Measurement of cardiac energy efficiency using PET
| Project/Area Number |
21591551
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University (2010-2011)
University of Fukui (2009) |
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Principal Investigator |
KUDO Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (20330300)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Akira 福井大学, 医学部, 助教 (20334815)
ARAKAWA Kenichirou 福井大学, 医学部, 助教 (80401967)
OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 核医学(PETを含む) / 炭素11標識酢酸 / 心筋エネルギー効率 / ポジトロン断層撮影 / 心筋燃費 / エネルギー消費効率 / 心電図同期収集 |
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| Research Abstract |
Using positron emission tomography(PET), especially C-11 acetate PET, we performed simultaneous measurement of myocardial perfusion, metabolism and cardiac function. We proved that the simultaneous measurement of these three parameters is possible. We can calculate the myocardial energy efficiency using this technique. The measurement of myocardial energy efficiency is useful tool for the evaluation of cardiac pathology such as mitochondrial cardiomyopathy, etc.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Prediction of indocyanine green retention rate at 15 minutes by correlated liver function parameters before hepatectomy2011
Author(s)
Nanashima A, Abo T, Tobinaga S, Nonaka T, Fukuoka H, Hidaka S, Takeshita H, Sawai T, Yasutake T, Nagayasu T, Kudo T
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Journal Title
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Relationship of hepatic functional parameters with changes of functional liver volume using technetium-99m galactosyl serum albumin scintigraphy in patients undergoing preoperative portal vein embolization : a follow-up report2010
Author(s)
Nanashima A, Tobinaga S, Abo T, Sumida Y, Araki M, Hayashi H, Sakamoto I, Kudo T, Takashita H, Hidaka S, Sawai T, Hatano K, Nagayasu T
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Journal Title
J Surg Res
Volume: 164
Pages: 235-242
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Abnormal myocardial energy-production state in mitochondrial cardiomyopathy and acute response to L-arginine infusion. C-11 acetate kinetics revealed by positron emission tomography2010
Author(s)
Arakawa K, Kudo T, Ikawa M, Morikawa N, Kawai Y, Sahashi K, Lee JD, Kuriyama M, Miyamori I, Okazawa H, Yoneda M
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Journal Title
Circ J
Volume: 74
Pages: 2702-2711
NAID
Related Report
Peer Reviewed
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[Journal Article] Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia : the possible function in tumor acetyl-CoA/ acetate metabolism2009
Author(s)
Yoshii Y, Furukawa T, Yoshii H, Mori T, Kiyono Y, Waki A, Kobayashi M, Tsujikawa T, Kudo T, Okazawa H, Yonekura Y, Fujibayashi Y
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Journal Title
Cancer Sci
Volume: 100
Pages: 821-827
NAID
Related Report
Peer Reviewed
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