| Project/Area Number |
21591563
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Yoshiharu 神戸大学, 医学研究科, 特命准教授 (30324924)
TAKENAKA Daisuke 神戸大学, 医学研究科, 准教授 (60258233)
MAEDA Tetsuo 神戸大学, 医学研究科, 特命講師 (00457095)
MATSUMOTO Sumiaki 神戸大学, 医学研究科, 特命講師 (60397833)
SUGIMURA Kazuro 神戸大学, 医学研究科, 教授 (00136384)
村瀬 研也 大阪大学, 医学系研究科, 教授 (50157773)
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| Co-Investigator(Renkei-kenkyūsha) |
MURASE Kenya 大阪大学, 医学研究科, 教授 (50157773)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 領域検出器型CT / 上腹部 / 臓器血流・機能測定 / 臓器血流測定ソフトウエア / 低X線量CT撮影 / 形態・機能融合診断法 |
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| Research Abstract |
We evaluated newly-developed Area-Detector CT in functional and morphological assessments of the upper abdominal organ function and diseases. Area-Detector CT was superior to conventional CT in assessment of fine abdominal vessels. We developed CT scanning protocol and injection protocol of contrast medium for abdominal functional(perfusion) CT, correction software for respiratory misregistrations, and software for perfusion analysis with three different analytic methods. Our results showed irradiation during perfusion CT can be reduced to 1/3 and volume and injection rate of contrast medium can be reduced to 1/3 of those in the conventional methods and respiratory misregistrations less than 3 cm can be satisfactorily corrected. Effects of cardiac function were found and it needs to be compensated. In patients with abdominal diseases, we found new findings such as interactions in blood perfusion among the organs and useful perfusion parameters for diagnosis for malignant tumors. It was also found that perfusion CT is useful for assessment of tumor responses after radiotherapy and anticancer agents as well as residual organ function. The results of this study suggest functional and morphological integrated CT using Area-Detector CT can be superior to those of conventional morphological CT in assessments of the upper abdominal organ function and diseases.
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