Establishment of biomarker panel for the early detection of atherosclerosis and the prevention of the cardio-renal syndromes in obesity and metabolic syndrome-role of the phenotypes and the function of peripheral blood monocytes-
Project/Area Number |
21590646
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
Principal Investigator |
SATOH Noriko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究室長(臨床代謝栄養) (80373512)
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Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Koji 独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 部長 (50283594)
KOTANI Kazuhiko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 客員室長 (60335510)
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Co-Investigator(Renkei-kenkyūsha) |
OGAWA Yoshihiro 東京医科歯科大学, 大学院・医歯学総合研究科・分子内分泌内科学分野, 教授 (70291424)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 内科 / 脂質 / 医療・福祉 / 遺伝子 / 動脈硬化 |
Research Abstract |
We have revealed that the phenotypes of monocyte(inflammatory M1 type and anti-inflammatory M2 type : qualitative changes) are significantly associated with the known cardiovascular risks and that unfavorable pro-inflammatory(M1)/anti-inflammatory(M2)-like phenotypes of peripheral blood monocytes are improved by the treatment with diabetic or anti-hyperlipidemic drugs in Japanese patients with obesity and metabolic syndrome from 1050 subjects in the database of National Hospital Organization. Accordingly, these data suggest the efficacy of the measurement of phenotypes of monocytes for early detection of atherosclerosis and the prevention of cardiovascular diseases in obesity and metabolic syndrome.
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Report
(4 results)
Research Products
(141 results)
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[Journal Article]2012
Author(s)
Satoh-Asahara N, Shimatsu A, Sasaki Y, Nakaoka H, Himeno A, Tochiya M, Kono S, Takaya T, Ono K, Wada H, Suganami T, Koji Hasegawa K, and Ogawa Y
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Journal Title
Diabetes Care
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients2012
Author(s)
Himeno A, Satoh-Asahara N, Usui T, Wada H, Tochiya M, Kono S, Yamada-Goto N, Katsuura G, Hasegawa K, Nakao K, Shimatsu A
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Journal Title
Metabolism
Volume: 61
Pages: 255-261
Related Report
Peer Reviewed
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[Journal Article] α1-Antitrypsin-low-density-lipoprotein Serves as a Marker of Smoking-specific Oxidative Stress2012
Author(s)
Wada H, Ura S, Satoh-Asahara N, Kitaoka S, Mashiba S, Akao M, A be M, Ono K, Morimoto T, Fujita M, Shimatsu A, Takahashi Y, Hasegawa K
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Journal Title
J Atheroscler Thromb
Volume: 19
Pages: 47-58
NAID
Related Report
Peer Reviewed
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[Journal Article] Distinct characteristics of circulating vascular endothelial growth factor-A and C levels in human subjects2011
Author(s)
Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K.
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Journal Title
Pros ONE
Volume: 6
Issue: 12
Pages: 29351-29351
DOI
Related Report
Peer Reviewed
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[Journal Article] The Japan Obesity Metabolic Syndrome Study(JOMS) Group. Serum Amyloid A Low-density Lipoprotein Levels and Smoking Status in Obese Japanese Patients2011
Author(s)
Kotani K, Satoh-Asahara N, Kato Y, Araki R, Himeno A, Yamakage H, Koyama K, Tanabe T, Oishi M, Okajima T, Shimatsu A
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Journal Title
J Int Med Res
Volume: 39
Pages: 1917-1922
Related Report
Peer Reviewed
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[Journal Article] Increased Expression of Macrophage-inducible C-type Lectin in Adipose Tissue of Obese Mice and Humans2011
Author(s)
Ichioka M, Suganami T, Tsuda N, Shirakawa I, H irata Y, Satoh-Asahara N, Shimoda Y, Tanaka M, Kim-Saijo M, Miyamoto Y, Kamei Y, Sata M, Ogawa Y
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Journal Title
Diabetes
Volume: 60
Pages: 15-19
Related Report
Peer Reviewed
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[Journal Article] The Japan Obesity Metabolic Syndrome Study(JOMS) Group. Urinary Cystatin C as a Potential Risk Marker for Cardiovascular Disease and Chronic Kidney Disease in Patients with Obesity and Metabolic Syndrome2011
Author(s)
Satoh-Asahara N, Suga mami T, Majima T, Kotani K, Kato Y, Araki R, Koyama K, Okajima T, Tanabe M, Oishi M, Himeno A, Kono S, Sugawara A, Masakazu H, Ogawa Y, and Shimatsu A
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Journal Title
Clin J Am Soc Nephrol
Volume: 6
Pages: 265-273
Related Report
Peer Reviewed
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[Journal Article] Remnantt-like particle cholesterol and serum amyloid A-low-density lipoprotein levels in obese subjects with metabolic syndrome2011
Author(s)
Kotani K, Satoh-Asahara N, Kato Y, Araki R, Himeno A, Yamakage H, Koyama K, Tanabe T, Oishi M, Okajima T, Shimatsu A, The Japan Obesity Metabolic Syndrome Study (JOMS) Group
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Journal Title
J Clin Lipidol
Volume: 5
Pages: 395-400
Related Report
Peer Reviewed
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[Journal Article] Serum Amyloid A Low-density Lipoprotein Levels and Smoking Status in Obese Japanese Patients2011
Author(s)
Kotani K, Satoh-Asahara N, Kato Y, Araki R, Himeno A, Yamakage H, Koyama K, Tanabe T, Oishi M, Okajima T, Shimatsu A, The Japan Obesity Metabolic Syndrome Study (JOMS) Group
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Journal Title
J Int Med Res
Volume: 39
Pages: 1917-1922
Related Report
Peer Reviewed
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[Journal Article] Urinary Cystatin C as a Potential Risk Marker for Cardiovascular Disease and Chronic Kidney Disease in Patients with Obesity and Metabolic Syndrome2011
Author(s)
Satoh-Asahara N, Sugamami T, Majima T, Kotani K, Kato Y, Araki R, Koyama K, Okajima T, Tanabe M, Oishi M, Himeno A, Kono S, Sugawara A, Masakazu H, Ogawa Y, Shimatsu A, The Japan Obesity Metabolic Syndrome Study (JOMS) Group
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Journal Title
Clin J Am Soc Nephrol
Volume: 6
Pages: 265-273
Related Report
Peer Reviewed
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[Journal Article] Increased Expression of Macrophage-inducible C-type Lectin in Adipose Tissue of Obese Mice and Humans.2011
Author(s)
Ichioka M, Suganami T, Tsuda N, Shirakawa I, Hirata Y, Satoh-Asahara N, Shimoda Y, Tanaka M, Kim-Saijo M, Miyamoto Y, Kamei Y, Sata M, Ogawa Y.
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Journal Title
Diabetes
Volume: 60
Pages: 819-826
Related Report
Peer Reviewed
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[Journal Article] Urinary Cystatin C as a Potential Risk Marker for Cardiovascular Disease and Chronic Kidney Disease in Patients with Obesity and Metabolic Syndrome.2011
Author(s)
Satoh-Asahara N, Sugamami T, Majima T, Kotani K, Kato Y, Araki R, Koyama K, Okajima T, Tanabe M, Oishi M, Himeno A, Kono S, Sugawara A, Masakazu H, Ogawa Y, Shimatsu A, The Japan Obesity Metabolic Syndrome Study (JOMS) Group.
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Journal Title
Clin J Am Soc Nephrol
Volume: 6
Pages: 265-273
Related Report
Peer Reviewed
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[Journal Article] LOX-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice2010
Author(s)
Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Horie T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
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Journal Title
Biochem Biophys Res Commun
Volume: 398
Pages: 576-580
Related Report
Peer Reviewed
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[Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance2010
Author(s)
Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano, T, Fujita M, Kita T, Shimatsu A, Hasegawa K
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Journal Title
Atherosclerosis
Volume: 208
Pages: 512-517
Related Report
Peer Reviewed
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[Journal Article] The influence of metabolic syndrome and chronic kidney disease on the hemorheology assessed by the microchannel method.2010
Author(s)
Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Horie T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K.
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Journal Title
Biochem Biophys Res Commun
Volume: 398
Pages: 576-580
Related Report
Peer Reviewed
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[Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance.2010
Author(s)
Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano, T, Fujita M, Kita T, Shimatsu A, Hasegawa K.
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Journal Title
Atherosclerosis 208
Pages: 512-517
Related Report
Peer Reviewed
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[Journal Article] A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome.2009
Author(s)
Kotani K, Satoh N, Kato Y, Araki R, Koyama K, Okajima T, Tanabe M, Oishi M, Yamakage H, Yamada K, Hattori M, Shimatsu A.
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Journal Title
Atherosclerosis 204
Pages: 526-531
Related Report
Peer Reviewed
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[Journal Article] Effects of risedronate or alfacalcidol on bone mineral density, bone turnover, back pain, and fractures in Japanese men with primary osteoporosis : results of a two-year strict observational study.2009
Author(s)
Majima T, Shimatsu A, Komatsu Y, Satoh N, Fukao A, Ninomiya K, Matsumura T, Nakao K.
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Journal Title
J Bone Miner Metab 27
Pages: 168-174
Related Report
Peer Reviewed
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[Journal Article] The Japan Obesity Metabolic Syndrome Study(JOMS) Group. Remnantt-like particle cholesterol and serum amyloid A-low-density lipoprotein levels in obese subjects with metabolic syndrome
Author(s)
Kotani K, Satoh-Asahara N, Kato Y, Araki R, Himeno A, Yamakage H, Koyama K, Tanabe T, Oishi M, Okajima T, Shimatsu A
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Journal Title
J Clin Lipidol
Volume: 5
Pages: 395-400
Related Report
Peer Reviewed
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[Presentation] Soluble LOX-1 and LOX Index in Sera of Smoking Patients are Closely Associated with Highly Sensitive CRP and Expired Air Carbon Monoxide Concentrations2011
Author(s)
Takanabe-Mori R, Ono K, Wada H, Takaya T, Yamakage H, Satoh-Asahara N, Shimatsu A, Takahashi Y, Fujita M, Fujita Y, Sawamura T, Hasegawa K
Organizer
American Heart Association Scientific Sessions 2011
Place of Presentation
Florida
Related Report
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[Presentation] Serum Soluble LOX-1 Levels are Increased in Close Association With hsCRP Levels and Expired Air CO Concentrations in Smokers2011
Author(s)
Takanabe-Mori R, Ono K, Wada H, Takaya T, Yamakage H, Satoh-Asahara N, Shimatsu A, Takahashi Y, Fujita M, Fujita Y, Sawamura T, Hasegawa K
Organizer
The 14th Annual INTERNATIONAL TORONTO HEART SUMMIT Together with the ISCHF A Member of the World Heart Federation
Place of Presentation
Toronto, Canada
Related Report
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[Presentation] Angiotensin receptor blocker(ARB)reduces urinary concentrations of neutrophil gelatinase-associated lipocalin(Ngal)in diabetes and obesity.2010
Author(s)
Kasahara M, Mori K, Kuwabara T, Satoh N, Yokoi H, Saito Y, mamaki H, Nagae T, Ogawa Y, Kawanishi T, Shimatsu A, Sugawara A, Mukoyama M, Nakao K.
Organizer
14th International Congress of Endocrinology(ICE2010)
Place of Presentation
京都
Year and Date
2010-03-28
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[Presentation] Placental Growth Factor is a Sensitive Indicator of a Weight Gain after Successful Smoking Cessation.2010
Author(s)
Hiromichi Wada, Noriko Satoh, Shuichi Ura, Akira Yamada, Masaharu Akao, Mitsura Abe, Junko Funatsu, Hisahi Ogawa, Maki Nishio, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa.
Organizer
The 74th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
京都
Year and Date
2010-03-07
Related Report
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[Presentation] Serum Levels of α1-Antitrypsin-LDL are Negatively Associated with Soluble VEGF Receptor-1 in Smokers and Decrease after Successful Smoking Cessation.2010
Author(s)
Hiromichi Wada, Noriko Satoh, Shuji Kitaoka, Shuichi Ura, Akira Yamada, Masaharu Akao, Mitsuru Abe, Hunko Funatsu, Hisashi Ogawa, Maki Nishio, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa.
Organizer
The 74th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
京都
Year and Date
2010-03-07
Related Report
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[Presentation] Soluble VEGF Receptor-2 is a Possible Novel Indicator of Impaired Angiogenesis in Metabolic Syndrome.2010
Author(s)
Hiromichi Wada, Noriko Satoh, Shuji Kitaoka, Ko Ono, Tatsuya Morimoto, Teruhisa Kawamura, Tameo Nakano, Masatoshi Fujita, Toru Kita, Akira Shimatsu, Koji Hasegawa.
Organizer
The 74th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
京都
Year and Date
2010-03-07
Related Report
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[Presentation] Vascular Endothelial Growth Factor-C is Increased in Patients with Met S in Close Association with Blood Pressure.2010
Author(s)
Hiromichi Wada, Noriko Satoh, Shuji Kitaoka, Shuichi Ura, Akira Yamada, Masaharu Akao, Mitsuru Abe, Junko Funatsu, Hisahi Ogawa, Maki Nishio, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa.
Organizer
The 74th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
京都
Year and Date
2010-03-06
Related Report
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[Presentation] Salivary Cortisol Is Related to Coronary Heart Disease Risk.2010
Author(s)
Hiromichi Wada, Koji Hasegawa, Takeshi Usui, Sachiko Terashima, Noriko Satoh, Akihiro Himeno, Yuko Iida, Akira Yamada, Shuichi Ura, Shuji Kitaoka, Masaharu Akao, Mitsuru Abe, Masatoshi Fujita, Akira Shimatsu, Yuko Takahashi.
Organizer
The 74th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
京都
Year and Date
2010-03-06
Related Report
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