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Chronic infection and immune response in COPD patients

Research Project

Project/Area Number 21590964
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

MURO Shigeo  京都大学, 医学研究科, 講師 (60344454)

Co-Investigator(Kenkyū-buntansha) ITO Isao  京都大学, 医学研究科, 助教 (40447959)
NARUISHI Koji  岩手医科大学, 歯学部, 准教授 (00346446)
SATO Susumu  京都大学, 医学研究科, 助教 (40378691)
伊藤 功朗  京都大学, 医学研究科, 助教 (40447975)
黄瀬 大輔  京都大学, 医学研究科, 医員 (50572418)
星野 勇馬  京都大学, 医学研究科, 助教 (00378746)
小川 恵美子  滋賀医科大学, 保健管理センター, 講師 (00378671)
Co-Investigator(Renkei-kenkyūsha) TAKASHIBA Shogo  岡山大学, 歯学部, 教授 (50226768)
MISHIMA Michiaki  京都大学, 医学研究科, 教授 (60190625)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsCOPD増悪 / 慢性感染 / 宿主免疫 / 感染 / 慢性閉塞性肺疾患 / 気道炎症 / 歯周病 / MAPK
Research Abstract

Our prospective observational study including 93 COPD patients showed that the numbers of exacerbations and the rate of individuals with frequent exacerbations(at least two per year) were significantly lower in patients with higher IgG titer than those with normal IgG titer. Thus in contrast to our hypothesis, normal-IgG titer for periodontitis-related antibody can be an independent predictor of frequent exacerbations suggesting that humoral immune response associates with COPD exacerbations. We also found that COPD exacerbation accelerated the emphysema progression in spite of current additional therapy during exacerbations.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (22 results)

  • [Journal Article] Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease2012

    • Author(s)
      Tanabe N, Muro S, Tanaka S, Sato S, Oguma T, Kiyokawa H, Takahashi T, Kinose D, Hoshino Y, Kubo T, Ogawa E, Hirai T, Mishima M. Respir Res
    • Journal Title

      Epub ahead of print

      Volume: 13(1) Issue: 1 Pages: 31-31

    • DOI

      10.1186/1465-9921-13-31

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computed tomography assessment of pharmacological lung volume reduction induced by bronchodilators in COPD2012

    • Author(s)
      Tanabe N, Muro S, Oguma T, Sato S, Kiyokawa H, Takahashi T, Kudo M, Kinose D, Kubo T, Hoshino Y, Ogawa E, Hirai T, Mishima M. COPD
    • Journal Title

      COPD

      Volume: 9 Issue: 4 Pages: 1-8

    • DOI

      10.3109/15412555.2012.674986

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress induced Interleukin-32 mRNA expression in human bronchial epithelial cells2012

    • Author(s)
      Kudo M, Ogawa E, Kinose D, Haruna A, Takahashi T, Tanabe N, Marumo S, Hoshino Y, Hirai T, Sakai H, Muro S, Date H, Mishima M
    • Journal Title

      Respir Res

      Volume: 13 Issue: 1 Pages: 19-19

    • DOI

      10.1186/1465-9921-13-19

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of COPD Exacerbations on Osteoporosis Assessed by Chest CT Scan2012

    • Author(s)
      Kiyokawa H, Muro S, Oguma T, Sato S, Tanabe N, Takahashi T, Kudo M, Kinose D, Kondoh H, Kubo T, Hoshino Y, Ogawa E, Hirai T, Mishima M
    • Journal Title

      Epub

      Volume: 9(3) Issue: 3 Pages: 235-42

    • DOI

      10.3109/15412555.2011.650243

    • NAID

      120004873856

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population2012

    • Author(s)
      Kinose D, Ogawa E, Hirota T, Ito I, Kudo M, Haruna A, Marumo S, Hoshino Y, Muro S, Hirai T, Sakai H, Date H, Tamari M, Mishima M
    • Journal Title

      Respirology

      Volume: 17(1) Issue: 1 Pages: 164-71

    • DOI

      10.1111/j.1440-1843.2011.02069.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease2011

    • Author(s)
      Tanabe N, Muro S, Hirai T, Oguma T, Terada K, Marumo S, Kinose D, Ogawa E, Hoshino Y, Mishima M
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 183(12) Issue: 12 Pages: 1653-9

    • DOI

      10.1164/rccm.201009-1535oc

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease2011

    • Author(s)
      Tanabe N, Muro S, et.al
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 15 Issue: 12 Pages: 1653-9

    • DOI

      10.1164/rccm.201104-0615ed

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide induced connective tissue growth factor gene expression in human bronchial epithelial cells2010

    • Author(s)
      Nishioka M, Ogawa E, Kinose D, Haruna A, Ohara T, Ito I, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Hirai T, Muro S, Mishima M
    • Journal Title

      Respirology

      Volume: 15(4) Pages: 669-76

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CT scan findings of emphysema predict mortality in COPD2010

    • Author(s)
      Haruna A, Muro S, Nakano Y, Ohara T, Hoshino Y, Ogawa E, Hirai T, Niimi A, Nishimura K, Chin K, Mishima M
    • Journal Title

      Chest

      Volume: 138(3) Issue: 3 Pages: 635-40

    • DOI

      10.1378/chest.09-2836

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between peripheral airway function and patient-reported outcomes in COPD : a cross-sectional study2010

    • Author(s)
      Haruna A, Oga T, Muro S, Ohara T, Sato S, Marumo S, Kinose D, Terada K, Nishioka M, Ogawa E, Hoshino Y, Hirai T, Chin K, Mishima M
    • Journal Title

      BMC Pulm Med

      Volume: 10 Issue: 1 Pages: 10-10

    • DOI

      10.1186/1471-2466-10-10

    • NAID

      120004754366

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal swallowing reflex and COPD exacerbations2010

    • Author(s)
      Terada K, Muro S, Ohara T, Kudo M, Ogawa E, Hoshino Y, Hirai T, Niimi A, Chin K, Mishima M
    • Journal Title

      Chest

      Volume: 137(2) Issue: 2 Pages: 326-32

    • DOI

      10.1378/chest.09-0482

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide induced connective tissue growth factor gene expression in human bronchial epithelial cells.2010

    • Author(s)
      西岡慶喜、小川恵美子、室繁郎
    • Journal Title

      Respirology

      Volume: 15(4) Pages: 134-138

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CT scan findings of emphysema predict mortality in COPD.2010

    • Author(s)
      春名茜、室繁郎
    • Journal Title

      Chest

      Volume: 138(3) Pages: 635-640

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between peripheral airway function and patient-reported outcomes in COPD2010

    • Author(s)
      Haruna A, Muro S, et al
    • Journal Title

      BMC Pulm Med 10

      Pages: 1-10

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cough-reflex sensitivity to inhaled capsaicin in COPD associated with increased exacerbation frequency2009

    • Author(s)
      Terada K, Muro S, Ohara T, Haruna A, Marumo S, Kudo M, Ogawa E, Hoshino Y, Hirai T, Niimi A, Mishima M
    • Journal Title

      Respirology

      Volume: 14(8) Issue: 8 Pages: 1151-5

    • DOI

      10.1111/j.1440-1843.2009.01620.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal awallowing reflex and COPD exacerbations.2009

    • Author(s)
      Terada K, Muro S, et. al.
    • Journal Title

      Chest 137

      Pages: 326-332

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CT emphysema predicts mortality in COPD

    • Author(s)
      Haruna A, Muro S, et al
    • Journal Title

      Chest (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Annual Changes Of "Lung Age". Validation Of Lung Age Equation By 5-Year Follow Up Study In Japan2012

    • Author(s)
      S. Sato, S. Muro, T. Takahashi, T. Hirai, M. Mishima, A. Sato
    • Organizer
      American Thoracic Society Poster Session
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2012-05-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Correlation of Vascular Endothelial Growth Factor Receptor 2 With Pulmonary Function And Emphysematous Change In Early Chronic Obstructive Pulmonary Disease2012

    • Author(s)
      T. Takahashi, E. Ogawa, A. Haruna, M. Kudo, H. Kiyokawa, N. Tanabe, D. Kinose, S. Sato, Y. Hoshino, T. Hirai, H. Sakai, Y. Nakano, S. Muro, M. Mishima
    • Organizer
      American Thoracic Society Poster Session
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2012-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of COPD Exacerbations On Osteoporosis Assessed By Chest CT Scan2012

    • Author(s)
      H. Kiyokawa, S. Muro, T. Oguma, S. Sato, N. Tanabe, T. Takahashi, M. Kudo, D. Kinose, Y. Hoshino, E. Ogawa, T. Hirai, M. Mishima
    • Organizer
      American Thoracic Society Poster Discussion Session
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2012-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Increased TLR3 Gene Expression In Epithelial Cells Of COPD Patients/D. Kinose2012

    • Author(s)
      E. Ogawa, S. Muro, W. M. Elliott, J. C. Hogg, M. Mishima
    • Organizer
      American Thoracic Society Thematic Poster Session
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2012-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Comorbidities of chronic obstructive pulmonary disease2012

    • Author(s)
      室繁郎
    • Organizer
      第52回日本呼吸器学会
    • Year and Date
      2012-04-22
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム「COPDの臨床的諸問題」2011

    • Author(s)
      室繁郎
    • Organizer
      第51回日本呼吸器学会
    • Year and Date
      2011-04-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Long Term Effect Of Tiotropium On Airway Dimension Assessed By Computed Tomography In COPD Patients2011

    • Organizer
      American Thoracic Society
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of thioredoxin-1 on accelerated emphysema progression in cigarette smoke-exposed mice challenged with polyinosine-polycytidylic acid2010

    • Author(s)
      N. Tanabe, Y. Hoshino, H. Kiyokawa, S. Marumo, E. Ogawa, S. Muro, T. Hirai, J. Yodoi, M. Mishima
    • Organizer
      European Respiratory Society
    • Year and Date
      2010-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] A single nucleotide polymorphism in NOD2 gene was associated with pathogenesis and severity of COPD2010

    • Author(s)
      D. Kinose, E. Ogawa, T. Hirota, I. Ito, S. Muro, Y. Hoshino, T. Hirai, H. Sakai, M. Tamari, M. Mishima
    • Organizer
      European Respiratory Society Barcelona
    • Year and Date
      2010-09-19
    • Related Report
      2011 Final Research Report
  • [Presentation] A single nucleotide polymorphism in NOD2 gene was associated with pathogenesis and severity of COPD2010

    • Author(s)
      黄瀬大輔、小川恵美子、室繁郎
    • Organizer
      ヨーロッパ呼吸器学会
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血清歯周病抗体価とCOPD(慢性閉塞性肺疾患)増悪との関連性2010

    • Author(s)
      高橋珠紀、室繁郎、三嶋理晃
    • Organizer
      第75回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2010-06-25
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Oxidative stress augmented IL-32 gene upregulation in airway epithelial cells2010

    • Author(s)
      M. Kudo, MD, E. Ogawa, MD, PhD, A. Haruna, MD, D. Kinose, MD., Y. Hoshino, MD, PhD, S. Muro, MD. PhD., T. Hirai, MD, PhD, M. Mishima, MD, PhD
    • Organizer
      American Thoracic Society
    • Year and Date
      2010-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Distinct responses against polyinosine-polycytidylic acid in smoke-exposed mouse strains with different susceptibility to emphysema2010

    • Author(s)
      N. Tanabe, MD, Y. Hoshino, MD, PhD, H. Kiyokawa, MD, S. Marumo, MD, E. Ogawa, MD, PhD, S. Muro, MD, PhD, T. Hirai, MD, PhD, M. Mishima, MD, PhD
    • Organizer
      American Thoracic Society
    • Year and Date
      2010-05-18
    • Related Report
      2011 Final Research Report
  • [Presentation] The effect of telling smokers their "lung age" on smoking quit rate at annual health checkup2010

    • Author(s)
      S. Marumo, MD1, S. Muro, MD. PhD. 1, A. Haruna, MD1, A. Sato, M. D., Ph. D. 2, E. Ogawa, MD, PhD1, Y. Hoshino, MD, PhD1, T. Hirai, MD, PhD1, M. Mishima, MD, PhD1, A. Sato, MD. PhD1
    • Organizer
      American Thoracic Society Thematic Poster Session
    • Year and Date
      2010-05-17
    • Related Report
      2011 Final Research Report
  • [Presentation] NOD2 SNPs associated with Crohn's disease were not found in Japanese COPD patients2010

    • Author(s)
      E. Ogawa, MD, PhD, M. Nishioka, MD., Y. Hoshino, MD, PhD, T. Hirai, MD, PhD, S. Muro, MD. PhD
    • Organizer
      American Thoracic Society Thematic Poster Session
    • Year and Date
      2010-05-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 医逆流症症状とCOPD増悪2009

    • Author(s)
      室繁郎
    • Organizer
      GERD研究会 第14回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 体質とCommon diseases体質とCOPD2009

    • Author(s)
      室繁郎
    • Organizer
      第59回日本体質医学会総会
    • Year and Date
      2009-07-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃食道逆流症症状とCOPD増悪2009

    • Author(s)
      D. Kinose, MD, E. Ogawa, MD, PhD, S. Muro, MD, PhD, A. Takahashi, MD, H. Sakai, MD, PhD, W. M. Elliott, PhD, J. C. Hogg, MD, PhD, M. Mishima, MD, PhD
    • Organizer
      第14回学術集会
    • Year and Date
      2009-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Three-Dimensional Lobar Distribution of Emphysema Assessed Using Computer Tomographic Data2009

    • Author(s)
      Three-Dimensional Lobar Distribution of Emphysema Assessed Using Computer Tomographic Data
    • Organizer
      Poster Discussion
    • Year and Date
      2009-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Increased NOD1 and NOD2 Gene Expressions in Bronchial Epithelial Cells in COPD2009

    • Author(s)
      D. Kinose, MD, E. Ogawa, MD, PhD, S. Muro, MD, PhD, A. Takahashi, MD, H. Sakai, MD, PhD, W. M. Elliott, PhD, J. C. Hogg, MD, PhD, M. Mishima, MD, PhD
    • Organizer
      Mini-Symposium
    • Year and Date
      2009-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Systemic Immune Activation by Polyinosine-Polycytidylic Acid Evokes Lung Inflammation Similar to COPD Exacerbation in Cigarette Smoke-Exposed Mice2009

    • Author(s)
      N. Tanabe, MD, Y. Hoshino, MD, Ph, S. Marumo, MD, I. Ito, MD, Ph, E. Ogawa, MD, Ph, S. Muro, MD, Ph, T. Hirai, MD, Ph, M. Mishima, MD, Ph
    • Organizer
      Thematic Poster Session
    • Year and Date
      2009-05-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Pathophysiology of Cigarette Smoke Induced Emphysema after Smoking Cessation in a Murine Model2009

    • Author(s)
      MD, A. Sato, MD, PhD, I. Ito, MD, PhD, E. Ogawa, MD, PhD, S. Muro, MD, PhD, T. Hirai, MD, PhD, M. Mishima, MD, PhD
    • Organizer
      Mini-Symposium
    • Year and Date
      2009-05-17
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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