Morphogenesis and Carcinogenesis regulated by PTCH1 gene
| Project/Area Number |
21591313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ゲノム / 遺伝学 / 遺伝子 / 癌 / 放射線 |
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| Research Abstract |
We performed cytological and genetic examinations in our study. In cytological analysis, we tried to reveal PTCH molecule in the cells by using in situ immunostaining. However, we could not reveal them maybe due to the low affinity of PTCH antibodies, although we tried to use multiple antibodies made by some companies. In genetic analysis, we revealed many PTCH mutations in Gorlin syndrome patients. In particular, we also could identify tandem repeat in the PTCH gene, resulting in Gorlin syndrome.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Zebrafish gene knockdowns imply roles for human YWHAG in infantile spasms and cardiomegaly2010
Author(s)
Komoike Y, Fujii K, Nishimura A, Hiraki Y, Hayashidani M, Shimojima K, Nishizawa T, Higashi K, Yasukawa K, Saitsu H, Miyake N, Mizuguchi T, Matsumoto N, Osawa M, Kohno Y, Higashinakagawa T, Yamamoto T
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Journal Title
Genesis
Volume: 48
Pages: 233-43
Related Report
Peer Reviewed
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