The co-stimulatory effect of CD28 and ICOS on T cell response

• Project/Area Number: 21590541
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Tokyo University of Science
• Principal Investigator: ABE Ryo 東京理科大学, 生命科学研究所, 教授 (20159453)
• Co-Investigator(Kenkyū-buntansha): OGAWA Shuhei 東京理科大学, 生命医科学研究所, 助教 (20385553)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 獲得免疫 / 免疫学 / T細胞 / 補助シグナル / シグナル伝達 / 移植 / アポトーシス / サイトカイン / 寛容

Research Abstract

In this study, we examined the functional role of CD28 and ICOS-mediated costimulation in T cell responses using mutant CD28 and ICOS transgenic mice.

Research Products

• [Journal Article] The transcription factor AP-1 is involved in ICOS gene expression downstream of TCR/CD28 signaling and cytokine receptor signaling (2012)
  • Author(s): Watanabe M, Nakajima S, Kazunobu O, Ogawa S, Yamashita M, Nakayama T, Murakami Y, Tanabe K, Abe R
  • Journal Title: Eur J Immunol Volume: 42 Issue: 7 Pages: 1850-1862
  • DOI: 10.1002/eji.201141897
  • Peer Reviewed
• [Journal Article] Amelioration of cardiac allograft deterioration by interleukin-6 receptor signaling disruption in mice (2012)
  • Author(s): Iida S, Omoto K, Kanemitsu I, Setoguchi K, Ishida H, Tanabe K, Suzuki T, Tashiro Y, Kishimoto H, Abe R
  • Journal Title: Experimental and Clinical transplantation
  • Peer Reviewed
• [Journal Article] The transcription factor AP-1 is involved in ICOS gene expression downstream of TCR/CD28 signaling and cytokins receptor signaling (2012)
  • Author(s): Watanabe, M., Nakajima, S., Ohnuki, K., Ogawa, S., Yamashita, M., Nakayama, T., Murakami, Y., Tanabe, K., Abe, R.
  • Journal Title: Eur.J.Immunol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Ex vivo-expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin grafts (2011)
  • Author(s): Yamano T, Watanabe S, Hasegawa H, Suzuki T, Abe R, Tahara H, Nitta T, Ishimaru N, Sprent J, Kishimoto H
  • Journal Title: Blood Volume: 117(9) Pages: 2640-8
  • Peer Reviewed
• [Journal Article] Potential role of host effector memory CD8+T cells in marrow rejection after mixed chimerism induction in cynomolgus monkeys (2010)
  • Author(s): Setoguchi K, Kishimoto H, Kobayashi S, Shimmura H, Ishida H, Toki D, Suzuki T, Ohnuki K, Tate Y, Fujioka S, Abe R, Tanabe K
  • Journal Title: Transpl Immunol Volume: 23(4) Pages: 194-203
  • Peer Reviewed
• [Journal Article] Potential role of host effector memory CD8+ T cells in marrow rejection after mixed chimerism induction in cynomolgus monkeys. (2010)
  • Author(s): Setoguchi, K., Kishimoto, H., Kobayashi S., Shimmura H., Ishida, H., Toki, D., Suzuki, T., Ohnuki, K., Tate, Y., Fujioka, S., Abe, R., Tanabe, K.
  • Journal Title: Transpl.Immunol. Volume: 23 Pages: 194-203
  • Peer Reviewed
• [Journal Article] CD8^+T細胞の活性化とCD28 (2010)
  • Author(s): 小川修平
  • Journal Title: 臨床免疫・アレルギー科 Volume: 53(6) Pages: 562-568
• [Journal Article] Suppression of Con A-induced hepatitis induction in ICOS-deficient mice (2010)
  • Author(s): 渡辺志保, 大貫和信, 原泰志, 石田康生, 五十嵐美徳, 小川修平, 岸本英博, 田邉一成, 安部良
  • Journal Title: Immunology letters 128 Pages: 51-58
  • Peer Reviewed
• [Journal Article] Suppression of Con A-induced hepatitis induction in ICOS-deficient mice (2009)
  • Author(s): Watanabe S, Ohnuki K, Hara Y, Ishida Y, Ikarashi Y, Ogawa S, Kishimoto H, Tanabe K, Abe R
  • Journal Title: Immunol Lett
  • Peer Reviewed
• [Presentation] The functional relationship between CD28 YMNM and PxxP motifs in CD28-mediated costimulation (2011)
  • Author(s): Ogawa S., Sakurai Y., Katayama A., Shigeta M., Yoshida N., Horibe C., Gamoh S., Ohtsuka S., Maruyama H., Iida M., Hiruta T., and Abe R.
  • Organizer: 第40回日本免疫学会総会
• [Presentation] CD28-mediated signaling through tyrosine phosphorylation-dependent and -independent pathways (2011)
  • Author(s): Ogawa, S., Sakurai, Y., Katayama, A, Kishimoto, H., T., Abe, R
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都平安ホテル
• [Presentation] The role of Interleukin-7 on maintenance and functional alteration of tumor antigen specific CTLs, accompanied by lymphopenia induced proliferation (2011)
  • Author(s): Suzuki, T., Kishimoto, H., Abe, R.
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都平安ホテル
• [Presentation] The functional relationship between CD28 YMNM and PxxP motifs in CD28-mediated costimulation (2011)
  • Author(s): Ogawa, S., Sakurai, Y., Katayama, A., Shigeta, M., Yoshida, N., Horibe, C., Gamoh S., Ohtsuka, S., Maruyama, H., Iida, M., Hiruta, T., Abe, R
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
• [Presentation] The Role of IL7 signaling for the maintenance and functional alteration of IL7Ra+ early effector CD8+ T cells during the anti-tumor immune response, accompanied by lymphopenia induced proliferation (2011)
  • Author(s): Suzuki, T., Kishimoto, H., Abe, R
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
• [Presentation] CD28細胞内領域とアダプター分子Gads SH2及びGrb2 SH2との分子間相互作用解析 (2011)
  • Author(s): 肥後邦武、砂橋朗進、森井尚之、池上貴久、伊倉貞吉、伊藤暢聡、安部良、織田昌幸
  • Organizer: 第11回日本蛋白質科学会年会
  • Place of Presentation: ホテル阪急エキスポパーク
• [Presentation] T細胞補助シグナル:ベンチから臨床へ (2010)
  • Author(s): 安部良
  • Organizer: 第83回発生工学・疾患モデル研究会
  • Place of Presentation: 東京大学医科学研究所
  • Year and Date: 2010-10-22
• [Presentation] Different requirements for induction of the CD28-mediated signal transduction pathway in naive vs activated T cells (2010)
  • Author(s): Ogawa S., Watanabe S., Inutake Y., Sakurai Y., Katayama A., and Abe R.
  • Organizer: 14^<th> International Congress of Immunology
• [Presentation] Central tolerance induction by adoptive transfer of donor dendritic cells. (2010)
  • Author(s): Yamano, Y., Goto, M., Abe, R., Kishimoto, H.
  • Organizer: 97^<th> Annual Meeting The American Association of Immunologists.
  • Place of Presentation: Baltimore, Maryland, USA
• [Presentation] Molecular interactions of CD28 cytoplasmic domains with Gads and its domain-deficient mutants. (2010)
  • Author(s): Sunahashi, T., Nakamura, K., Morii, M., Noda, M., Uchiyama, S., Higo, K., Abe, R., Fukui K., Oda, M
  • Organizer: The 10^<th> Annual Meeting of the Protein Science Society of Japan
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] Antigen-specific CD4+ effector T cells : Analysis of factors regulating clonal expansion, cytokine production and high dose suppression (2010)
  • Author(s): Ohnuki, K., Akashi, T., Murasaki, S., Kobayashi, S., Watanabe S., Ogawa, S., Abe, R.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場
• [Presentation] Localization of Bcl10 during T-APC interaction. (2010)
  • Author(s): Miura, S., Ohnuki, K., Watanabe, S., Kobayashi, S., Ogawa, S., Abe, R.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場
• [Presentation] Ex-vivo expanded DCs traffic to allogenic recipient thymus and induced donor specific central tolerance. (2010)
  • Author(s): Yamano, T., Abe, R., Kishimoto, H.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場
• [Presentation] The requirement for IL7 signaling in the maintenance of IL7Rα+ early effector CD8+ T cells during the anti-tumor immune response induced by lymphopenia-induced proliferation and CD28 signaling. (2010)
  • Author(s): Suzuki, T., Ishizaki, J., Oshima, Y, Kishimoto, H., Abe, R.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場
• [Presentation] Effect of lymphopenia-induced proliferation on central tolerance in mixed hematopoietic chimeras. (2010)
  • Author(s): Tashiro, Y., Hasegawa, H., Motoi, Y., Watanabe, S., Kobayashi S., Suzuki, T., Kishimoto, H., Abe, R.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場
• [Presentation] Different requirements for induction of the CD28-mediated signal transduction pathway in naive vs activated T cells. (2010)
  • Author(s): Ogawa, S., Watanabe, S., Inutake, Y., Sakurai, Y., Katayama, A., Abe, R.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場
• [Presentation] Regulation of CD28 tyrosine phosphorylation and functions induced by its interaction with natural ligand. (2010)
  • Author(s): Katayama, A., Sakurai, Y., Ogawa, S., Watanabe, S., Abe, R.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場
• [Presentation] Role of CD28 expressed on host T cells in pathogenesis of chronic GVHD. (2010)
  • Author(s): Akieda, Y., Ogawa, S., Fujimura, K., Oka, T., Watanabe, S., Hara, Y., Kishimoto, H., Abe, R.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場
• [Presentation] Ex-vivo expanded DCs home to the thymus and induce donor-specific negative selection. (2010)
  • Author(s): Kishimoto, H., Yamano, T., Watanabe, S., Hasegawa, H., Suzuki, T., Abe, R., Tahara, H., Nitta, T., Ishimaru, N., Sprent, J.
  • Organizer: 第20回Kyoto T Cell Conference.
  • Place of Presentation: 京都芝蘭会館
• [Presentation] The role of IL7 signaling for the expansion of IL7Rα+ early effector CD8+ T cells during the anti-tumor immune response accompanied by lymphopenia induced proliferation. (2010)
  • Author(s): Suzuki, T., Kishimoto, H., Abe, R.
  • Organizer: 第20回Kyoto T Cell Conference.
  • Place of Presentation: 京都芝蘭会館
• [Presentation] Induction of anti-tumor immune response by combination therapy with chemotherapy and adoptive transfer of T cells. (2010)
  • Author(s): Ishizaki, J., Abe, R., Kishimoto H., Suzuki, T., Tanabe, K.
  • Organizer: 69^<th> Annual Meeting of the Japanese Cancer As sociation.
  • Place of Presentation: 大阪国際会議場 リーガロイヤルホテル大阪
• [Presentation] 骨髄キメラ誘導時のアロ骨髄生着段階における骨髄中ドナーT細胞の役割 (2010)
  • Author(s): 柏原裕樹、岸本英博、鈴木利宙、田邊一成、飯田祥一、安部良
  • Organizer: 第46回日本移植学会
  • Place of Presentation: 京都みやこめっせ
• [Presentation] The effect of CD28 mediated costimulation in response of naive and memory T cells (2009)
  • Author(s): Ogawa S., Inutake Y., Sakurai Y., Miura Y., Katayama A., Higo K., Watanabe S., Kishimoto H., Abe R
  • Organizer: 第39回日本免疫学会総会
• [Presentation] The tyrosine phosphprylation of CD28 and CD28 mediated costimulation (2009)
  • Author(s): 小川修平, 桜井雄一, 渡辺政志, 渡辺志保, 岸本英博, 安部良
  • Organizer: Kyoto T Cell Conference 2009
  • Place of Presentation: 京都芝蘭会館
• [Presentation] Role of the CD28 signal expressed on host T cell in pathogenesis of chronic GVHD.n (2009)
  • Author(s): 藤村建午, 小川修平, 岡貴弘, 龝枝佑紀, 渡辺志保, 原泰志, 岸本英博, 安部良
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] The effect of CS28 mediated costimulation in response of naive and memory T cells (2009)
  • Author(s): 小川修平, 犬竹優, 桜井雄一, 三浦幸子, 片山愛子, 肥後邦武, 渡辺志保, 岸本英博, 安部良
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Elucidation of the mechanism of CD28 tyrosine phosphorylation and analysis of its phosphorylation-dependent and -in dependent functions (2009)
  • Author(s): 桜井雄一, 小川修平, 犬竹優, 片山愛子, 渡辺志保, 岸本英博, 安部良
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] The role of the CD28 transmembrane region in IL-2 production (2009)
  • Author(s): 徳丸正輝, 小川修平, 鈴木利宙, 原泰志, 原田陽介, 岸本英博, 安部良
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Contribution of TCR- and CD28-mediated signals to NF-kappa B action (2009)
  • Author(s): 犬竹優, 竹田圭, 三浦幸子, 桜井雄一, 小川修平, 岸本英博, 安部良
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Gadsの精製とCD28細胞質内ドメインとの相互作用 (2009)
  • Author(s): Higo, K., Takahashi, J., Oda, M., Morii, M., Ikura, T., Itoh, N., Azuma, T., Abe, R.
  • Organizer: 第47回 日本生物物理学会年会
  • Place of Presentation: アスティ徳島
• [Book] 免疫力アップジュース (2011)
  • Author(s): 安部良、大越郷子
  • Publisher: (株)西東社
• [Book] T細胞の活性化におけるTCRシグナルとCD28シグナル (2011)
  • Author(s): 安部良、三浦幸子、竹田圭
  • Total Pages: 9
  • Publisher: 臨床免疫・アレルギー科、科学評論社
• [Book] 補助シグナル分子(CD28/CD80、86、CTLA-4)、Animal Models免疫疾患-疾患モデルの作製と利用 (2011)
  • Author(s): 安部良
  • Total Pages: 5
  • Publisher: (株)エル・アイ・シー
• [Remarks]