Pathophysiological roles of heparin cofactor II in cardiac remodeling and insulin resistance
| Project/Area Number |
21591140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
AIHARA Ken-ichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70372711)
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| Co-Investigator(Kenkyū-buntansha) |
AKAIKE Masashi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90271080)
IWASE Takashi 徳島大学, 病院, 助教 (10403718)
ENDOU Itsurou 徳島大学, 病院, 講師 (10432759)
HUJINAKA Yuichi 徳島大学, 病院, 講師 (30432751)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヘパリンコファクターII / トロンビン / 心筋リモデリング / インスリン抵抗性 / メタボリックシンドローム / 2型糖尿病 |
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| Research Abstract |
We hypothesized that thrombin inactivation ameliorate cardiac remodeling and diabetes. Angiotensin II accelerated cardiac concentric remodeling and larger left atrial volume with prominent interstitial fibrosis in heparin cofactor II(HCII), an endogenous thrombin inhibitor,-deficient mice than those in wild-type mice. And these cardiac phenotypes were caused by enhancement of NAD(P) H oxidase-transforming growth factor-beta1 pathway. In addition, we found that increased thrombin activity in adipose tissue contributes to the development of insulin resistance via enhancing MCP-1 production, leading to macrophage infiltration and insulin receptor substrate-1-Akt pathway inactivation.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors2011
Author(s)
Ise T, Aihara K, Sumitomo-Ueda Y, Yoshida S, Ikeda Y, Yagi S, Iwase T, Yamada H, Akaike M, Sata M, Matsumoto T
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Journal Title
Hypertens Res
Volume: 34
Issue: 2
Pages: 225-31
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice2010
Author(s)
Sumitomo-Ueda Y, Aihara K, Ise T, Yoshida S, Ikeda Y, Uemoto R, Yagi S, Iwase T, Ishikawa K, Hirata Y, Akaike M, Sata M, Kato S, Matsumoto T
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Journal Title
Hypertension
Volume: 56
Issue: 3
Pages: 430-6
DOI
Related Report
Peer Reviewed
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