Analyzing the participation of Helicobacter pylori infection in acute coronary syndrome(ACS)
| Project/Area Number |
21590629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kochi University |
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Principal Investigator |
SUGIURA Teturo 高知大学, 教育研究部・医療学系, 教授 (50171145)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATA Jun 高知大学, 教育研究部・医療学系, 教授 (90206748)
KUMON Yoshitaka 高知大学, 教育研究部・医療学系, 准教授 (40215033)
TAKEUCHI Hiroaki 高知大学, 教育研究部・医療学系, 講師 (90346560)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | ヘリコバクター・ピロリ / 血小板凝集 / 菌体膜蛋白 / 急性冠症候群 / 特異抗体 / 血小板凝集・活性化 / 作製抗体(抗1pp20抗体) / 血小板活性化機序 / 作製抗体(抗lpp20抗体) |
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| Research Abstract |
We had previously found the certain components of H. pylori involved in development of H. pylori associated-ITP through the event which the bacterial component binds to platelet. In this study, we attempted to seek the bacterial component binds to platelet using western blotting with IP and LC-MS/ MS for analyzing the participation of Helicobacter pylori infection in ACS. Eventually, an outer membrane protein of H. pylori(HP-OMP) was identified among 11 candidate bacterial proteins followed by western blotting(IP) with all 11 His-fusion candidate proteins prepared. The platelet aggregation experiment demonstrated that the HP-OMP could definitely aggregate platelets via binding to surface of the platelet. Furthermore, the antibody specific to HP-OMP(anti-HP-OMP) was made with rabbit immunization.
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Report
(4 results)
Research Products
(103 results)
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[Journal Article] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy2011
Author(s)
Kubo T, Kitaoka H, Okawa M, Yamanaka, S, Hirota T, Baba Y, Hayato K, Yamasaki N, Matsumura Y, Yasuda N, Sugiura T, Doi YL
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Journal Title
Circulation Journal
Volume: 75
Pages: 919-926
NAID
Related Report
Peer Reviewed
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[Journal Article] Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophic cardiomyopathy2010
Author(s)
Kubo T, Kitaoka H, Okawa M, Yamanaka S, Hirota T, Hoshikawa E, Hayato K, Yamasaki N, Matsumura Y, Yasuda N, Sugiura T, Doi YL
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Journal Title
Clinical Cardiology
Volume: 33
Related Report
Peer Reviewed
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[Presentation] Superoxide dismutase (SOD) of Helicobacter pylori clinical isolates from patients with gastroduodenal diseases2011
Author(s)
Morishita K, Takeuchi H, Shimamura T, Morimoto N, Kadota Y, Tsuda M, Taniguchi T, Ukeda H, Sugiura T, Yamamoto T
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo convention center, Japan
Related Report
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[Presentation] Evaluation of Natural product, Refined Deep Seawater, for Helicobacter pylori colonization and intestinal flora condition, and its application2011
Author(s)
Takeuchi H, Kawada M, Tai H, Yamamoto E, Yasukawa T, Nakagawa K, Morimoto N, Ikegami Y, Sugiura T
Organizer
World Congress of Microbes-2011 : 1st Annual Symposium of Bacteriology and Infection
Place of Presentation
Beijing International Convention Center, China
Related Report
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[Presentation] 推算GFRの有用性2010
Author(s)
久原太助, 片岡浩巳, 山中茂雄, 小倉克巳, 杉浦哲朗
Organizer
第42回日本臨床検査自動化学会総会
Place of Presentation
神戸国際会議場(神戸)
Related Report
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