Loss of HB-EGF accelerates carbon tetrachloride induced liver injury in mice

• Project/Area Number: 21590844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: KISO Shinichi 大阪大学, 医学系・研究科, 助教 (40335352)
• Co-Investigator(Kenkyū-buntansha): YOSHIA Yuichi 大阪大学, 医学系・研究科, 助教 (30457014) ; WATABE Kenji 大阪大学, 医学系・研究科, 助教 (50379244) ; TSUTSUI Shusaku 大阪大学, 医学系・研究科, 助教 (10359846)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: HB-EGF / 肝再生 / 肝線維化 / ヘパリン結合性 / ノックアウトマウス / HGF

Research Abstract

Heparin-binding EGF-like growth factor(HB-EGF) is a member of EGF family of growth factors that binds to and stimulates EGF receptors(EGFR) and EerbB4. Previously, we demonstrated that the HB-EGF was induced in response to several liver injuries and also showed that transgenic expression of HB-EGF in mice accelerated proliferation of hepaocyte during liver regeneration after partial hepatectomy. However, the role of HB-EGF in acute liver injury induced by hepatotoxin remains still unclear. To clarify this issue, we generated liver specific HB-EGF knockout(KO) mice. At 24 hours after CCl4 injection, KO mice showed significant increased ALT level compared with WT mice(5486+ 1961 IU/ l vs. 2275+ 656 IU/ l, p<0. 05), indicating that hepatic HB-EGF deficiency caused acceleration of liver injury. Western blotting also showed significant reduced expression level of PCNA protein at 48 hours after CCl4injection. Consistent with this, the number of BrdU positive hepatocytes in KO mice was lower than that in WT mice at 48 and 72 hours after CCl4 injection. This impaired liver regeneration in KO mice was associated with reduced activity of ERK1/ 2 MAP kinase in injured livers. Furthermore, HB-EGF significantly suppressed apoptosis of mouse hepaocyte cell lines induced by TNFαin a dose dependent manner, indicating the possible anti-apoptotic role of HB-EGF. Conclusion : Our current study demonstrated that HB-EGF might play a protective role during acute liver injury through ERK1/ 2 activation.

Research Products

• [Journal Article] Glycobiology. N-Acetylglucosaminyltransferase V regulates TGF-βresponse in hepatic stellate cells and the progression of steatohepatitis (2012)
  • Author(s): Kamada Y, Mori K, Matsumoto H, Kiso S, Yoshida Y, Shinzaki S, Hiramatsu N, Ishii M, Moriwaki K, Kawada N, Takehara T, Miyoshi E
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection (2012)
  • Author(s): Kurokawa M, Hiramatsu N, Oze T, Yakushijin T, Miyazaki M, Hosui A, Miyagi T, Yoshida Y, Ishida H, Tatsumi T, Kiso S, Kanto T, Kasahara A, Iio S, Doi Y, Yamada A, Oshita M, Kaneko A, Mochizuki K, Hagiwara H, Mita E, Ito T, Inui Y, Katayama K, Yoshihara H,
  • Journal Title: J Gastroenterol Volume: (In press)
  • NAID: 10030650709
  • Peer Reviewed
• [Journal Article] Protective role of adiponectin against ethanol-induced gastric injury in mice (2012)
  • Author(s): Shunsuke Yamamoto, Kenji Watabe, Hiroshi Araki, Yoshihiro Kamada, Motohiko Kato, Takashi Kizu, Shinichi Kiso, Shusaku Tsutsui, Masahiko Tsujii, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Norio Hayashi, and Tetsuo Takehara
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: (In press)
  • NAID: 40019386509
  • Peer Reviewed
• [Journal Article] Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin (2012)
  • Author(s): Oze T, Hiramatsu N, Song C, Yakushijin T, Iio S, Doi Y, Oshita M, Hagiwara H, Mita E, Ito T, Inui Y, Hijioka T, Tamura S, Yoshihara H, Inoue A, Imai Y, Hayashi E, Kato M, Miyazaki M, Hosui A, Miyagi T, Yoshida Y, Tatsumi T, Kiso S, Kanto T, Kasahara A, Hayashi N, Takehara T
  • Journal Title: J Gastroenterol Volume: 47(3) Pages: 334-42
  • NAID: 10030560255
  • Peer Reviewed
• [Journal Article] Indications and limitations for aged patients with chronic hepatitis C in pegylated interferon alfa-2b plus ribavirin combination therapy (2011)
  • Author(s): Oze T, Hiramatsu N, Yakushijin T, Mochizuki K, Oshita M, Hagiwara H, Mita E, Ito T, Fukui H, Inui Y, Hijioka T, Inada M, Kaytayama K, Tamura S, Yoshihara H, Inoue A, Imai Y, Kato M, Miyagi T, Yoshida Y, Tatsumi T, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N
  • Journal Title: J Hepatol Volume: 54(4) Pages: 604-11
  • Peer Reviewed
• [Journal Article] Efficacy of re-treatment with pegylated interferon plus ribavirin combination therapy for patients with chronic hepatitis C in Japan (2011)
  • Author(s): Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yoshiaki Inui, Hiroyuki Fukui, Taizo Hijioka, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Atsushi Hosui, Takuya Miyagi, Hisashi Ishida, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara and Norio Hayashi
  • Journal Title: Gastroenterol Volume: 46(8) Pages: 1031-7
  • NAID: 10029563329
  • Peer Reviewed
• [Journal Article] The efficacy of extended treatment with pegylated interferon plus ribavirin in patients with HCV genotype 1 and slow virologic response in Japan (2011)
  • Author(s): Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Kazuho Imanaka, Akira Yamada, Masahide Oshita, Akira Kaneko, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Toshihiko Nagase, Yoshiaki Inui, Taizo Hijioka, Shinji Tamura, Harumasa , Eijiro Hayashi, Yasuharu Imai, Michio Kato, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida, Hisashi Ishida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, and Norio Hayashi
  • Journal Title: J Gastroenterol Volume: 46(7) Pages: 944-52
  • NAID: 10029313419
  • Peer Reviewed
• [Journal Article] Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis (2011)
  • Author(s): Yamamoto S, Watabe K, Tsutsui S, Kiso S, Hamasaki T, Kato M, Kamada Y, Yoshida Y, Kihara S, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Hayashi N, Matsuzawa Y
  • Journal Title: Dig Dis Sci Volume: 56(8) Pages: 2354-60
  • Peer Reviewed
• [Journal Article] Association of low serum adiponectin levels with erosive esophagitis in men ; an analysis of 2405 subjects undergoing physical check-ups (2011)
  • Author(s): Motohiko Kato, Kenji Watabe, Toshimitsu Hamasaki, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Shunsuke Yamamoto, Yoshihiro Kamada, Yuichi Yoshida, Shinichi Kiso, Shusaku Tsutsui, Shinji Kihara, Norio Hayashi, and Yuji Matsuzawa
  • Journal Title: J Gastroenterology Volume: 46(12) Pages: 1361-7
  • NAID: 10030295134
  • Peer Reviewed
• [Journal Article] Estrogen deficiency worsens steatohepatitis in mice fed high fat and high cholesterol diet (2011)
  • Author(s): Kamada Y, Kiso S, Yoshida Y, Chatani N, Kizu T, Hamano M, Tsubakio M, Takemura T, Ezaki H, Hayashi N, Takehara T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 301(6)
  • Peer Reviewed
• [Journal Article] Efficacy of pegylated interferon plus ribavirin combination therapy for hepatitis C patients with normal ALT levels : a matched case-control study (2011)
  • Author(s): Hiramatsu N, Inoue Y, Oze T, Kurashige N, Yakushijin T, Mochizuki K, Miyagi T, Tatsumi T, Kiso S, Kanto T, Kasahara A, Takehara T, Oshita M, Mita E, Hagiwara H, Inui Y, Katayama K, Tamura S, Yoshihara H, Imai Y, Hayashi N
  • Journal Title: J Gastroenterol Volume: 46(11) Pages: 1335-43
  • NAID: 10030295018
  • Peer Reviewed
• [Journal Article] Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin (2011)
  • Author(s): Inoue Y, Hiramatsu N, Oze T, Yakushijin T, Mochizuki K, Fukuda K, Mita E, Haruna Y, Inoue A, Imai Y, Hosui A, Miyagi T, Yoshida Y, Tatsumi T, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N
  • Journal Title: J Med Virol Volume: 83(3) Pages: 419-27
  • Peer Reviewed
• [Journal Article] Amino acid substitution_in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin. (2011)
  • Author(s): Inoue Y, Kiso S, (15番目), 他17名
  • Journal Title: J Med Virol. Volume: 83(3) Pages: 419-27
  • Peer Reviewed
• [Journal Article] Factors affecting efficacy in patients with genotype 2 chronic hepatitis C treated by pegylated interferon alpha-2b and ribavirin : reducing drug doses has no impact on rapid and sustained virological responses (2010)
  • Author(s): Inoue Y, Hiramatsu N, Oze T, Yakushijin T, Mochizuki K, Hagiwara H, Oshita M, Mita E, Fukui H, Inada M, Tamura S, Yoshihara H, Hayashi E, Inoue A, Imai Y, Kato M, Miyagi T, Hohsui A, Ishida H, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N
  • Journal Title: J Viral Hepat Volume: 17(5) Pages: 336-44
  • Peer Reviewed
• [Journal Article] Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice (2010)
  • Author(s): Yamada T, Araki H, Watabe K, Kamada Y, Kiso S, Ogiyama H, Nishihara T, Kihara S, Funahashi T, Shimomura I, Tsutsui S, Hayashi N
  • Journal Title: J Gastroenterol Volume: 45(7) Pages: 742-9
  • NAID: 10026707095
  • Peer Reviewed
• [Journal Article] Lack of adiponectin promotes formation of cholesterol gallstones in mice (2010)
  • Author(s): Ogiyama H, Kamada Y, Kiso S, Araki H, Yamada T, Nishihara T, Watabe K, Tochino Y, Kihara S, Funahashi T, Kanno K, Shimomura I, Tsutsui S, Tazuma S, Hayashi N
  • Journal Title: Biochem Biophys Res Commun Volume: 399(3) Pages: 352-8
  • NAID: 10030560839
  • Peer Reviewed
• [Journal Article] Reduced risk of hepatocellular carcinoma after interferon therapy in aged patients with chronic hepatitis C is limited to sustained virological responders (2010)
  • Author(s): Imai Y, Tamura S, Tanaka H, Hiramatsu N, Kiso S, Doi Y, Inada M, Nagase T, Kitada T, Imanaka K, Fukuda K, Takehara T, Kasahara A, Hayashi N
  • Journal Title: J Viral Hepat Volume: 17(3) Pages: 185-91
  • Peer Reviewed
• [Journal Article] Factors affecting efficacy in patients with genotype 2 chronic hepatitis C treated by pegylated interferon alpha-2b and ribavirin : reducing drug doses has no impact on rapid and sustained virological responses. (2010)
  • Author(s): Inoue Y, Kiso S, (20番目), 他22名
  • Journal Title: J Viral Hepat. Volume: 17(5) Pages: 336-44
  • Peer Reviewed
• [Journal Article] Reduced risk of hepatocellular carcinoma after interferon therapy in aged patients with chronic hepatitis C is limited to sustained virological responders. (2010)
  • Author(s): Imai Y., Kiso S, (5番目), 他12名
  • Journal Title: J Viral Hepat. Volume: 17(3) Pages: 185-91
  • Peer Reviewed
• [Journal Article] Indications and limitations for aged patients with chronic hepatitis C in pegylated interferon alfa-2b plus ribavirin combination therapy. (2010)
  • Author(s): Oze T, Kiso S, (17番目), 他19名
  • Journal Title: J Hepatol. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Lack of adiponectin promotes formation of cholesterol gallstones in mice. (2010)
  • Author(s): Ogiyama H, Kiso S, (3番目), 他13名
  • Journal Title: Biochem Biophys Res Commun. Volume: 399(3) Pages: 352-358
  • NAID: 10030560839
  • Peer Reviewed
• [Journal Article] Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice. (2010)
  • Author(s): Yamada T, Kiso S, (5番目), 他10名
  • Journal Title: J Gastroenterol. Volume: 45(7) Pages: 742-9
  • NAID: 10026707095
  • Peer Reviewed
• [Journal Article] Reduced risk of hepatocellular carcinoma after interferon therapy in aged patients with chronic hepatitis C is limited to sustained virological resners (2010)
  • Author(s): Y Imai, S Kiso (5番目), 他12名
  • Journal Title: J Viral Hepat. 17 Pages: 185-191
  • Peer Reviewed
• [Journal Article] Factors affecting efficacy in patients with genotype 2 chronic hepatitis C treated by pegylated interferon alpha-2b and ribavirin : reducing drug doses has no impact on rapid and sustained virological responses (2010)
  • Author(s): Inoue Y, Kiso S (20番目), 他21名
  • Journal Title: J Viral Hepat 17 Pages: 336-344
  • Peer Reviewed
• [Journal Article] Werner syndrome as a possible cause of non-alcoholic steatohepatitis (2009)
  • Author(s): Hashizume H, Sato K, Takagi H, Kanda D, Kashihara T, Kiso S, Mori M
  • Journal Title: J Clin Pathol Volume: 62(11) Pages: 1043-5
  • Peer Reviewed
• [Journal Article] Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice (2009)
  • Author(s): Ezaki H, Yoshida Y, Saji Y, Takemura T, Fukushima J, Matsumoto H, Kamada Y, Wada A, Igura T, Kihara S, Funahashi T, Shimomura I, Tamura S, Kiso S, Hayashi N
  • Journal Title: Biochem Biophys Res Commun Volume: 378(1) Pages: 68-72
  • Peer Reviewed
• [Journal Article] Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice (2009)
  • Author(s): Kamada Y, Yoshida Y, Saji Y, Fukushima J, Tamura S, Kiso S, Hayashi N
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 296(2)
  • Peer Reviewed
• [Journal Article] Effect of interferon alpha-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with chronic hepatitis (2009)
  • Author(s): Kurokawa M, Hiramatsu N, Oze T, Mochizuki K, Yakushijin T, Kurashige N, Inoue Y, Igura T, Imanaka K, Yamada A, Oshita M, Hagiwara H, Mita E, Ito T, Inui Y, Hijioka T, Yoshihara H, Inoue A, Imai Y, Kato M, Kiso S, Kanto T, Takehara T, Kasahara A, Hayashi N
  • Journal Title: Hepatol Res. Volume: 39(5) Pages: 432-8
  • Peer Reviewed
• [Journal Article] Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B (2009)
  • Author(s): Kurashige N, Hiramatsu N, Ohkawa K, Yakushijin T, Kiso S, Kanto T, Takehara T, Kasahara A, Doi Y, Yamada A, Oshita M, Mita E, Hagiwara H, Nagase T, Yoshihara H, Hayashi E, Imai Y, Kato M, Kashihara T, Hayashi N
  • Journal Title: J Gastroenterol Volume: 44(6) Pages: 601-7
  • NAID: 10025175691
  • Peer Reviewed
• [Journal Article] Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction : An epidemiologic study of 3827 Japanese subjects (2009)
  • Author(s): Kamada Y, Nakamura T, Funahashi T, Ryo M, Nishizawa H, Okauchi Y, Fukushima J, Yoshida Y, Kiso S, Shimomura I, Hayashi N
  • Journal Title: J Clin Gastroenterol Volume: 43(10) Pages: 995-1000
  • Peer Reviewed
• [Journal Article] A novel therapeutic strategy with anti-CD9 antibody in gastric cancers (2009)
  • Author(s): Nakamoto T, Murayama Y, Oritani K, Boucheix C, Rubinstein E, Nishida M, Katsube F, Watabe K, Kiso S, Tsutsui S, Tamura S, Shinomura Y, Hayashi N
  • Journal Title: J Gastroenterol Volume: 44(9) Pages: 889-96
  • NAID: 10025581138
  • Peer Reviewed
• [Journal Article] Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance (2009)
  • Author(s): Kurashige N, Ohkawa K, Hiramatsu N, Yakushijin T, Mochizuki K, Oze T, Kiso S, Kanto T, Takehara T, Kasahara A, Doi Y, Yamada A, Fukuda K, Oshita M, Mita E, Fukui H, Nagase T, Yoshihara H, Imai Y, Kato M, Kashihara T, Hayashi N
  • Journal Title: J Gastroenterol Volume: 44(8) Pages: 864-70
  • NAID: 10025176735
  • Peer Reviewed
• [Journal Article] Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization (2009)
  • Author(s): Fukushima J, Kamada Y, Matsumoto H, Yoshida Y, Ezaki H, Takemura T, Saji Y, Igura T, Tsutsui S, Kihara S, Funahashi T, Shimomura I, Tamura S, Kiso S, Hayashi N
  • Journal Title: Hepatol Res Volume: 39(7) Pages: 724-38
  • NAID: 10025326832
  • Peer Reviewed
• [Journal Article] Pegylated interferon alpha-2b(Peg-IFN alpha-2b) affects early virologic response dose-dependently in patients with chronic hepatitis C genotype 1 during treatment with Peg-IFN alpha-2b plus ribavirin (2009)
  • Author(s): Oze T, Hiramatsu N, Yakushijin T, Kurokawa M, Igura T, Mochizuki K, Imanaka K, Yamada A, Oshita M, Hagiwara H, Mita E, Ito T, Inui Y, Hijioka T, Tamura S, Yoshihara H, Hayashi E, Inoue A, Imai Y, Kato M, Yoshida Y, Tatsumi T, Ohkawa K, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N
  • Journal Title: J Viral Hepat Volume: 16(8) Pages: 578-85
  • Peer Reviewed
• [Journal Article] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin (2009)
  • Author(s): Hiramatsu N, Oze T, Yakushijin T, Inoue Y, Igura T, Mochizuki K, Imanaka K, Kaneko A, Oshita M, Hagiwara H, Mita E, Nagase T, Ito T, Inui Y, Hijioka T, Katayama K, Tamura S, Yoshihara H, Imai Y, Kato M, Yoshida Y, Tatsumi T, Ohkawa K, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N
  • Journal Title: J Viral Hepat Volume: 16(8) Pages: 586-94
  • Peer Reviewed
• [Journal Article] Werner syndrome as a possible cause of non-alcoholic steatohepatitis (2009)
  • Author(s): H Hashizume, S Kiso (6番目), 他5名
  • Journal Title: J Clin Pathol 62 Pages: 1043-1045
  • Peer Reviewed
• [Journal Article] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin (2009)
  • Author(s): Hiramatsu N, Yoshida Y (22番目), Kiso S (25番目), 他25名
  • Journal Title: J Viral Hepat. 16(8) Pages: 586-94
  • Peer Reviewed
• [Journal Article] Pegylated interferon alpha-2b (Peg-IFN alpha-2b) affects early virologic response dose-dependently in patients with chronic hepatitis C genotype 1 during treatment with Peg-IFN alpha-2b plus ribavirin (2009)
  • Author(s): Oze T, Yoshida Y (20番目), Kiso S (23番目), 他25名
  • Journal Title: J Viral Hepat 16(8) Pages: 578-85
  • Peer Reviewed
• [Journal Article] Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization (2009)
  • Author(s): Fukushima J, Yoshida Y (4番目), Kiso S (14番目), 他12名
  • Journal Title: Hepatol Res. 39(7) Pages: 724-38
  • NAID: 10025326832
  • Peer Reviewed
• [Journal Article] Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance (2009)
  • Author(s): Kurashige N, Kiso S (7番目), 他20名
  • Journal Title: J Gastroenterol. 44(8) Pages: 864-70
  • NAID: 10025176735
  • Peer Reviewed
• [Journal Article] 免疫抑制・化学療法により発症するB型肝炎対策―厚生労働省「難治性肝・胆道疾患に関する調査研究」班 劇症肝炎分科会および「肝硬変を含めたウイルス性肝疾患の治療の標準化に関する研究」班合同報告― (2009)
  • Author(s): 坪内博仁, 木曽真一 (27番目), 他27名
  • Journal Title: 肝臓 50(1) Pages: 38-42
  • Peer Reviewed
• [Journal Article] A novel therapeutic strategy with anti-CD9 antibody in gastric cancers (2009)
  • Author(s): Nakamoto T, Kiso S (9番目), 他11名
  • Journal Title: J Gastroenterol. 44(9) Pages: 889-96
  • NAID: 10025581138
  • Peer Reviewed
• [Journal Article] アルコール問題への取り組み-内科 (消化器内科医) の立場から- (2009)
  • Author(s): 木曽真一
  • Journal Title: 大阪府内科医会会誌 18(1) Pages: 49-55
  • NAID: 40016715533
• [Journal Article] Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction : An epidemiologic study of 3827 Japanese subjects (2009)
  • Author(s): Kamada Y, Yoshida Y (8番目), Kiso S, (9番目), 他8名
  • Journal Title: J Clin Gastroenterol 43(10) Pages: 995-1000
  • Peer Reviewed
• [Journal Article] Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B (2009)
  • Author(s): Kurashige N Kiso S (5番目), 他18名
  • Journal Title: J Gastroenterol. 44(6) Pages: 601-7
  • NAID: 10025175691
  • Peer Reviewed
• [Journal Article] Effect of interferon alpha-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with chronic hepatitis (2009)
  • Author(s): Kurokawa M, Kiso S (21番目), 他20名
  • Journal Title: Hepatol Res 39(5) Pages: 432-8
  • Peer Reviewed
• [Journal Article] Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice (2009)
  • Author(s): Kamada Y, Yoshida Y (2番目), Kiso S (6番目), 他4名
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 296(2)
  • Peer Reviewed
• [Presentation] Protective role of heparin-binding EGF-like growth factor during liver fibrosis in mice (2011)
  • Author(s): Takemura T, Yoshida Y, Kizu T, Furuta K, Kamada Y, Hamano M, Tsubakio M, Chatani N, Ezakki H, Kiso S, Takehara T
  • Organizer: 2011年米国肝臓病学会(AASLD)
  • Place of Presentation: サンフランシスコ、米国
  • Year and Date: 2011-11-06
• [Presentation] GAB1 scaffolding adaptor protein protects from liver fibrosis during chronic liver injury in mice (2011)
  • Author(s): Kizu T, Yoshida Y, Takemura T, Furuta K, Kamada Y, Chatani N, Hamano M, Tsubakio M, Ezaki H, Kiso S, Takehara T
  • Organizer: 2011年米国肝臓病学会(AASLD)
  • Place of Presentation: サンフランシスコ、米国
  • Year and Date: 2011-11-06
• [Presentation] 肝再生・肝線維化進展過程におけるGab1の意義と肝幹/前駆細胞の関与 (2011)
  • Author(s): 吉田雄一、木曽真一、木津崇、竹原徹郎
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] 肝細胞癌におけるGab1の関与と肝細胞癌治療の新規分子標的としての可能性 (2011)
  • Author(s): 吉田雄一、木曽真一、椿尾真弓、木津崇、茶谷徳啓、古田訓丸、濱野美奈、竹村貴代、江崎久男、鎌田佳宏、竹原徹郎
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] 一般演題「肝細胞癌におけるGab1の関与と肝細胞癌治療の新規分子標的としての可能性」 (2011)
  • Author(s): 吉田雄一、木曽真一、椿尾真弓、木津崇、茶谷徳啓、古田訓丸、濱野美奈、竹村貴代, 江崎久男、鎌田佳宏、竹原徹郎
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] Takehara T Protective role of heparin-binding EGF-like growth factor during liver fibrosis in mice (2011)
  • Author(s): Takemura T, Yoshida Y, Kizu T, Furuta K, Kamada Y, Hamano M, Tsubakio M, Chatani N, Ezakki H, Kiso S
  • Organizer: 2011年米国肝臓病学会(AASLD)
  • Place of Presentation: サンフランシスコ、米国
• [Presentation] Takehara T GAB1 scaffolding adaptor protein protects from liver fibrosis during chronic liver injury in mice (2011)
  • Author(s): Kizu T, Yoshida Y, Takemura T, Furuta K, Kamada Y, Chatani N, Hamano M, Tsubakio M, Ezaki H, Kiso S
  • Organizer: 2011年米国肝臓病学会(AASLD)
  • Place of Presentation: サンフランシスコ、米国
• [Presentation] Norio HayashiGaB1 scaffolding adaptor protein is required for stem/ progenitor cell mediated liver Regeneration in mice (2010)
  • Author(s): Yuichi Yoshida, Takashi Kizu, Mayumi Tsubakio, Norihiro Chatani, Mina HamanoTakayo Takemura, Hisao Ezaki, Yoshihiro Kamada, Shinichi Kiso
  • Organizer: AASLD(ボストン)
  • Place of Presentation: ボストン、米国
• [Presentation] Suppressive effect of pegylated interferon alfa-2B plus ribavirin combination therapy on incidence of hepatocellular carcinoma in patients with chronic hepatitis C (2010)
  • Author(s): Tugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Michio Kato, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi
  • Organizer: AASLD(ボストン)
  • Place of Presentation: ボストン、米国
• [Presentation] HB-EGF conditional loss of liver accelerates the carbon tetrachloride induced liver injury in mice (2010)
  • Author(s): Takayo Takemura, Yuichi Yoshida, Yukiko Saji, Hisao Ezaki, Mina Hamano, Takashi Kizu, Mayumi Tsubakio, Norihiro Chatani, Yoshihiro Kamada, Shinichi Kiso, Norio Hayashi
  • Organizer: AASLD(ボストン)
  • Place of Presentation: ボストン、米国
• [Presentation] Norio Hayashi Estrogen deficiency enhanced the progression of steatohepatitis with increased macrophage infiltration in mice fed with high fat and high cholesterol diet (2010)
  • Author(s): Yoshihiro Kamada, Shinichi Kiso, Yuichi Yoshida, Hisao Ezaki, Takayo Takemura, Mina Hamano, Norihiro Chatani, Takashi Kizu, Mayumi Tsubakio
  • Organizer: AASLD(ボストン)
  • Place of Presentation: ボストン、米国
• [Presentation] Norio Hayashi Non-invasive evaluation of liver fibrosis by using virtual touch tissue quantification in patients with chronic hepatitis C (2010)
  • Author(s): Changho Song, Naoki Hiramatsu, Yuko Inoue, Mika Kurokawa, Tsugiko Oze, Takayuki Yakushijin, Kiyoshi Mochizuki, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Tetsuo Takehara
  • Organizer: AASLD(ボストン)
  • Place of Presentation: ボストン、米国
• [Presentation] アダプター蛋白Gab1は、肝再生過程における肝幹/前駆細胞の関与 (2010)
  • Author(s): 吉田雄一、木曽真一、林紀夫
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 横浜
• [Presentation] エストロゲン欠乏状態(閉経後)における高コレステロール血症のNASH病態進展への関与 (2010)
  • Author(s): 鎌田佳宏、木曽真一、林紀夫
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 横浜
• [Presentation] Peg-IFN/ Ribavirin非著効例に対する再治療について-多施設(OLF)共同研究- (2010)
  • Author(s): 小瀬嗣子、平松直樹、薬師神崇行、望月圭、萩原秀紀、三田英治、田村信司、吉原治正、今井康陽、林英二朗、吉田雄一、巽智秀、木曽真一、考藤達哉、笠原彰紀、竹原徹郎、林紀夫
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 横浜
• [Presentation] Peg-IFN/ Ribavirin併用療法の肝発癌制御効果について-多施設(OLF)共同研究- (2010)
  • Author(s): 小瀬嗣子、平松直樹、薬師神崇行、望月圭、尾下正秀、三田英治、吉原治正、今井康陽、木曽真一、考藤達哉、笠原彰紀、竹原徹郎、林紀夫
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 横浜
• [Presentation] Gab1 scaffolding adaptor protein is required for stem/progenitor cell mediated liver regeneration in mice. (2010)
  • Author(s): Yoshida Y, Kiso S, (9番目), 他8名
  • Organizer: AASLD (米国肝臓病学会)
  • Place of Presentation: Boston, USA
• [Presentation] Suppressive effect of pegylated interferon alfa-2B plus ribavirin combination therapy on incidence of hepatocellular carcinoma in patients with chronic hepatitis C. (2010)
  • Author(s): Tsugiko Oze, Shinichi Kiso, (21番目), 他23名
  • Organizer: AASLD (米国肝臓病学会)
  • Place of Presentation: Boston, USA
• [Presentation] HB-EGF conditional loss of liver accelerates the carbon tetrachloride induced liver injury in mice. (2010)
  • Author(s): Takako Takemura, Shinichi Kiso, (10番目), 他9名
  • Organizer: AASLD (米国肝臓病学会)
  • Place of Presentation: Boston, USA
• [Presentation] Non-invasive evaluation of liver fibrosis by using virtual touch tissue quantification in patients with chronic hepatitis C. (2010)
  • Author(s): Changho Song, Shinichi Kiso, (10番目), 他12名
  • Organizer: AASLD (米国肝臓病学会)
  • Place of Presentation: Boston, USA
• [Presentation] Estrogen defficiency enhanced the progression of steatohepatitis with increased macrophage infiltration in cholesterol diet. (2010)
  • Author(s): Yoshihiro Kamada, Shinichi Kiso, (2番目), 他8名
  • Organizer: AASLD (米国肝臓病学会)
  • Place of Presentation: Boston, USA
• [Presentation] 肝再生における肝幹/前駆細胞の関与:アダプター蛋白Gab1の重要性について:移植・再生医療ワークショップ2肝再生医学 (2010)
  • Author(s): 吉田雄一、木曽真一、林紀夫
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形県山形市
• [Presentation] 糖転移酵素N-アセチルグルコサミン転移酵素V(GnT-V)は肝線維化を抑制する (2010)
  • Author(s): 森華奈子、木曽真一, (8番目), 他8名
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形県山形市
• [Presentation] 慢性肝疾患におけるARFIを用いた肝線維化の非侵襲的評価 (2010)
  • Author(s): 宋昌浩、木曽真一, (9番目), 他10名
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形県山形市
• [Presentation] B型慢性肝疾患に対するラミブジン投与症例における肝発癌についての検討 (2010)
  • Author(s): 黒川三佳、木曽真一, (18番目), 他19名
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形県山形市
• [Presentation] 難治性C型肝炎に対するpeg-IFN/Ribavirin併用療法におけるHCV Core領域アミノ酸変異が治療後再燃におよぼす影響について (2010)
  • Author(s): 井上裕子、木曽真一, (14番目), 他16名
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形県山形市
• [Presentation] Real time PCR法を用いたHCV-RNA測定系におけるC型肝炎に対するpeg-IFN/RBV併用療法の治療効果予測 (2010)
  • Author(s): 小瀬嗣子、木曽真一, (21番目), 他23名
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形県山形市
• [Presentation] Peg-IFN/Ribavirin併用療法の肝発癌抑制効果について-多施設(OLF)共同研究- (2010)
  • Author(s): 小瀬嗣子、木曽真一, (11番目), 他13名
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形県山形市
• [Presentation] HB・EGF(heparin binding EGF-like growth factor)欠損はマウス急性肝障害を増悪させる (2010)
  • Author(s): 吉田雄一、木曽真一, (7番目), 他6名
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形県山形市
• [Presentation] エストロゲン欠乏状態(閉経後)における高コレステロール血症のNASH病態進展への関与 (2010)
  • Author(s): 鎌田佳宏、木曽真一、林紀夫
  • Organizer: 第52回日本消化器病学会大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] アダプター蛋白Gab1は、肝再生過程における肝幹/前駆細胞の増殖分化に関与する:ワークショップ16:肝胆膵疾患と組織幹細胞/progenitor cell:病態解析と治療戦略 (2010)
  • Author(s): 吉田雄一、木曽真一、林紀夫
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] Peg-IFN/Ribavirin併用療法の肝発癌抑制効果について-多施設(OLF)共同研究- (2010)
  • Author(s): 小瀬嗣子、木曽真一, (9番目), 他11名
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] Peg-IFN/Ribavirin非著効例に対する再治療について-多施設(OLF)共同研究- (2010)
  • Author(s): 小瀬嗣子、木曽真一, (13番目), 他15名
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] Genotype2型C型肝炎non-RVR症例に対するPeg-IFN/Ribavirin長期投与の有用性について (2010)
  • Author(s): 井上裕子、木曽真一, (16番目), 他18名
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] 糖転移酵素N-アセチルグルコサミン転移酵素V(GnT-V)は肝線維化を抑制する (2010)
  • Author(s): 森華奈子、木曽真一, (8番目), 他8名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪府大阪市
• [Presentation] シンポジウム メタボリック症候群における肝障害検診受診者における肝機能検査値と内蔵脂肪面積、ウエスト周囲系、BMI、血清亜ヂィポネクチン値の相関についての疫学的検討 (2009)
  • Author(s): 鎌田佳宏, 木曽真一, 林紀夫
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-14
• [Presentation] 糖転移酵素N-アセチルグルコサミン転写酵素V(GnT-V) は肝星細胞におけるコラーゲンIの遺伝子発現を抑制する (2009)
  • Author(s): 森華奈子, 吉田雄一 (5番目), 木曽真一 (6番目), 他5名
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] 慢性膵炎の病態形成におけるアディポネクチンの意義 (2009)
  • Author(s): 山田拓也, 木曽真一 (6番目), 筒井秀作 (11番目), 他9名
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都
• [Presentation] NASH進展に対するアディポネクチンの予防効果について (2009)
  • Author(s): 福島寿一, 吉田雄一 (7番目), 木曽真一 (9番目), 他7名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] ラミブジンからエンテカビルへの切り替え症例におけるラミブジン非耐性B型慢性肝疾患の治療成績―OLF多施設共同研究 (2009)
  • Author(s): 倉繁奈緒, 木曽真一 (4番目), 他16名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] B型肝炎ウイルスキャリア急性増悪による劇症化予防に対する早期免疫抑制療法の有効性評価―劇症肝炎治療の標準化に向けた研究班の現状報告― (2009)
  • Author(s): 遠藤龍人, 木曽真一 (3番目), 他6名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] Gabファミリーアダプター蛋白のマウス肝再生過程における役割の解析 (2009)
  • Author(s): 吉田雄一, 筒井秀作 (9番目), 木曽真一 (10番目), 他8名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] 糖転移酵素N-アセチルグルコサミン転写酵素V (GnT-V) は肝星細胞におけるコラーゲンIの遺伝子発現を抑制する (2009)
  • Author(s): 森華奈子, 吉田雄一 (6番目), 木曽真一 (7番目), 他6名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] 難治性C型肝炎に対するPeg-IFN/Ribavirin 併用療法におけるHCVコア領域アミノ酸変異と治療反応性ならびに治療後再燃との関連について (2009)
  • Author(s): 小瀬嗣子, 木曽真一 (9番目), 他11名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] 難治性C型肝炎に対するPeg-IFN/Ribavirin 併用療法における再燃予測とその対策―多施設 (OLF) 共同研究― (2009)
  • Author(s): 小瀬嗣子, 木曽真一 (17番目), 他19名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] 一般健常者における肝機能検査値と内蔵脂肪面積、血清アディポネクチン値の相関についての疫学的検討 (2009)
  • Author(s): 鎌田佳宏, 木曽真一 (2番目), 吉田雄一 (6番目), 他8名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] 自己免疫性肝炎の新しい国際的診断基準についての検討 (2009)
  • Author(s): 金子晃, 木曽真一 (8番目), 他10名
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
• [Presentation] Gabファミリー蛋白の肝再生への関与の検討 (2009)
  • Author(s): 佐治雪子, 吉田雄一 (2番目), 木曽真一 (10番目), 他8名
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
• [Presentation] 慢性膵炎の病態形成におけるアディポネクチンの意義 (2009)
  • Author(s): 山田拓也, 木曽真一 (6番目), 筒井秀作 (11番目), 他9名
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
• [Presentation] 分子シャペロン Oxygen-regulated protein 150 (ORP150) は飽和脂肪酸負荷によるマウス肝由来細胞株の小胞体ストレス起因性アポトーシスを抑制する (2009)
  • Author(s): 松本仁, 吉田雄一 (4番目), 木曽真一 (5番目), 他3人
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
• [Presentation] 肝線維化進展C型肝炎に対する Peg IFN/RBV併用療法における治療効果関連因子の検討 (2009)
  • Author(s): 小瀬嗣子, 吉田雄一 (14番目), 木曽真一 (16番目), 他17名
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
• [Presentation] Adipnectin prevents progression of nonalcoholic steatohepatitis in mice by regulating oxidative stress and kupffer cell phenotype polarization (2009)
  • Author(s): 福島寿一, 吉田雄一 (4番目), 木曽真一 (8番目), 他10名
  • Organizer: 第60回米国肝臓病学会
  • Place of Presentation: 米国ボストン
• [Presentation] Viseral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction-an epidemiologic study of 3827 japanese subjects (2009)
  • Author(s): Y Kamada, Y Yoshida (7番目), S Kiso (8番目), 他7名
  • Organizer: 第60回米国肝臓病学会
  • Place of Presentation: 米国ボストン
• [Presentation] Factors affecting efficacy in patients with genotype2 chronic hepatitsus C treated by peginterferon alpa-2B and ribavirin : reducing drug doses has no impact on rapid and sustained virological responses (2009)
  • Author(s): Y Inoue, S Kiso (20番目), 他22名
  • Organizer: 第60回米国肝臓病学会
  • Place of Presentation: 米国ボストン
• [Presentation] Prediction of early response to pegylated interferon and ribavirin in chronic hepatitis C based on amino acid substitutions in the viral core region (2009)
  • Author(s): Y Inoue, S Kiso (10番目), 他12名
  • Organizer: 第60回米国肝臓病学会
  • Place of Presentation: 米国ボストン
• [Presentation] Gab family scaffording adaptor proteins mediate signals required for liver regeneration through MAPK/ERK activation (2009)
  • Author(s): Y Yoshida, S Kiso (7番目), 他6名
  • Organizer: 第60回米国肝臓病学会
  • Place of Presentation: 米国ボストン
• [Book] 炎症・再生医学事典 松島網治、西脇 徹編集 上皮増殖因子 (EGF) (2009)
  • Author(s): 木曽真一, ほか
  • Total Pages: 584
  • Publisher: 朝倉書店
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm