Host factor targeting newly developed treatment for HCV

• Project/Area Number: 21590860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Showa University
• Principal Investigator: INOUE Kazuaki 昭和大学, 医学部, 准教授 (90232529)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: HCV / サイクロフィリン / 宿主因子 / 抗ウイルス剤

Research Abstract

About 200million people are suffering from Hepatitis C virus infection that leads to hepatocellular carcinoma and chronic liver failure. Effectiveness of standard of care is not so sufficient to cure the intractable cases. We have searched for new lead compound targeting host factor that is related to HCV replication using new peptide library. Now we are characterizing new compounds.

Research Products

• [Journal Article] Localization and distribution of viral genomes and proteins are helpful to understand pathogenesis of hepatitis (2011)
  • Author(s): Inoue K, Yoshiba M, Kohara M
  • Journal Title: Global Antiviral Journal Volume: 7(Suppl. 1) Pages: 99-99
• [Journal Article] C型慢性肝炎の新規治療薬 (2011)
  • Author(s): 井上和明、高橋寛、与芝真彰
  • Journal Title: 日消病会誌 Volume: 108 Pages: 1187-1199
  • NAID: 10030297649
  • Peer Reviewed
• [Journal Article] New treatment strategy for fulminant hepatitis in Japan (2010)
  • Author(s): Inoue K, Yamamura E, Sakiyama, A, Kuroda T, Yoshiba M
  • Journal Title: Hepatol Int Volume: 4 Pages: 80-81
• [Journal Article] Prediction and early intensive medical care prevented development of fulminant hepatic failure and improved survival rate (2010)
  • Author(s): Inoue K, Yamamura E, Asonuma K, Takegoshi J, Yoshiba M
  • Journal Title: Hepatol Int Volume: 4 Pages: 279-279
• [Journal Article] Liver support systems as perioperative care in liver transplantation-historical perspective and recent progress in Japan-Minerva Gastroenterol Dietol (2010)
  • Author(s): Inoue K, Watanabe T, Hirasawa H, Yoshiba M
  • Volume: 56
  • Pages: 345-353
• [Journal Article] Japanese-style intensive medical care improves prognosis for acute liver failure and the perioperative management of liver transplantation (2010)
  • Author(s): Inoue K, Watanabe T, Maruoka N, Kuroki Y, Takahashi H, Yoshiba M
  • Journal Title: Transplant Proc Volume: 42 Pages: 4109-4112
• [Journal Article] Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization (2010)
  • Author(s): Nuriya H, Inoue K, Tanaka T, Hayashi Y, Hishima T, Funata N, Kaji K, Hayashi S, Kaneko S, Kohara M
  • Journal Title: J Clin Microbiol Volume: 48 Pages: 3843-3851
• [Journal Article] Liver support systems as perioperative care in liver transplantation-historical perspective and recent progress in Japan- (2010)
  • Author(s): Inoue K, Watanabe T, Hirasawa H, Yoshiba M.
  • Journal Title: Minerva Gastroenterol Dietol Volume: 56 Pages: 345-353
  • Peer Reviewed
• [Journal Article] Prediction and early intensive medical care prevented development of fulminant hepatic failure and improved survival rate (2010)
  • Author(s): Inoue K, Yamamura E, Asonuma K, Takegoshi J, Yoshiba M.
  • Journal Title: Hepatol Int 4 Pages: 279-279
  • Peer Reviewed
• [Journal Article] New treatment strategy for fulminant hepatitis in Japan (2010)
  • Author(s): Inoue K, Yamamura E, Sakiyama, A, Kuroda T, Yoshiba M.
  • Journal Title: Hepatol Int 4 Pages: 80-81
  • Peer Reviewed
• [Presentation] Localization anddistribution of viral genomes and proteins are helpful to understand pathogenesis of hepatitis (2011)
  • Author(s): Inoue K, Yoshiba M, Kohara M
  • Organizer: HEP DART 2011
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2011-12-05
• [Presentation] Appropriate Liver Support Systems as Perioperative Care in Liver Transplantation Improves Survival (2011)
  • Author(s): Inoue K.
  • Organizer: The 2011 Joint International Congrerss of ILTS, ELITA, & LICAGE
  • Place of Presentation: Valencia, Spain
  • Year and Date: 2011-06-24
• [Presentation] Change in MELD score is a useful tool of Liver transplantation for patients with fulminant hepatic failure under ALS (2011)
  • Author(s): Inoue K, Yoshiba M.
  • Organizer: The 21st Conference of the Asian Pacific Association for the Study of the Liver (APASL 2011)
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2011-02-18
• [Presentation] Sophistiated in situ PCR and immunohistochemistry is helpful to understand pathogenesis of chronic hepatitis and fulminant hepatitis (2011)
  • Author(s): Inoue K, Yoshiba M, Kohara M
  • Organizer: The 62nd Annual Meeting of the American Association for the Liver Diseases
  • Place of Presentation: San Francisco, U. S. A
• [Presentation] New treatment strategy for fulminant hepatitis in Japan (2010)
  • Author(s): Inoue K, Yamamura E, Sakiyama, A, Kuroda T, Yoshiba M
  • Organizer: The 20th Conference of the APASL(The Asian Pacific Association for the Study of the Liver)
  • Place of Presentation: Beijing, China
• [Presentation] Japanese style intensive medical care solves the shortage of organ donor and improves perioperative care of liver transplantation (2010)
  • Author(s): Inoue K, Watanabe T
  • Organizer: XXIII International Congress of The Transplantation Society
  • Place of Presentation: Vancouver, Canada
• [Presentation] Originally developed intensive medical care for fulminant hepatic failure improved patients'survival rate and also safely bridge patients to liver transplantation (2010)
  • Author(s): Inoue K, Yamamura E, Watanabe T, Yoshiba M
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, U. S. A.
• [Presentation] Cyclophilins are essential host factors for HCV replication : The required level varies with HCV clone (2009)
  • Author(s): Inoue K, Watanabe T, Yoshiba M, Kohara M.
  • Organizer: 44th Annual Meeting of the European Association for the Study of the Liver
  • Place of Presentation: コペンハーゲン
  • Year and Date: 2009-04-23
• [Presentation] Cyclophilins are essential host factors for HCV replication (2009)
  • Author(s): Inoue K, Watanabe T, Yoshiba M, Kohara M
  • Organizer: The required level varies with HCV clone. 44th Annual Meeting of the European Association for the Study of the Liver
  • Place of Presentation: Copenhagen, Norway