| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We performed cytological and genetic examinations in our study. In cytological analysis, we tried to reveal PTCH molecule in the cells by using in situ immunostaining. However, we could not reveal them maybe due to the low affinity of PTCH antibodies, although we tried to use multiple antibodies made by some companies. In genetic analysis, we revealed many PTCH mutations in Gorlin syndrome patients. In particular, we also could identify tandem repeat in the PTCH gene, resulting in Gorlin syndrome.
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