Analysis of monocytes involved in joint destruction and joint repair in rheumatoid arthritis
| Project/Area Number |
21591270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Keio University |
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Principal Investigator |
SETA Noriyuki 慶應義塾大学, 医学部, 助教 (40338372)
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| Co-Investigator(Kenkyū-buntansha) |
KUWANA Masataka 慶應義塾大学, 医学部, 准教授 (50245479)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 末梢血単球 / 関節リウマチ / 多分化能 / リウマチ学 / 免疫学 |
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| Research Abstract |
Circulating CD14^+monocytes in rheumatoid arthritis(RA) patients had been already activated, but the number of circulating CD14^+CXCR4^<high> monocytes(Mos) possibly involved in joint repair in RA decreased compared with that in healthy donors. Moreover, the number of circulating CD14^+CXCR4high Mo in RA patients with high disease activity was lower than that in RA patients with low disease activity. On the other hand, CD14^+CD15^+Mos possibly involved in joint destruction abundantly existed in both iliac bone marrow and peripheral blood of RA patients, although CD14^+CD15^+Mos also existed in peripheral blood of healthy donors. These results indicated that the balance of the number of CD14^+CXCR4^<high> Mo and CD14^+CD15^+Mo is important for development of RA.
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Report
(4 results)
Research Products
(9 results)
