Growth inhibition of hepatocellular carcinoma by the regulation of signal pathway of the hepatoma-derived growth factor

• Project/Area Number: 21590863
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hyogo Medical University
• Principal Investigator: ENOMOTO Hirayuki 兵庫医科大学, 医学部, 講師 (40449880)
• Co-Investigator(Kenkyū-buntansha): IMANISHI Hiroyasu 兵庫医科大学, 医学部, 講師 (60340957)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肝癌由来増殖因子(HDGF) / 肝細胞癌 / 血管新生 / HDGF / 細胞増殖 / ELISA / シグナル伝達 / 腫瘍マーカー / 診断

Research Abstract

Hepatoma-derived growth factor(HDGF) is a new molecule that we identified as a novel growth factor. Down-regulation of HDGF resulted in the suppressive effects on the proliferation of the hepatocelluar carcinoma(HCC) cells. Vitamin K could reduce HDGF expression through the transcriptional suppression of HDGF promoter. Various factors which are involved in the angiogeniesis and cellular growth were found as potential target molecules of HDGF. Increased plasma HDGF concentration was related to the HCC development and early recurrence after the treatment. These findings should lead to the new therapy for HCC by the regulation of HDGF expression and the signal transduction.

Research Products

• [Journal Article] Hepatoma-Derived Growth Factor in Carcinogene-sis and Cancer Progression (2011)
  • Author(s): Nakamura H, Enomoto H
  • Journal Title: CurrentDrug Therapy Volume: 6巻 Issue: 4 Pages: 278-285
  • DOI: 10.2174/157488511798109574
  • Peer Reviewed
• [Journal Article] Role of Hepatoma-derived Growth Factor(HDGF) in Hepatocellular carcinoma (2011)
  • Author(s): Enomoto H., Nakamura H., Nishiguchi S
  • Journal Title: Current Research in Gastroenterology & Hepatology Volume: 5巻 Pages: 19-26
  • Peer Reviewed
• [Journal Article] The role of Hepatoma-derived Growth Factor(HDGF) in cancer development and progression (2011)
  • Author(s): Enomoto H., Nakamura H., Nishiguchi S
  • Journal Title: Current Research in Cancer Volume: 5巻 Pages: 11-25
  • Peer Reviewed
• [Journal Article] Role of Hepatoma-derived growth factor (HDGF) in Hepatocellular carcinoma (2011)
  • Author(s): Enomoto H, Nakamura H, Nishiguchi S
  • Journal Title: Current Research in Gastroenterology & Hepatology Volume: 5 Pages: 19-26
• [Journal Article] The Role of Hepatoma-derived Growth Factor (HDGF) in cancer development and progression (2011)
  • Author(s): Enomoto H, Nakamura H, Nishiguchi S
  • Journal Title: Current Research in Cancer Volume: 5 Pages: 11-25
• [Journal Article] Role of Hepatoma-derived Growth Factor in Cancer (2010)
  • Author(s): Nakamura H., Weidong L., Enomoto H.
  • Journal Title: Trends in Cancer Research Volume: 5巻 Pages: 1-11
  • Peer Reviewed
• [Journal Article] A higher expression of hepatoma-derived growth factor in hepato-celular carcinoma cells and more tumor growth in vivo (2010)
  • Author(s): Liu W., Nakamura H., Deng H., Enomoto H., et al.
  • Journal Title: Trends in Cancer Research Volume: 5巻 Pages: 29-36
  • Peer Reviewed
• [Journal Article] Role of Hepatoma-derived Growth Factor in hepatocyte proliferation and differentiation (2010)
  • Author(s): Enomoto H., Nakamura H., Nishiguchi S
  • Journal Title: Current Research in Hepatology Volume: 4巻 Pages: 79-88
  • Peer Reviewed
• [Journal Article] 自己免疫性肝炎に発症した肝細胞癌にUFT-E投与が有効であった1例 (2010)
  • Author(s): 榎本平之、石井昭生、今西宏安, 他
  • Journal Title: 癌と化学療法 Volume: 37巻 Pages: 919-922
  • URL: http://www.pieronline.jp/content/article/0385-0684/37050/919
  • Peer Reviewed
• [Journal Article] A higher expression of hepatoma-derived growth factor in hepatocelular carcinoma cells and more tumor growth in vivo. (2010)
  • Author(s): Liu W., Nakamura H., Deng H., Enomoto H., et al.
  • Journal Title: Trends in Cancer Research Volume: 5 Pages: 29-36
  • Peer Reviewed
• [Journal Article] Role of Hepatoma-derived Growth Factor in hepatocyte proliferation and differentiation. (2010)
  • Author(s): Enomoto H., Nakamura H., Nishiguchi S.
  • Journal Title: Current Research in Hepatology Volume: 4 Pages: 79-88
  • Peer Reviewed
• [Journal Article] Partial blockage of hepatocyte maturation in hepatoma-derived growth factor transgenic mice (2009)
  • Author(s): Enomoto H., Nakamura H., Komatsu-Kanatani. N, et al.
  • Journal Title: World Journal of Hepatology Volume: 1巻 Issue: 1 Pages: 98-102
  • DOI: 10.4254/wjh.v1.i1.98
  • Peer Reviewed
• [Journal Article] Involvement of Hepatoma-derived Growth Factor in the growth of hepatocytes during liver developmentand regeneration (2009)
  • Author(s): Enomoto H., Nakamura H., Nishiguchi S
  • Journal Title: Current Research in Hepatology Volume: 3巻 Pages: 27-35
  • Peer Reviewed
• [Journal Article] Partial blockage of hepatocyte maturation in hepatoma-derived growth factor transgenic mice (2009)
  • Author(s): Enomoto H., Nakamura H., et.al
  • Journal Title: World Journal of Hepatology 1 Pages: 98-102
  • Peer Reviewed
• [Journal Article] Involvement of Hepatoma-derived Growth Factor in the growth of hepatocytes during liver development and regeneration. (2009)
  • Author(s): Enomoto H., Nakamura H., Nishiguchi S.
  • Journal Title: Current Research in Hepatology 3 Pages: 27-35
  • Peer Reviewed
• [Journal Article] 肝細胞癌の増殖におけるHDGF(Hepatoma-derived growth factor)の役割 (2009)
  • Author(s): 榎本平之、中村秀次、今西宏安, 他
  • Journal Title: 消化器疾患におけるエピゲノミクスとゲノミクス Pages: 199-201
• [Presentation] Hepatoma-derived growth factor as a potential target molecule for the treatment of hepatocellular carcinoma (2011)
  • Author(s): Enomoto H., Nakamura H., Imanishi H., et al
  • Organizer: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2011)
  • Place of Presentation: San Francisco
  • Year and Date: 2011-11-06
• [Presentation] Hepatoma-derived growth factor as a potential target molecule for the treatment of hepatocellular carcinoma (2011)
  • Author(s): Enomoto H, Nakamura H, Imanishi H, et al
  • Organizer: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD2011)
  • Place of Presentation: San Francisco
  • Year and Date: 2011-11-06
• [Presentation] C型慢性肝炎組織に生じるミトコンドリア遺伝子異常と発癌に関する検討 (2011)
  • Author(s): 榎本平之、会澤信弘、西口修平
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02
• [Presentation] 肝癌細胞増殖因子と血管新生因子としてのHepatoma-derived growth factor:治療標的の可能性に関する検討 (2011)
  • Author(s): 榎本平之、今西宏安, 他
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02
• [Presentation] 慢性肝疾患組織におけるミトコンドリア遺伝子異常と肝発癌 (2011)
  • Author(s): 会澤信弘、榎本平之、今西宏安, 他
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-15
• [Presentation] 未分化肝細胞の増殖因子Hepatoma-derived growth factorは、血管新生誘導を介して腫瘍増殖に関与する (2010)
  • Author(s): 榎本平之、中村秀次、今西宏安, 他
  • Organizer: 第18回浜名湖シンポジウム
  • Place of Presentation: 浜松
  • Year and Date: 2010-12-15
• [Presentation] 未分化肝細胞の増殖因子未分化肝細胞の増殖因子Hepatoma-derived growth factorの腫瘍間質非上皮細胞への作用に関する検討 (2010)
  • Author(s): 榎本平之、中村秀次、今西宏安, 他
  • Organizer: 第14回日本肝臓学会大会(JDDW2010)
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] 未分化肝細胞の増殖因子Hepatoma-derived growth factorの腫瘍間質非上皮細胞への作用に関する検討 (2010)
  • Author(s): 榎本平之、中村秀次、今西宏安, 他
  • Organizer: 第14回日本肝臓学会大会(JDDW2010)
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] 血漿中の肝癌由来増殖因子HDGFは肝細胞癌の再発・予後マーカーとなりうるか (2010)
  • Author(s): 中村秀次、榎本平之、西口修平
  • Organizer: 第14回日本肝臓学会大会(JDDW2010)
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 血漿中の肝癌由来増殖因子HDGFは肝細胞癌の再発・予後マーカーとなりうるか? (2010)
  • Author(s): 中村秀次、榎本平之、西口修平
  • Organizer: 第14回日本肝臓学会大会(JDDW2010)
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 血漿中の肝癌由来増殖因子HDGFは進行肝癌の生命予後予測因子になりうるか (2010)
  • Author(s): 中村秀次、榎本平之、今西宏安, 他
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-27
• [Presentation] 血漿中の肝癌由来増殖因子HDGFは進行肝癌の生命予後予測因子になりうるか? (2010)
  • Author(s): 中村秀次、榎本平之、今西宏安, 他
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-27
• [Presentation] 肝癌症例におけるHepatoma-derived growth factor(HDGF)の血中濃度測定に関する検討 (2010)
  • Author(s): 榎本平之、中村秀次、西口修平
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-24
• [Presentation] 早期肝細胞癌における血漿中の肝癌由来増殖因子HDGFの測定意義 (2009)
  • Author(s): 中村秀次、榎本平之、今西宏安, 他
  • Organizer: 第13回日本肝臓学会大会(JDDW2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] 未分化肝細胞の増殖因子Hepatoma-derived growth factorは、血管新生誘導を介して腫瘍増殖に関与する (2009)
  • Author(s): 榎本平之、中村秀次、西口修平
  • Organizer: 第51回日本消化器病学会大会(JDDW2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] 血漿中の肝癌由来増殖因子HDGFは肝癌の腫瘍マーカーとなりうるか (2009)
  • Author(s): 中村秀次、榎本平之、今西宏安, 他
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04
• [Presentation] HDGF抑制による肝細胞癌細胞の腫瘍原性の阻害(Down-regulation of HDGF inhibits tumorigenicity of hepatocellular carcinoma cells) (2009)
  • Author(s): 劉衛東、中村秀次、榎本平之, 他
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04
• [Presentation] 血漿中の肝癌由来増殖因子HDGFは肝癌の腫瘍マーカーとなりうるか? (2009)
  • Author(s): 中村秀次、榎本平之、今西宏安, 他
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04
• [Book] 未分化肝細胞の増殖因子Hepatoma-derived growth factorは、血管新生誘導を介して腫瘍増殖に関与する、消化器疾患と幹細胞その基礎と臨床 (2011)
  • Author(s): 榎本平之、中村秀次、今西宏安, 他
  • Publisher: アークメディア
• [Book] 第18回浜名湖シンポジウム記録集消化器疾患と幹細胞その基礎と臨床 (2011)
  • Author(s): 榎本平之、中村秀次、今西宏安, 他
  • Total Pages: 203
  • Publisher: 未分化肝細胞の増殖因子Hepatoma-derived growth factorは、血管新生誘導を介して腫瘍増殖に関与する
• [Book] 肝細胞癌の増殖におけるHDGF(Hepatoma-derived growth factor)の役割、消化器疾患におけるエピゲノミクスとゲノミクス (2009)
  • Author(s): 榎本平之、中村秀次、今西宏安, 他
  • Publisher: アークメディア