The efficacy of cannabinoids to the various keratoderma.
| Project/Area Number |
21591462
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
|
|---|
| Research Institution | University of the Ryukyus (2010-2011)
Kyoto University (2009) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | ダリエー病 / ヘイリー・ヘイリー病 / ハプロインサフィシエンシー / カンナビノイド / バニロイド / SERCA2 / 転写 / 創薬 / 優性遺伝 / 尋常性乾癬 / 細胞内カルシウム |
|---|
| Research Abstract |
We showed that the strong induction of SERCA2 expression in the epidermal keratinocytes after the treatments with cannabinoid and vanilloid agonists are direct effects through CB2 and TRPV3/4 receptor, respectively. Also the external application on the Darier's and psoriatic model mouse as a representative of hereditary and inflammatory keratosis, we found that especially the cannabinoids brought about the significant pathological effects which include the a recovery of a stratum granulosum, while vanniloid did not bring such strong impact. I believe that the cannabinoids agonist can be a good candidate of the future therapeutic drug against the hyperkeratotic skin diseases.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] A novel potent tumour promoter aberrantly overexpressed in most human cancers2011
Author(s)
Atsushi Takahashi, Hisashi Tokita, Kenzo Takahashi, Tomoharu Takeoka, Kosho Murayama, Daihachiro Tomotsune, Miki Ohira, Akihiro Iwamatsu, Kazuaki Ohara, Kazufumi Yazaki, Tadayuki Koda
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Journal Title
Akira Nakagawara & Kenzaburo Tani Scientific Reports
Volume: 1
Pages: 1-12
Related Report
Peer Reviewed
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[Journal Article] Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo2010
Author(s)
Kioka N, Ito T, Yamashita H, Uekawa N, Umemoto T, Motoyoshi S, Imai H, Takahashi K, Watanabe H, Yamada M, Ueda K.
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Journal Title
Exp Cell Res
Volume: 316(10)
Pages: 1728-1738
Related Report
Peer Reviewed
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