The establishment of therapeutic strategy for pulmonary fibrosis and pulmonary hypertension in targeting endothelial-mesenchymal transition
| Project/Area Number |
21590987
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Yoshinori 名古屋大学, 大学院・医学系研究科, 教授 (20270986)
IMAIZUMI Kazuyoshi 藤田保健衛生大学, 大学院・医学研究科, 教授 (50362257)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 呼吸器病学 / 肺線維症 / 血管内皮間葉系細胞転換 / 線維芽細胞 / 低酸素 / 血管内皮細胞 |
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| Research Abstract |
Current evidence suggests that the pathogenesis of pulmonary fibrosis might be due to the heterogeneity of fibroblast origins. In this study, persistent tissue hypoxia might be involved in active fibrosis in an in vivo model of BLM-induced lung injury/fibrosis, likely due to endothelial-mesenchymal transition. These findings indicate that persistent tissue hypoxia as tissue microenvironment may promote secondary EMT and lung fibrosis. These also indicate the clue to understand the underlying mechanism of lung fibrosis, leading the new therapeutic strategy.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Involvement of the transcription factor twist in phenotype alteration throughe pithelial-mesenchymal transition in lung cancercells2011
Author(s)
Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.
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Journal Title
Mol Carcinog
Volume: E1
Issue: 5
Pages: 1-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinaseandc AMP-dependent mechanisms2011
Author(s)
Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, and Hasegawa Y
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Journal Title
Am J Respir Cell Mol Biol
Volume: 45(4)
Pages: 684-91
Related Report
Peer Reviewed
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