Epitope of causative microorganism of primary biliary cirrhosis
| Project/Area Number |
21590494
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Juntendo University |
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Principal Investigator |
KIKUCHI Ken 順天堂大学, 医学部, 准教授 (60214748)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 原発性胆汁性肝硬変 / 抗原エピトープ / ヒストン様タンパク / Streptococcus intermedius / 比較ゲノム解析 / 分子模倣 / 原発性胆汁性肝硬変(PBC) / microcompartment / Strptococcus intermedius / histone-like protein / gp210 |
|---|
| Research Abstract |
The epitope of the anti-gp210 antibody, which contributes to the progression of primary biliary cirrhosis(PBC), was conserved in histone-like protein of Streptococcus intermedius(SI) in mouse PBC model. SI was more frequently isolated from gingivitis lesions of PBC patients than those in controls. However, there were no significant differences of virulence factors and genetic backgrounds between strains from patients with PBC and control.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis2012
Author(s)
Haruta I, Kikuchi K, Nakamura M, Miyakawa H, Hirota K, Kato H, Miyakawa H, Shibata N, Miyake Y, Hashimoto E, Shiratori K, Yagi J
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Journal Title
J. Clin. Immunol
Volume: (e-published)
Related Report
Peer Reviewed
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[Journal Article] Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation2010
Author(s)
Haruta I, Kikuchi K, Hashimoto E, Nakamura M, Miyakawa H, Hirota K, Shibata N, Kato H, Arimura Y, Kato Y, Uchiyama T, Nagamune H, Kobayashi M, Miyake Y, Shiratori K, Yagi J
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Journal Title
Lab. Invest
Volume: 90
Pages: 577-588
Related Report
Peer Reviewed
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