Growth inhibition of hepatocellular carcinoma by the regulation of signal pathway of the hepatoma-derived growth factor
| Project/Area Number |
21590863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMANISHI Hiroyasu 兵庫医科大学, 医学部, 講師 (60340957)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肝癌由来増殖因子(HDGF) / 肝細胞癌 / 血管新生 / HDGF / 細胞増殖 / ELISA / シグナル伝達 / 腫瘍マーカー / 診断 |
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| Research Abstract |
Hepatoma-derived growth factor(HDGF) is a new molecule that we identified as a novel growth factor. Down-regulation of HDGF resulted in the suppressive effects on the proliferation of the hepatocelluar carcinoma(HCC) cells. Vitamin K could reduce HDGF expression through the transcriptional suppression of HDGF promoter. Various factors which are involved in the angiogeniesis and cellular growth were found as potential target molecules of HDGF. Increased plasma HDGF concentration was related to the HCC development and early recurrence after the treatment. These findings should lead to the new therapy for HCC by the regulation of HDGF expression and the signal transduction.
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Report
(4 results)
Research Products
(37 results)
