| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The mechanism underlying the aberrant miRNA expression in gastric carcinogenesis remains unclear. Here we observed that miR-181c and miR-212 were epigenetically regulated in gastric cancers(GCs). Methylation status at the CpG island of miR-181c was strongly related to its expression levels. Over-expression of these miRNAs significantly reduced cell proliferation, suggesting a tumor suppressive function. Moreover, miR-9 expression was high in GCs with lymph node metastasis and inversely associated with CDX2 expression. Thus altered expression of these miRNAs may contribute to gastric carcinogenesis.
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