A crossover study of a traditional Asian medicine for Huntington's disease

• Project/Area Number: 21591107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: 独立行政法人国立病院機構西多賀病院 (2011); Tohoku University (2009-2010)
• Principal Investigator: IWASAKI Koh 独立行政法人国立病院機構西多賀病院, 臨床研究部, 臨床研修部長 (90396432)
• Co-Investigator(Kenkyū-buntansha): KIKUCHI Akio 東北大学, 医学研究科, 助教 (80463785)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 臨床神経治療学 / ハンチントン病 / 抑肝散 / 漢方 / 東洋医学 / 不随意運動 / ジストニア / 舞踏症状

Research Abstract

A two-way crossover study of a traditional Asian herbal medicine yokukansan(YKS) was conducted for Huntington's disease(HD). YKS showed a tendency for improvement of Total Unified Huntington's Disease Rating Scale, Maximal Chorea, and Maximal Dystonia.

Research Products

• [Journal Article] Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloidβproteins in amylod precursor protein transgenic mice (2011)
  • Author(s): Fujiwara H, Takayama S, Iwasaki K, Tabuchi M, Yamaguchi T, Sekiguchi K, Ikarashi Y, Kudo Y, Kase Y, Arai H, and Yaegashi N
  • Journal Title: Neuroscience Volume: Vol、180 Pages: 305-313
• [Journal Article] Open label trial to evaluate the efficacy and safety of yokukansan a traditional Asian medicine, in dementia with Lewy bodies (2011)
  • Author(s): Koh Iwasaki, Kenji Kosaka, Hideo Mori, Reina Okitsu, Katsutoshi Furukawa, Yuta Manabe, Mitsuhiro Yoshita,: Aya Kanamori, Nobuo Ito, Kenji Wada, MD, P hD, Michio Kitayama, MD, Jun Horiguchi, Shuhei Yamaguchi, Ryuji Fukuhara, Shinji Ouma, Seigo Nakano, Mamoru Hashimoto, Toru Kinoshita
  • Journal Title: JAGS Volume: 59(5) Pages: 936-938
• [Journal Article] Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice (2011)
  • Author(s): K.Iwasaki, et.al.
  • Journal Title: Neuroscience Volume: 180 Pages: 305-313
  • DOI: 10.1016/j.neuroscience.2011.01.064
  • Peer Reviewed
• [Journal Article] Open label trial to evaluate the efficacy and safety of yokukansan, a traditional Asian medicine, in dementia with Lewy bodies (2011)
  • Author(s): K.Iwasaki, et.al.
  • Journal Title: JAGS Volume: 59(5) Issue: 5 Pages: 936-938
  • DOI: 10.1111/j.1532-5415.2011.03373.x
  • Peer Reviewed
• [Presentation] A crossover study of a traditional Asian herbal medicine for Huntington's disease (2011)
  • Author(s): K.Iwasaki, A.Kikuchi
  • Organizer: The XIX World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: Shanghai
  • Year and Date: 2011-12-11
• [Presentation] A crossover study of a traditional Asian herbal medicine for Hutington's diseasePoster presentation (2011)
  • Author(s): Iwasaki K, et at
  • Organizer: The XIX World Congress on Parkinson's Disease and Ralated Disorders Shanghai
  • Place of Presentation: China Sunday DECEMBER
• [Presentation] Efficacy and safety of yokukansan, a traditional Asian medicine, for BPSD in Dementia with Lewy Bodies (2010)
  • Author(s): Iwasaki K, et at
  • Organizer: 7^<th> International Congress on Mental Dysfunctions & Other Non-Motor Features in PARKINSON's DISEASE
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-12-11
• [Remarks] 平成22年度はデータ収集と統計解析を行ったのみで、発表は行っていない。