Aberrant expression of Notch ligands in multiple myeloma

• Project/Area Number: 21590371
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kochi University
• Principal Investigator: TAKEUCHI Tamotsu 高知大学, 教育研究部・医療学系, 准教授 (50226990)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 多発性骨髄腫 / 骨髄微小環境 / ミエローマニッチ / 多発性骨髄腫瘍 / 癌間質 / Notch / TMEM207 / ユビキチン / Notch ligand / 低酸素状態 / Notch ligands / 細胞間相互作用 / Ogfod1

Research Abstract

In the present study, we examined the pathobiological property of Notch system in multiple myeloma, especially so called" myeloma niche", which contribute the growth of myeloma cells thorough direct interaction or through humoral factors. The author found that several factors, i. e. TMEM207, were overexpressed by aberrant Notch functions. TMEM207 appeared to bind to WWOX, a tumor suppressor factor, and impaired the function of its tumor suppressor function.

Research Products

• [Journal Article] A WWOX binding molecule, Transmembrane Protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma (2012)
  • Author(s): Takeuchi T, Adachi Y, Nagayama T.
  • Journal Title: Carcinogenesis Volume: 33 Pages: 548-554
  • Peer Reviewed
• [Journal Article] Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma (2011)
  • Author(s): Takeuchi T, Adachi Y, Nagayama T.
  • Journal Title: Anal Cell Pathol(Cell Oncol.) Volume: 34 Pages: 113-121
  • Peer Reviewed
• [Journal Article] Co-Existence of Pregnancy-Like and Cystic Hypersecretory Hyperplasia with Invasive Lobular Carcinoma (2011)
  • Author(s): Takeuchi T, Tsuzuki H, Numoto S, Furihata M.
  • Journal Title: Onkologie Volume: 34 Pages: 448-450
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-11 overexpressed in lobular carcinoma cells of the breast promotes anoikis resistance (2011)
  • Author(s): Takeuchi, T, Adachi Y, Nagayama T, Furihata, M.
  • Journal Title: Virchow Archiv Volume: 459 Pages: 291-297
  • Peer Reviewed
• [Journal Article] Evaluation of BPA uptake in clear cell sarcoma(CCS) in vitro and development of an in vivo model of CCS for BNCT studies (2011)
  • Author(s): Fujimoto T, Andoh T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Sonobe H, Epstein AL, Akisue T, Kirihata M, Kurosaka M, Fukumori Y, Ichikawa H.
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1713-1716
  • Peer Reviewed
• [Journal Article] Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma (2011)
  • Author(s): Takeuchi T, Adachi Y, Nagayama T
  • Journal Title: Anal Cell Pathol Volume: 34 Pages: 113-121
  • Peer Reviewed
• [Journal Article] T-cadherin modulates tumor-associated molecules in gallbladder cancer cells (2010)
  • Author(s): Adachi Y, Takeuchi T, Nagayama T, Furihata M.
  • Journal Title: Cancer Invest Volume: 28 Pages: 120-126
  • Peer Reviewed
• [Journal Article] Nedd4L modulates the transcription of metalloproteinase-1 and-13 genes to increase the invasive activity of gallbladder cancer (2010)
  • Author(s): Takeuchi T, Adachi Y, Nagayama T, Furihata M.
  • Journal Title: Int J Exp Pathology Volume: 92 Pages: 79-86
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane (2010)
  • Author(s): Takeuchi T, Iwasaki S, Miyazaki J, Nozaki Y, Takahashi M, Ono M, Saibara T, Furihata M.
  • Journal Title: Int J Clin Exp Pathol Volume: 3 Pages: 634-639
  • Peer Reviewed
• [Journal Article] Pseudosarcomatous proliferation of cx43-and kit-expressing interstitial cell in the urinary bladder (2010)
  • Author(s): Takeuchi T, Tanimura M, Shimamoto T, Yasuda M, Furihata M.
  • Journal Title: Patholog Res Int Volume: Dec22 Pages: 961325-961325
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane. (2010)
  • Author(s): Takeuchi T, et al.
  • Journal Title: Int J Clin Exp Pathol. Volume: 3 Pages: 634-639
  • Peer Reviewed
• [Journal Article] T-cadherin modulates tumor-associated molecules in gallbladder cancer cells (2010)
  • Author(s): Adachi, Y., et al.
  • Journal Title: Cancer Invest 28 Pages: 120-126
  • Peer Reviewed
• [Journal Article] Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer (2009)
  • Author(s): Adachi Y, Takeuchi T, Nagayama T, Ohtsuki Y, Furihata M.
  • Journal Title: FEBS Lett Volume: 583 Pages: 430-436
  • Peer Reviewed
• [Journal Article] Systemic IgG4-related lymphadenopathy : a clinical and pathologic comparison to multicentric Castleman' s disease (2009)
  • Author(s): Sato Y, Kojima M, Takata K, Morito T, Asaoku H, Takeuchi T, Mizobuchi K, Fujihara M, Kuraoka K, Nakai T, Ichimura K, Tanaka T, Tamura M, Nishikawa Y, Yoshino T.
  • Journal Title: Mod. Pathol Volume: 22 Pages: 589-599
  • Peer Reviewed
• [Journal Article] Human leukocyte antigen-G, a ligand for the natural killer receptor KIR2DL4, is expressed by eutopic endometrium only in the menstrual phase (2009)
  • Author(s): Kawashima M, Maeda N, Adachi Y, Takeuchi T, Yamamoto Y, Izumiya C, Hayashi K, Furihata M, Udaka K, Fukaya T.
  • Journal Title: Fertil Steril Volume: 91 Pages: 343-349
  • Peer Reviewed
• [Journal Article] Analysis of Aurora B kinase in non-Hodgkin lymphoma (2009)
  • Author(s): Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, Koeffler P, Yokoyama A.
  • Journal Title: Lab Invest Volume: 89 Pages: 1364-1373
  • Peer Reviewed
• [Journal Article] Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer (2009)
  • Author(s): Adachi, Y., et al.
  • Journal Title: FEBS Lett 583 Pages: 430-436
  • Peer Reviewed
• [Journal Article] Systemic IgG4-related lymphadenopathy : a clinical and pathologic comparison to multicentric Castleman's disease (2009)
  • Author(s): Sato, Y., et al.
  • Journal Title: Mod.Pathol 22 Pages: 589-599
  • Peer Reviewed
• [Journal Article] Pseudosarcomatous proliferation of Cx43- and KIT-expressing interstitial cell in the urinary bladder
  • Author(s): Takeuchi T, et al.
  • Journal Title: Pathology Res.Int Volume: (In press)
  • Peer Reviewed
• [Journal Article] Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinema
  • Author(s): Takeuchi T, et al.
  • Journal Title: Analytic cellular pathology Volume: (In press)
  • Peer Reviewed
• [Presentation] 腫瘍抑制因子WWOX機能抑制による胃癌浸潤メカニズム (2011)
  • Author(s): 竹内保・降幡睦夫
  • Organizer: 第100回日本病理学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-28
• [Presentation] MHC class II dependent infiltration of tumor specific Th cells into solid tumors (2010)
  • Author(s): Noguchi Y, Komatsu T, Kato E, Takeuchi T, Udaka K
  • Organizer: 14th International Congress of Immunology Kobe
  • Year and Date: 2010-08-22
• [Presentation] Tumor specific Th cells promote an active recruitment of CTLs into solid tumors (2010)
  • Author(s): Komatsu T, Yano A, Noguchi Y, Takeuchi T, Udaka K
  • Organizer: 14th International Congress of Immunology Kobe
  • Year and Date: 2010-08-22
• [Presentation] WT1 peptide immunotherapy for prostate cancer patients (2010)
  • Author(s): Iiyama T, Hirachi Y, Uemura A, Kataoka S, Adachi Y, Takeuchi T, Kitajima K, Kitajima A, Nakaishi M, Matsushita J, Okada T, Shuin T, Udaka K
  • Organizer: 14th International Congress of Immunology Kobe
  • Year and Date: 2010-08-22
• [Presentation] 胃印環細胞癌の浸潤、リンパ節転移に関係する膜たんぱく質TMEM207の解析 (2010)
  • Author(s): 竹内保・降幡睦夫
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27
• [Presentation] 胃印環細胞癌の浸潤、リンパ節転移に関係する膜たんぱく質TMEM207の解析 (2010)
  • Author(s): 竹内保
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京(京王プラザホテル)
  • Year and Date: 2010-04-27
• [Presentation] A paracrine C1qTNF6/ T-cadherin signaling pathway contribute to neovascularization in hepatocellular carcinoma (2009)
  • Author(s): 竹内保・降幡睦夫
  • Organizer: 第68回日本癌学会ワークショップ
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 乳癌間質低酸素状態におけるNotch system活性化メカニズムの検討 (2009)
  • Author(s): 竹内保・降幡睦夫
  • Organizer: 第98回日本病理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-01
• [Book] 明細胞肉腫 (2011)
  • Author(s): 園部宏、竹内保
  • Publisher: 文光堂
• [Book] 分子生物の項(細胞接着因子) (2009)
  • Author(s): 竹内保
  • Publisher: 医学書院
• [Remarks] Takeuchi T Atlas of Genetics and Cytogenetics in Oncology and Haematology(Editor-in-Chief : Jean-Loup Huret) Mib2 Genetics DIM, France, 2009
• [Remarks] Takeuchi T Encyclopedia of Cancer, 2nd ed.(Schwab, Manfred Ed.) Skeletrophin 2009 Springer
• [Remarks] Furihata M and Takeuchi T Encyclopedia of Cancer, 2nd ed.(Schwab, Manfred Ed.) Gleason score 2009 Springer