| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Depression is known to be associated with an increased risk of type 2 diabetes. To reveal its pathophysiological mechanism, we investigated the changes in glucose metabolism in a mouse model of depression, and found that chronic social defeat stress caused depressive symptoms, the impairment of glucose tolerance and insulin resistance, probably through abnormal function of hypothalamic orexin system. Thus, hypothalamic orexin may be a novel target to treat type 2 diabetes associated with depression.
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