Development of a new endoscopic therapy using RNAi for intestinal fibrosis of Crohn's disease
| Project/Area Number |
21590807
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
SUZUKI Kenji 新潟大学, 医歯学総合病院, 講師 (00303123)
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| Co-Investigator(Kenkyū-buntansha) |
松田 康伸 新潟大学, 医歯学系, 准教授 (40334669)
山際 訓 新潟大学, 医歯学系, 助教 (10419327)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 炎症性腸疾患 / クローン病 / 線維化 / siRNA / RNAi / 内視鏡 / 糖鎖 / 消化管狭窄 / RNA干渉 / 内視鏡的治療 |
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| Research Abstract |
We have developed a new siRNA medicine, STNM-01 with Stelic Institute. In this project, we studied the therapeutic effects and the mechanism of endoscopic submucosal injection of the STNM-01 for the treatment of intestinal fibrosis using animal models. We have successfully developed a novel endoscopic injection therapy of STNM-01 for the treatment of intestinal fibrosis of Crohn's disease. Using this technique, we have started a phase I clinical trial for patients with Crohn's disease in Japan since January, 2012.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocyte in kidneys.2011
Author(s)
Saito A, Miyauchi N, Hashimoto T, Karasawa T, Han GD, Kayaba M, Sumi T, Tomita M, Ikezumi Y, Suzuki K, Koitabashi Y, Shimizu F, Kawachi H
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Journal Title
Am J Physiol Regul Integr Comp Physiol
Volume: 300
Pages: 340-348
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[Journal Article] The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling2011
Author(s)
Nagata M, Nuckolls GH, Wang X. Shum L, Seki Y, Kawase T, Takahashi K, Nonaka K, Takahashi I, Noman AA, Suzuki K, Slavkin HC
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Journal Title
Bone
Volume: 48
Pages: 847-856
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[Journal Article] Telmisaratan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy2010
Author(s)
Sukumaran V, Watanabe K, Veeraveedu PT, Thandavarayan RA, Gurusamy N, Ma M, Yagamaguchi K, Suzuki K, Kodama M, Aizawa Y
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Journal Title
Hypertension Res
Volume: 33
Pages: 695-702
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