| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Chymase assay method was established using the specific chymase inhibitor with modified angiotensinI(AngI). Analysis in circulating mononuclear leukocyte(CML) of the patients post myocardial infarction(MI) revealed significant increase in acute phase(1-2 days) and the level of increase was positively correlated with the MI severity. In the analysis of stable angina patient chymase activity in CML was significantly higher in male and positively correlated with white blood cell number, c-reactive protein, HOMA index, degree of chronic kidney disease(CKD), suggesting that mild inflammatory status, glucose intolerance or CKD facilitate chymase levels in CML. In collaborative work with Ryuku University acute venous infusion of free fatty acid significantly increased serine protease dependent Ang II forming activity in CML, which was associated with endothelial dysfunction. In collaborative work with Kagawa University unilateral urethral clipping was associated with increased chymase activity only in the affected kidney and increased renal Ang IIlevels.
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