Klotho-dependent protective mechanisms of hyperexcitability of the brain

Research Project

Project/Area Number	21590418
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Experimental pathology
Research Institution	Kyoto University (2009, 2011) Foundation for Biomedical Research and Innovation (2010)
Principal Investigator	MURATA Miyahiko 京都大学, 再生医科学研究所, 教務補佐員 (50222435)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	動物 / カルシウム / 恒常性 / 興奮性 / 脳脊髄液 / 腎臓 / クロトー
Research Abstract	Calcium homeostasis of body fluid is now recognized to be maintained by hormonal regulation. However, prior to these hormonal regulations, the calcium elevation occured in response to artificial calcium decrease. The measurement of calcium revealed that low concentration of calcium in the blood was normalized during the passage of the kidney rapidly, in a second-order. This response was independent of PTH and vitamin D secretion and was therefore tissue-autonomous. This homeostatic effct is impaied in the & alpha-klotho homo and hetero knockout mice.

Report

(4 results)