Significance of the vasoactive substances and interaction between inflammation and coagulation in DIC
Project/Area Number |
21590614
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory medicine
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | DIC / 血管作動性物質 / サイトカイン |
Research Abstract |
We investigated the effect of erythropoietin, carbon monoxide release molecule and SnPP that may be able to interrupt interaction between coagulation and inflammation, on LPS-induced rat DIC model. The estimated markers were blood coagulation, fibrinolysis, organ injury, vasoactive substances, pathological findings and the mRNA expression of hemostatic substances. Although the effect of these drugs were different among doses or organs, such drugs without the influence on coagulation and fibrinolysis were expected as new DIC drugs.
|
Report
(4 results)
Research Products
(50 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article]2009
Author(s)
朝倉英策, 他
-
Journal Title
白血病治療マニュアル (分担 : DICに対する対策)(南江堂)
Pages: 157-160
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-