| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
This model mouse developed enhanced fatty acid synthesis and its beta-oxidation at the age of 8 weeks. These changes resulted in inflammatory cell infiltration induced by enhanced mRNA expression of scavenger receptor, catalase, IL-1, and IL-8. Supplementation of estradiol attenuated these changes significantly. Accelerated PPAR-alpha is a well-known risk factor for the development of hepatocellular carcinoma and its effective attenuation in such situation could be a novel strategy for the management of NASH patients.
|
