| Project/Area Number |
21591468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagasaki University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
SATO Shinichi 東京大学, 医学部附属病院, 教授 (20215792)
BAE Sangjae 長崎大学, 病院, 医員 (90325647)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アトピー性皮膚炎 / 神経ペプチド / サブスタンスP / neutral endopeptidase |
|---|
| Research Abstract |
Substance P is released from the sensory nerve of the skin, and it is known that substance P induce the inflammation of the skin. In the patient with the atopic dermatitis, when blood substance P was measured, substance P decreased by the standard treatment, and the m-RNA expression of degrading enzyme of substance P was enhanced. And, in the mouse which gave the stress, the contact hypersensitivity reaction enhanced, and L-selectin and substance P was indicated in the mechanism of enhanced response by the stress.
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