伝学- (2010)
  • Author(s): 星信彦
  • Organizer: 大学院特別講義
  • Place of Presentation: 福井県立大学
  • Year and Date: 2010-03-02
• [Presentation] 生物の雄・雌が決まるしくみ -性決定の分子遺伝学- (2010)
  • Author(s): 星信彦
  • Organizer: 発生学懇話会
  • Place of Presentation: 福井県立大学(福井県)
  • Year and Date: 2010-03-02
• [Presentation] Paternal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) affects the sex ratio of offspring at birth by change the sex ratio of fertilized egg (2010)
  • Author(s): Ishihara K, Hoshi N(9th), et al.
  • Organizer: 11th International Symposium on Spermatology
  • Place of Presentation: Okinawa, JAPAN
• [Presentation] 遺伝子改変-性逆転マウスY^<pos>の生殖腺における発生形態学的研究 (2010)
  • Author(s): 星信彦, et al.
  • Organizer: 第50回日本先天異常学会学術集会講演要旨集
• [Presentation] Sry導入XXマウスにおける雄性生殖腺の形態学的解析 (2010)
  • Author(s): 横山俊史, 星信彦(12th), et al.
  • Organizer: 第50回日本先天異常学会学術集会講演要旨集
• [Presentation] Immunohistochemical study on the apoptotic process in normal esophageal epithelium under a physiological condition (2010)
  • Author(s): Udayanga KGS, 高原英一郎, 河野潤一, 横山俊史, 星信彦, 北川浩
  • Organizer: 第150回日本獣医学会学術集会講演要旨集
• [Presentation] ラット消化管附属分泌腺からのToll-like receptorの分泌に関する免疫組織化学的研究 (2010)
  • Author(s): 万谷洋平, Udayanga KGS, 高原英一郎, 河野潤一, 横山俊史, 星信彦, 北川浩
  • Organizer: 第150回日本獣医学会学術集会講演要旨集
• [Presentation] 遺伝子改変性転換マウス(Ypos)の半陰陽個体生殖腺における発生形態学的研究 (2010)
  • Author(s): 横山俊史, 宮本良介, 土居弘明, 田阪健, 橋本佳樹, 藤井裕香, 石川恭子, 須谷真巳, 長原大知, 三觜友子, 北川浩, 星信彦
  • Organizer: 第150回日本獣医学会学術集会講演要旨集
• [Presentation] Changes in apoptosis process of rat esophageal epithelium with hyperproliferation of the indigenous bacteria under a physiological condition (2010)
  • Author(s): Udayanga KGS, 山本教司, 宮田英典, 横尾諭, 万谷洋平, 高原英一郎, 横山俊史, 星信彦, 北川浩
  • Organizer: 第86回日本解剖学会近畿支部学術集会
• [Presentation] 性逆転症系統(Ypos)由来半陰陽マウスの生殖腺における発生形態学的研究 (2010)
  • Author(s): 横山俊史, 星信彦(12th), et al.
  • Organizer: 第86回日本解剖学会近畿支部学術集会
• [Presentation] ラット消化管付属分泌腺からのToll-like receptorの分泌に関する免疫組織化学的研究 (2010)
  • Author(s): 万谷洋平, Udayanga KGS, 高原英一郎, 河野潤一, 横山俊史, 星信彦, 北川浩
  • Organizer: 第86回日本解剖学会近畿支部学術集会
• [Presentation] 中脳発達における環境中化学物質のAhR介在性分化制御機構の解明 (2010)
  • Author(s): 段上めぐみ, 星信彦(9th), et al.
  • Organizer: 環境ホルモン学会(日本内分泌攪乱化学物質学会)第13回研究発表会要旨集
• [Presentation] TCDDによる次世代出生前性比低下と感受性との関係 (2009)
  • Author(s): 田阪健
  • Organizer: 第85回日本解剖学会近畿支部学術集会
  • Place of Presentation: 奈良県立医科大学(奈良県)
  • Year and Date: 2009-11-28
• [Presentation] マウス胎子性ライディッヒ細胞に関する発生形態学的研究 (2009)
  • Author(s): 横山俊史
  • Organizer: 第85回日本解剖学会近畿支部学術集会
  • Place of Presentation: 奈良県立医科大学(奈良県)
  • Year and Date: 2009-11-28
• [Presentation] 非終生飼育動物の命と獣医畜産系学生の心理 -代替法教育を考える- (2009)
  • Author(s): 星信彦
  • Organizer: 第22回日本動物実験代替法学会 [市民公開講座]
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2009-11-15
• [Presentation] 成獣雄マウスにおける性決定遺伝子 Sry 発現の分子学的解析 (2009)
  • Author(s): 藤井裕香
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取大学(鳥取県)
  • Year and Date: 2009-09-26
• [Presentation] マウスにおける胎子性ライディッヒ細胞の局在に関する発生形態学的研究 (2009)
  • Author(s): 横山俊史
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取大学(鳥取県)
  • Year and Date: 2009-09-26
• [Presentation] Sry 導入XXマウスにおける雄性生殖腺の形態学的解析 (2009)
  • Author(s): 土居弘明
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取大学(鳥取県)
  • Year and Date: 2009-09-26
• [Presentation] 投与雄マウスにおける感受性と次世代出生前性比との関係 (2009)
  • Author(s): 田阪健
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取大学(鳥取県)
  • Year and Date: 2009-09-25
• [Presentation] Activin A and eCG recover reproductive dysfunction induced by neonatal exposure to an estrogenic endocrine disruptor in adult male mice (2009)
  • Author(s): Warita K
  • Organizer: The 6^<th> International Symposium on Electron Microscopy in Medicine and Biology 2009
  • Place of Presentation: Kobe University(兵庫県)
  • Year and Date: 2009-09-16
• [Presentation] Localization and developmental fate of fetal Leydig cells in mouse testis (2009)
  • Author(s): 横山俊史
  • Organizer: The 6^<th> International Symposium on Electron Microscopy in Medicine and Biology 2009
  • Place of Presentation: Kobe University(兵庫県)
  • Year and Date: 2009-09-16
• [Presentation] 生物の雄・雌が決まる仕組みはどこまで解明されたか-性決定の分子遺伝学 (2009)
  • Author(s): 星信彦
  • Organizer: 第36回北陸実験動物研究会
  • Place of Presentation: 富山大学
  • Year and Date: 2009-09-05
• [Presentation] 生物の雄・雌が決まる仕組みはどこまで解明されたか-性決定の分子遺伝学 (2009)
  • Author(s): 星信彦
  • Organizer: 第36回北陸実験動物研究会
  • Place of Presentation: 富山大学(冨山県)
  • Year and Date: 2009-09-05
• [Presentation] 哺乳動物の雌雄が決まるしくみ.細胞遺伝学からエピジェネティクス (2009)
  • Author(s): 星信彦
  • Organizer: 第49回日本先天異常学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2009-06-26
• [Presentation] 哺乳動物の雌雄が決まるしくみ-細胞遺伝学からエピジェネティクス (2009)
  • Author(s): 星信彦
  • Organizer: 第49回日本先天異常学会
  • Place of Presentation: 鹿児島市民文化ホール(鹿児島県)
  • Year and Date: 2009-06-26
• [Presentation] Ultrastructural and histoplanimetrical demonstration of direct transportation of chylomicrons via subepithelial blood capillaries in rat intestinal villi (2009)
  • Author(s): Takahara E, Hoshi N, (8th), et al.
  • Organizer: The 6th International Symposium on Electron Microscopy in Medicine and Biol-ogy
  • Place of Presentation: Kobe, Japan
• [Presentation] Ultrastructural and immunohistoche-mical study on the apoptotic process of intestinal epithelial cells in rats (2009)
  • Author(s): Nishida M, Hoshi H, (8th), et al.
  • Organizer: The 6th International Symposium on Electron Microscopy in Medicine and Biol-ogy
  • Place of Presentation: Kobe, Japan
• [Presentation] Immunohistochemical study on the toll-like receptor expression in villous columnar epithelial cells of rat small intestine (2009)
  • Author(s): Mantani Y, Hoshi N, (8th), et al.
  • Organizer: The 6th International Symposium on Electron Microscopy in Medicine and Biol-ogy
  • Place of Presentation: Kobe, Japan
• [Presentation] Ultrastructural study on the indigenous bacteria in the lumen of rat intestine (2009)
  • Author(s): Ito E, Hoshi N, (9th), et al.
  • Organizer: The 6th International Symposium on Electron Microscopy in Medicine and Biol-ogy
  • Place of Presentation: Kobe, Japan
• [Presentation] Scanning electron microscopic study on the persorption mechanism of large antigenic particulates from small intestinal lumen in rats (2009)
  • Author(s): Fukui Y, Hoshi N, (9th), et al.
  • Organizer: The 6th International Symposium on Electron Microscopy in Medicine and Biol-ogy
  • Place of Presentation: Kobe, Japan
• [Presentation] Activin A and ECG recover reproductive dysfunction induced by neonatal exposure to an estrogenic endocrine disruptor in adult male mice (2009)
  • Author(s): Warita K, Mitsuhashi T, Yokoyama T, Matsumoto Y, Kitagawa H, Miki T, Takeuchi Y, Hoshi N
  • Organizer: The 6th International Symposium on Electron Microscopy in Medicine and Biol-ogy
  • Place of Presentation: Kobe, Japan
• [Presentation] Localization and developmental fate of fetal Leydig cells in mouse testis (2009)
  • Author(s): Yokoyama T, Aoki K, Ishihara K, Mitsuhashi T, Warita K, Mitsuhashi T, Kitagawa H, Hoshi N
  • Organizer: The 6th International Symposium on Electron Microscopy in Medicine and Biol-ogy
  • Place of Presentation: Kobe, Japan
• [Presentation] ラットの腸管上皮におけるアポトーシス発現に関する超微形態学的研究 (2009)
  • Author(s): 西田美穂, 伊藤栄理, 宮田英典, 平野晶子, 斉旺梅, Udayanga KGS, 横山俊史, 星信彦, 北川浩
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] ラット小腸の粘膜上皮におけるToll-like receptorの発現に関する免疫組織化学的研究 (2009)
  • Author(s): 万谷洋平, Udayanga KGS, 横尾諭, 宮田英典, 河野潤一, 横山俊史, 星信彦, 北川浩
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] ラット腸管の濾胞被蓋上皮における上皮細胞の動態に関する計量免疫組織化学的研究 (2009)
  • Author(s): 宮田英典, 平野晶子, 斉旺梅, 横尾諭, Udayanga KGS, 横山俊史, 星信彦, 北川浩
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] ラットの腸管内腔に存在する常在細菌の超微形態学的観察 (2009)
  • Author(s): 伊藤栄理, 星信彦, (8th), et al.
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] Immunohistochemical study on the apoptosis process in rat epidermis (2009)
  • Author(s): Udayanga KGS, Hoshi N, (8th), et al.
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] アカネズミのAhR遺伝子多型とダイオキシン曝露の影響に関する分子形態学的評価 (2009)
  • Author(s): 須谷真巳, 星信彦(13th), et al.
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] 投与雄マウスにおける感受性と次世代出生前性比との関係 (2009)
  • Author(s): 田阪健, 星信彦(10th), et al.
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] 成獣雄マウスにおける性決定遺伝子Sry発現の分子学的解析 (2009)
  • Author(s): 藤井裕香, 星信彦(10th), et al.
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] マウスにおける胎子性ライディッヒ細胞の局在に関する発生形態学的研究 (2009)
  • Author(s): 横山俊史, 青木香保里, 三觜友子, 石原可奈, 谷田任司, 北川浩, 星信彦
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] Sry導入XXマウスにおける雄性生殖腺の形態学的解析 (2009)
  • Author(s): 土居弘明, 宮本良介, 田阪健, 橋本佳樹, 三觜友子, 石原可奈, 谷田任司, 横山俊史, 北川浩, 星信彦
  • Organizer: 第148回日本獣医学会学術集会講演要旨集
• [Presentation] Apoptosis process in epidermal epithelial cells of rat under a physiological condition (2009)
  • Author(s): Udayanga KGS, Hoshi N, (8th), et al.
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Presentation] ラット腸管の常在細菌と寒天平板培養細菌の超微形態学的比較検討 (2009)
  • Author(s): 伊藤栄理, 星信彦, (7th), et al.
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Presentation] ラット小腸および大腸の粘膜リンパ組織における上皮細胞の動態の特性 (2009)
  • Author(s): 宮田英典, 平野晶子, 斉旺梅, 横尾諭, Udayanga KGS, 横山俊史, 星信彦, 北川浩
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Presentation] ラット腸管の上皮細胞における経時的形態学的変化とアポトーシスの進行に関する免疫組織化学的研究 (2009)
  • Author(s): 西田美穂, 伊藤栄理, 宮田英典, 平野晶子, 斉旺梅, Udayanga KGS, 横山俊史, 星信彦, 北川浩
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Presentation] ラット小腸腸絨毛におけるToll-like Receptorの発現 (2009)
  • Author(s): 万谷洋平, Udayanga KGS, 横尾諭, 宮田英典, 河野潤一, 横山俊史, 星信彦, 北川浩
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Presentation] アカネズミのAhR遺伝子多型におけるダイオキシン曝露の影響 (2009)
  • Author(s): 須谷真巳, 星信彦(13th), et al.
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Presentation] TCDDによる次世代出生前性比低下と感受性との関係 (2009)
  • Author(s): 田阪健, 星信彦(10th), et al.
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Presentation] マウス胎子性ライディッヒ細胞に関する発生形態学的研究 (2009)
  • Author(s): 横山俊史, 青木香保里, 三觜友子, 石原可奈, 谷田任司, 北川浩, 星信彦
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Presentation] Sry導入XXマウスにおける雄性生殖腺の生後変化 (2009)
  • Author(s): 土居弘明, 宮本良介, 田阪健, 橋本佳樹, 三觜友子, 石原可奈, 谷田任司, 横山俊史, 北川浩, 星信彦
  • Organizer: 第85回日本解剖学会近畿支部学術集会
• [Book] Molecular cytogenetic aspects of sex differentiation anomalies in the field of obstetrics and gynecology (2011)
  • Author(s): Hoshi N, et al.(total 9)
  • Publisher: Perspectives in Human Genetics, India.(in press)
• [Book] 獣医組織学 (2011)
  • Author(s): 星信彦
  • Publisher: 学窓社
• [Book] 環境学入門 (2011)
  • Author(s): 星信彦
  • Publisher: 丸善出版株式会社
• [Book] 獣医組織学改訂第5版 (2011)
  • Author(s): 星信彦
  • Total Pages: 361
  • Publisher: 学窓社
• [Book] 獣医組織学[第五版] (2011)
  • Author(s): 星信彦
  • Total Pages: 361
  • Publisher: 学窓社