Establishment and evaluation of the measurement of serum Smad1 in diabetic vascular complications.
| Project/Area Number |
21590628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kagawa University (2011)
The University of Tokushima (2009-2010) |
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Principal Investigator |
KONDO Naoki 香川大学, 医学部附属病院, 病院助教 (80522789)
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| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Tatsuya 徳島大学, 大学院・ヘルスバイオサイエンス研究科, 助教 (80425446)
MATSUURA Motokazu 徳島大学, 大学院・ヘルスバイオサイエンス研究科, 助教 (10403734)
村上 太一 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (30403736)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 糖尿病 / 血管合併症 / Smad1 / バイオマーカー / BMP4 / MGP |
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| Research Abstract |
In order to clarify the functional role of Smad1 in vascular cells during the course of progression of diabetic vascular complications, potential of serum Smad1 as an early biomarker to detect the development and progression of atherosclerosis in type 2 diabetes was examined.(1) Existence of non-phosphorylated, C-terminus phosphorylated and linker-phosphorylated Smad1 was found. Profiles for the values of each Smad1 form in serum were made.(2) Serum MGP was found as a surrogate marker for evaluation of motions of Smad1-related molecules in STZ-induced diabetic mice models.(3) Negative association was observed between severity of atherosclerosis in abdominal aorta and serum MGP levels in patients. Significant difference of MGP-SNPs in the influence on the development of diabetic vascular complications was found, which are independent of the levels of serum MGP in these patients.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy2011
Author(s)
Tominaga T, Abe H, Ueda O, Goto C, Nakahara K, Murakami T, Mima A, Nagai K, Araoka T, Kishi S, Fukushima N, Jishage KI, Doi T
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Journal Title
J Biol Chem
Volume: 286(22)
Issue: 22
Pages: 20109-16
DOI
Related Report
Peer Reviewed
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[Presentation] BMP4/ Smad1 Signaling Is a Critical Therapeutic Target for Diabetic Nephropathy2010
Author(s)
Matsubara T, Abe H, Ueda O, Tominaga T, Mima A, Nagai K, Torikoshi K, Araki M, Goto C, Kinosaki M, Jishage K, Fukushima N, Iehara N, Fukatsu A, Arai H, Doi T
Organizer
43^<rd> American Society of Nephrology(ASN) Annual
Place of Presentation
Meeting, Denver
Year and Date
2010-11-19
Related Report
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