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Functional analysis of parafibromin with activities of tumor suppressor and oncogene

Research Project

Project/Area Number 21591180
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionThe University of Tokushima

Principal Investigator

YOSHIMOTO Katsuhiko  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90201863)

Co-Investigator(Kenkyū-buntansha) IWATA Takeo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10350399)
MIZUSAWA Noriko  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80254746)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsがん遺伝子 / がん抑制遺伝子 / 副甲状腺腫瘍 / 内科 / 内分泌 / 腫瘍 / 副甲状腺 / miRNA / 癌遺伝子 / 癌抑制遺伝子
Research Abstract

We found a germ-line mutation(p. E29X) of the HRPT2 gene in one of three familial hyperparathyroidism families. We found reduced expression of U6 by over-expression of the HRPT2 gene. U6 is a small non-coding RNA and transcribed by RNA polymerase III. U6 is involved in splicing of mRNA, over-expressed in many tumors, and positively regulates cell growth. These results suggested that U6 might play an important role of regulation of parafibromin-related cell growth.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (16 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking2011

    • Author(s)
      H irata Y, Iwata T, Le CTH, Jambaldorj B, Teshigawara K, Harada N, Sakaue H, Sakai T, Yoshimoto K, Nakaya Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 405(1) Issue: 3 Pages: 96-101

    • DOI

      10.1371/journal.pone.0033402

    • NAID

      120006631415

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of aryl hydrocarbon receptor interacting protein(AIP) mutations in familial isolated pituitary adenoma families2010

    • Author(s)
      Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M, Akker S, Atkinson B, Aylwin S, Baldeweg S, Bevan J, Cheetham T, Chew S, Choudry K, Clayton R, Damjanovic S, Darzy K, Dattani M, Davis J, Drake W, Dzeranova L, Eden B, Eguchi K, Fica S, Flanagan D, Frohman L, Gadelha M, Gallego P, Glaz E, Goldman J, Goldstone T, Howlett T, Inder W, Iwata T, Kaplan F, Karavitaki N, Laws E, Lechan R, Levy M, Matsuno A, Miljic D, Modenesi S, Molitch M, Musat M, Orme S, Patocs A, Popovic V, Powell M, Quinton R, Randeva H, Ribeiro de Oliveira JR A, Schofl C, Soares B, Spada A, Strasburger C, Swords F, Tsagarakis St, Vaks V, Wass J, Widell H, Yarman S, Yoshimoto K
    • Journal Title

      Hum Mutat

      Volume: 31(8) Issue: 8 Pages: 950-960

    • DOI

      10.1002/humu.21292

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors2010

    • Author(s)
      Rahman MM, Qian ZR, Lu Wang E, Yoshimoto K, Nakasono M, Sultana R, Yoshida T, Hayashi T, Haba R, Ishida M, Okabe H, Sano T
    • Journal Title

      Hum Pathol

      Volume: 41(8) Pages: 1069-1078

    • URL

      http://dx.doi.org/10.1016/j.humpath.2010.01.011

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of HMGA1 correlates with tumour invasiveness and proliferation in human pituitary adenomas2010

    • Author(s)
      Wang EL, Qian ZR, Rahman MM, Yoshimoto K, Yamada S, Kud o E, Sano T
    • Journal Title

      H istopathology

      Volume: 56(4) Issue: 4 Pages: 501-509

    • DOI

      10.1111/j.1365-2559.2010.03495.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.2010

    • Author(s)
      Igreja S, et al
    • Journal Title

      Human Mutation

      Volume: 31 Pages: 950-960

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.2010

    • Author(s)
      Rahman MM, et al
    • Journal Title

      Human Pathology

      Volume: 41 Pages: 1069-1078

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of HMGA1 correlates with tumour invasiveness and proliferation in human pituitary adenomas.2010

    • Author(s)
      Wang EL, et al
    • Journal Title

      Histopathology

      Volume: 56 Pages: 501-509

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of p18(INK4C) is Down-regulated in Human Pituitary Adenomas2009

    • Author(s)
      Hossain MG, Iwata T, Mizusawa N, Qian ZR, Shima SW, Okutsu T, Yamada S, Sano T, Yoshimoto K
    • Journal Title

      Endocr Pathol

      Volume: 20(2) Issue: 2 Pages: 114-121

    • DOI

      10.1007/s12022-009-9076-0

    • NAID

      120005708870

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of p18INK4C is Down-regulated in Human Pituitary Adenomas.2009

    • Author(s)
      Hossain MG, et al.
    • Journal Title

      Endocr Pathol 20

      Pages: 114-121

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YKL-40 secreted from adipose tissue inhibits degradation of type I collagen.2009

    • Author(s)
      Iwata T, et al.
    • Journal Title

      Biochem Biophys Res Commun 388

      Pages: 511-516

    • NAID

      120005708871

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARγ2 and C/EBPα.2009

    • Author(s)
      Hossain MG, et al.
    • Journal Title

      J Biosci Bioeng 109

      Pages: 297-303

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] AIP遺伝子変異を認めなかった家族性下垂体腺腫の一例2012

    • Author(s)
      竹本潤哉、佐久間一基、京原麻由、滝口朋子、橋本直子、松澤陽子、齋藤淳、大村昌夫、吉本勝彦、山田正三、西川哲男
    • Organizer
      第12回日本内分泌学会関東甲信越支部学術集会
    • Place of Presentation
      ラフレさいたま(さいたま市)
    • Related Report
      2011 Final Research Report
  • [Presentation] 家族性先端巨大症2家系におけるAIP遺伝子の検討2012

    • Author(s)
      藤本寛太、浜本芳之、河崎祐貴子、本庶祥子、森可南子、龍岡久登、山田正三、岩田武男、吉本勝彦、越山裕行
    • Organizer
      第21回臨床内分泌代謝Update
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2011 Final Research Report
  • [Presentation] 原発性アルドステロン症・サブクリニカルCushing症候群を合併した家族性副甲状腺機能亢進症の一例2011

    • Author(s)
      安藤明彦、長坂昌一郎、齋藤芽里、山崎智行、高橋仁麗、野牛宏晃、大須賀淳一、水澤典子、吉本勝彦、石橋俊
    • Organizer
      第39回内分泌代謝研究会
    • Place of Presentation
      東京UDXカンファランス(東京)
    • Year and Date
      2011-12-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 原発性アルドステロン症・サブクリニカルCushing症候群を合併した家族性副甲状腺機能亢進症の一例2011

    • Author(s)
      安藤明彦, 他
    • Organizer
      第39回内分泌代謝研究会
    • Place of Presentation
      東京都・UDXカンファランス
    • Year and Date
      2011-12-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Down-regulated expression of p18INK4C in pituitary adenomas2010

    • Author(s)
      Katsuhiko Yoshimoto, Md. Golam Hossain, Takeo Iwata, Noriko Mizusawa, Schadan Wan Nazatul Shima, Toru Okutsu, Kyoko Ishimoto, Zhi Rong Qian, Toshiaki Sano, Shozo Yamada
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      国立京都国際会館(Kyoto)
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Down-regulated expression of p18INK4C in pituitary adenomas.2010

    • Author(s)
      Katsuhiko Yoshimoto, et al.
    • Organizer
      14^<th> International Congress of Endocrinology
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] MicroRNA Expression Abnormalities in Pituitary Adenomas Are Associated with Distinctive Pathologic Features and May Contribute to Tumorigenesis2010

    • Author(s)
      ZR Qia n, T Tanahashi, K Yoshimoto, S Yamada, S Katsuura, EL Wang, K Rokutan, T Sano
    • Organizer
      99th Annual Meeting of USCAP
    • Place of Presentation
      Marriott Wardman Park Hotel(Washington, DC)
    • Year and Date
      2010-03-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of estrogen receptor beta1in human pituitary adenomas2010

    • Author(s)
      ZR Qian, EL Wang, K Yoshimoto, S Yamada, T Sano
    • Organizer
      99th Annual Meeting of USCAP
    • Place of Presentation
      Marriott Wardman Park Hot el(Washington, DC)
    • Year and Date
      2010-03-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 再発を来した副甲状腺機能亢進症顎腫瘍症候群の一例2010

    • Author(s)
      都島由希子, 宮章博, 舛岡裕雄, 薮田智範, 福島光浩, 友田智哲, 木原実, 井上博之, 東山卓也, 高村勇貴, 伊藤康弘, 小林薫, 吉本勝彦, 廣川満良, 宮内昭
    • Organizer
      第43回日本甲状腺外科学会学術集会
    • Place of Presentation
      倉敷市民会館(倉敷)
    • Related Report
      2011 Final Research Report
  • [Presentation] 下垂体性腺腫のER1、2の発現とDNAのHYPERMETHYLATIONおよび機能分析について2010

    • Author(s)
      銭志栄, 王路, 吉本勝彦, 山田正三, 佐野壽昭
    • Organizer
      第20回日本間脳下垂体腫瘍学会
    • Place of Presentation
      兵庫医科大学平成記念会館(武庫川)
    • Related Report
      2011 Final Research Report
  • [Presentation] 再発を来した副甲状腺機能亢進症顎腫瘍症候群の一例2010

    • Author(s)
      都島由希子, ら
    • Organizer
      第43回日本甲状腺外科学会学術集会
    • Place of Presentation
      倉敷市民会館(倉敷市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] MicroRNA Expression Abnormalities in Pituitary Adenomas are Associated with Dis tinctive Pathologic Features and May Contribute to Tumorigenesis2009

    • Author(s)
      Q ian Zhi Rong, Tanahashi Toshihito, Yoshimoto Katsuhiko, Yamada Shozo, Katsuura Sakurako, Rokutan Kazuhito, Sano Toshiaki
    • Organizer
      第55回日本病理学会秋期特別総会
    • Place of Presentation
      九段会館(東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] MicroRNA expression abnormalities in pituitary adenomas are associated with distinctive pathologic features and may contribute to tumorigenesis2009

    • Author(s)
      Qian Zhi Rong, Tanahashi Toshihito, Yoshimoto Katsuhiko, Yamada Shozo, Katsuura Sakurako, Rokutan Kazuhito, Sano Toshiaki
    • Organizer
      第13回日本内分泌病理学会学術総会
    • Place of Presentation
      山梨大学(甲府)
    • Related Report
      2011 Final Research Report
  • [Presentation] Overexpression of HMGA1 correlates with tumor invasiveness and proliferation in pituitary adenomas2009

    • Author(s)
      王路, 銭志栄, ラハマン・ムスタフイズル, 吉本勝彦, 山田正三, 工藤英治, 佐野壽昭
    • Organizer
      第98回日本病理学会年総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Final Research Report
  • [Presentation] Tumor-specific down-regulation of ER-β1and ER-β2i n Human Pituitary Adenomas2009

    • Author(s)
      銭志栄, 王路, ラハマン・ムスタフイズル, 吉本勝彦, 山田正三, 工藤英治, 佐野壽昭
    • Organizer
      第98回日本病理学会年総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Final Research Report
  • [Presentation] メインシンポジウム3下垂体腺腫:最近の展開2.家族性成長ホルモン産生腺腫2009

    • Author(s)
      吉本勝彦
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      群馬県民会館(前橋)
    • Related Report
      2011 Final Research Report
  • [Book] 下垂体腺腫の分子病理学,下垂体腫瘍のすべて2009

    • Author(s)
      佐野壽昭、吉本勝彦、寺本明、長村義之
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 多発性内分泌腫瘍症1型など,下垂体腫瘍のすべて2009

    • Author(s)
      吉本勝彦、寺本明、長村義之
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.tokushima-u.ac.jp/yakuri/index.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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