Sharing pathogenic mechanism between non-alcoholic steatohepatitis and primary biliary cirrhosis
| Project/Area Number |
21590433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Toyama |
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Principal Investigator |
TSUNEYAMA Koichi 富山大学, 大学院・医学薬学研究部(医学), 准教授 (10293341)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 疾患モデル動物 / NASH, PBC,酸化ストレス / NASH / PBC / 酸化ストレス |
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| Research Abstract |
Pathological characteristics of non-alcoholic steatohepatitis(NASH) and primary biliary cirrhosis(PBC) were examined. Obese female NASH patients of the older age have a tendency to show PBC-mimicking biliary damages, portal inflammation as well as autoantibodies. Similar pathological changes were observed in older aged female NASH mice model. In contrast, NASH features were not observed in any PBC model mice. In visceral fat of NASH mice model, TNF-αor IL6-positive macrophages aggregation was detected. In drug-induced liver injury mice model, estrogen pretreatment reduced inflammatory severity, while progesterone pretreatment enhanced it. We hypothesized that effects of inflammatory cytokines in the obesity women were enhanced by hormonal imbalance, and easy to cause biliary damages and portal inflammation.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens : Interobserver agreement.2010
Author(s)
Nakanuma Y, Zen Y, Harada K, Sasaki M, Nonomura A, Uehara T, Sano K, Kondo F, Fukusato T, Tsuneyama K, et al
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Journal Title
Pathol Int. 60(3)
Pages: 167-174
NAID
Related Report
Peer Reviewed
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[Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour.2009
Author(s)
Ito M, Nakashima A, Hidaka T, Okabe M, Bac ND, Ina S, Yoneda S, Shiozaki A, Sumi S, Tsuneyama K, et al.
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Journal Title
J Reprod Immunol. 84(1)
Pages: 75-85
Related Report
Peer Reviewed
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