Influence on the mode of infection by the variation of the human parvovirus B19 genome.
| Project/Area Number |
21591393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
YOTO Yuko 札幌医科大学, 医学部, 講師 (10404659)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | パルボウイルス / B19V / ゲノム変異 / 転写 / 伝染性紅斑 |
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| Research Abstract |
There have been no long-term systematic analyses of the molecular epidemiology of human parvovirus B19(B19V). We investigated the variations of nucleotide sequences of B19V strains collected in Sapporo, Japan, from 1980 to 2008. In that period, six outbreaks of erythema infectiosum occurred regularly at 5-year intervals. The B19V strains collected successively, regardless of the outbreak, were analyzed for nucleotide variation in the subgenomic NS1-VP1u junction. The isolated strains can be classified into 10 subgroups. Two patterns of change of endemic strains were observed. One was a dynamic replacement of strains that occurred almost every 10 years, and the other was a gradual change consisting of an accumulation of point mutations
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Occurrence of the African subgroup(la) of BK polyomavirus in younger Japanese children2009
Author(s)
Tanaka K, Hori T, Hatakeyama N, Yamamoto M, Takayama R, Yoto Y, Suzuki N, Hayashi T, Ikeda Y, Ikeda H, Ishida T, Tsutsumi H
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Journal Title
Microbiology and Immunology
Volume: Vol.53
Pages: 319-322
NAID
Related Report
Peer Reviewed
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