MRI位相差情報を用いた無侵襲脳血流定量計測法の開発と臨床応用

• Project/Area Number: 21591575
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: 工藤 與亮 Iwate Medical University, 医学部, 講師 (10374232)
• Co-Investigator(Kenkyū-buntansha): 佐々木 真理 岩手医科大学, 医学部, 教授 (80205864) ; 小笠原 邦昭 岩手医科大学, 医学部, 教授 (00305989) ; 寺江 聡 北海道大学, 大学病院, 准教授 (40240634)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 核磁気共鳴画像 / 脳血流 / 位相画像

Research Abstract

本研究の目的は超高磁場MRI装置による位相画像を用いて、非侵襲的で定量的な脳脊髄血流解析法を開発・臨床応用することである。
既存の複数の3T-MRI装置(GE社、Philips社)を用いた磁化率強調画像の位相画像から酸素飽和度を算出するプログラムを作成し、酸素飽和度の定量値算出及び脳血流変化のマップ化を行った。さらに、酸素飽和度から酸素摂取率(OEF)を算出するプログラムを作成し、呼吸負荷や薬物負荷によりOEFが有意に変化することが確認された。これらの研究成果は国際学会での発表を行い、論文投稿中である。また、内頚動脈狭窄患者でも脳の位相画像を撮像し、安静時でもOEFの上昇が観察されたが、さらにOEFマップ作成のアルゴリズム改良を行っている。今までは2回のMRI撮像を行って位相変化から酸素飽和度やOEFの変化率を算出できていたが、それを1回のMRI撮像で絶対値として値を算出できるようにプログラム・アルゴリズムを改変中である。患者群ではDiamox負荷での経時的変化の撮像も行っており、PETでのOEFマップとの比較や、MRIのASL法による脳血流マップとの比較を行っている。
また、同時に脳血流解析の基礎的検討として数値ファントムを開発し、解析プログラムの精度検証を行っているが、市販ソフトウェアでの解析結果がまとまったので論文作成中である。さらに、各市販ソフトウェアメーカへの結果のフィードバックも行っている。

Research Products

• [Journal Article] Non-Invasive Measurement of Oxygen Saturation in the Spinal vein using SWI : Quantitative Evaluation under Conditions of Physiological and Caffeine Load (2011)
  • Author(s): Fujima N, Kudo K, Terae S, Ishizaka K, Yazu R, Zaitsu Y, Tha KK, Yoshida K, Tsukahara A, Haacke EM, Sasaki M, Shirato H
  • Journal Title: Neuroimage Volume: 54 Pages: 344-349
  • Peer Reviewed
• [Journal Article] Susceptibility of Tmax to Tracer Delay on Perfusion Analysis : Quantitative Evaluation of Various Deconvolution Algorithms Using Digital Phantoms (2010)
  • Author(s): Kudo K, Sasaki M, Ostergaard L, Christensen S, Uwano I, Suzuki M, Ogasawara K, Shirato H, Ogawa A
  • Journal Title: JCBFM Volume: (In press)
  • Peer Reviewed
• [Journal Article] Susceptibility-Weighted Imaging of Cerebral Fat Embolism (2010)
  • Author(s): Zaitsu Y, Terae S, Kudo K, Tha KK, Hayakawa M, Fujima N, Yoshida D, Tsukahara A, Shirato H
  • Journal Title: J Comput Assist Tomogr Volume: 34 Pages: 107-112
  • Peer Reviewed
• [Journal Article] Brain Temperature Measured by Proton Magnetic Resonance Spectroscopy Predicts Cerebral Hyperperfusion after Carotid Endarterectomy (2010)
  • Author(s): Murakamki T, Ogasawara K, Yoshioka Y, Ishigaki D, Sasaki M, Kudo K, Aso K, Nishimoto H, Kobayashi M, Yoshida K, Ogawa A
  • Journal Title: Radiology Volume: 256 Pages: 924-931
  • Peer Reviewed
• [Journal Article] Prediction of infarct volume and neurologic outcome by using automated multiparametric perfusion-weighted magnetic resonance imaging in a primate model of permanent middle cerebral artery occlusion (2010)
  • Author(s): Sasaki M, Kudo K, Honjo K, Hu JQ, Wang HB, Shintaku K
  • Journal Title: JCBFM Volume: (In press)
  • Peer Reviewed
• [Journal Article] High-resolution diffusion tensor imaging for the detection of diffusion a bnormalities in the trigeminal nerves of patients with trigeminal neuralgia caused by neurovascular compression. (2010)
  • Author(s): Fujiwara S, Sasaki M, Wada T, Kudo K, Hirooka R, Ishigaki D, Nishikawa Y, Ono A, Yamaguchi M, Ogasawara K
  • Journal Title: J Neuroimaging Volume: (In press)
  • Peer Reviewed
• [Journal Article] Susceptibility-Weighted Imaging and Magnetic Resonance Angiography during Migraine Attack : A Case Report (2010)
  • Author(s): Shimoda Y, Kudo K, Kuroda S, Zaitsu Y, Fujima N, Terae S, Sasaki M, Houkin K
  • Journal Title: Magnetic Resonance in Medical Science Volume: (In press)
  • NAID: 10029698098
  • Peer Reviewed
• [Journal Article] Differences in CT Perfusion Maps Generated by Different Commercially Available Software : Analysis Using Identical Source Data of Acute Stroke Patients (2010)
  • Author(s): Kudo K, Sasaki M, Yamada K, Momoshima S, Utsunomiya H, Shirato H, Ogasawara K
  • Journal Title: Radiology 254 Pages: 200-209
  • Peer Reviewed
• [Journal Article] Evaluation of Change in Venous Oxygenation by Susceptibility-Weighted Imaging in Patients with Spinal Arterio-Venous Malformations after Treatment (2010)
  • Author(s): Fujima N, Kudo K, Terae S, Hida K, Ishizaka K, Zaitsu Y, Asano T, Yoshida D, Tha KK, Sasaki M, Shirato H
  • Journal Title: Radiology (In press)
  • Peer Reviewed
• [Journal Article] Visual discrimination among patients with depression and schizophrenia and healthy individuals using semiquantitative color-coded fast spin-echo T1-weighted magnetic resonance imaging (2010)
  • Author(s): Sasaki M, Shibata E, Ohtsuka K, Endoh J, Kudo K, Narumi S, Sakai A
  • Journal Title: Neuroradiology 52 Pages: 83-89
  • Peer Reviewed
• [Journal Article] In vivo topographic illustration of microstructural white matter abnorm ahties of multiple system atrophy by diffusion tensor imaging (2010)
  • Author(s): Tha KK, Terae S, Yabe I, Miyamoto T, Soma H, Zaitsu Y, Fujima N, Kudo K, Sasaki H, Shirato H
  • Journal Title: Radiology (In press)
  • Peer Reviewed
• [Journal Article] Difference in the Tracer Delay-Induced Effect among Deconvolution Algorithms in CT Perfusion Analysis : Quantitative Evaluation by using Digital Phantoms (2009)
  • Author(s): Kudo K, Sasaki M, Ogasawara K, Terae S, Ehara S, Shirato H
  • Journal Title: Radiology 251 Pages: 241-249
  • Peer Reviewed
• [Journal Article] Detectability of Normal Spinal Veins by Using Susceptibility Weighted Imaging (2009)
  • Author(s): Ishizaka K, Kudo K, Fujima N, Zaitsu Y, Yazu R, Tha KK, Terae S, Sasaki M, Shirato H
  • Journal Title: J Magn Reson Imaging 31 Pages: 32-38
  • Peer Reviewed
• [Journal Article] Susceptibility-weighted magnetic resonance imaging detects impaired cerebral hemodynamics in the superior sagittal sinus thrombosis-case report (2009)
  • Author(s): Kawabori M, Kuroda S, Kudo K, Terae S, Kaneda M, Nakayama N, Iwasaki Y
  • Journal Title: Neurol Med Chir (Tokyo) 49 Pages: 248-251
  • NAID: 10025947920
  • Peer Reviewed
• [Journal Article] Differential diagnosis of hyperintense cerebrospinal fluid on fluid-attenu ated inversion recovery images of the brain. Part I : pathological conditions. (2009)
  • Author(s): Tha KK, Terae S, Kudo K, Miyasaka K.
  • Journal Title: Br J Radiol 82 Pages: 426-434
  • Peer Reviewed
• [Journal Article] Differential diagnosis of hyperintense cerebrospinal fluid on fluid-attenuated inversion recovery images of the brain. Part II : non-pathological conditions. (2009)
  • Author(s): Tha KK, Terae S, Kudo K, Miyasaka K
  • Journal Title: Br J Radiol 82 Pages: 610-614
  • Peer Reviewed
• [Journal Article] Detection of changes in cerebrospinal fluid space in idiopathic normal pressure hydrocephalus using voxel-based morphometry (2009)
  • Author(s): Yamashita F, Sasaki M, Takahashi S, Matsuda H, Kudo K, Narumi S, Terayama Y, Asada T
  • Journal Title: Neuroradiology 22(Epub)
  • Peer Reviewed
• [Journal Article] Prospective study on the mismatch concept in acute stroke patients within the first 24h after symptom onset-1000Plus study (2009)
  • Author(s): Hotter B, Pittl S, Ebinger M, Oepen G, Jegzentis K, Kudo K, Rozanski M, Schmidt WU, Brunecker P, Xu C, Martus P, Endres M ; Jungehulsing GJ, Villringer A, Fiebach JB
  • Journal Title: BMC Neurology 9 Pages: 60-60
  • Peer Reviewed
• [Presentation] ACCURACY AND RELIABILITY OF POST-PROCESSING SOFTWARE FOR CT PERFUSION : QUANTITATIVE ANALYSIS BY DIGITAL PHANTOM (2010)
  • Author(s): Kudo K, Christensen S, Sasaki M, Uwano I, Sasaki T, Ogasawara K, Ostergaard L
  • Organizer: World Stroke Congress
  • Place of Presentation: Seoul
  • Year and Date: 2010-10-13
• [Presentation] Neuro Applications of Echelon 1.5T MRI (2010)
  • Author(s): Kudo K
  • Organizer: MRI Seminar in Singapore
  • Place of Presentation: Singapore
  • Year and Date: 2010-10-09
• [Presentation] 中枢神経:CT/MRIのピットフォール 脳血管障害 (2010)
  • Author(s): 工藤與亮
  • Organizer: 日本放射線科専門医会・医会ミッドサマーセミナー
  • Place of Presentation: 神戸
  • Year and Date: 2010-07-24
• [Presentation] Accuracy and Reliability of Post-Processing Software for DSC MR Perfusion : Quantitative Analysis by Digital Phantom Data (2010)
  • Author(s): Kudo K, Christensen S, Sasaki M, Straka M, Fujiwara S, Ishizaka K, Zaitsu Y, Fujima N, Terae S, Ogasawara K, Ostergaard L
  • Organizer: ISMRM
  • Place of Presentation: Stockholm
  • Year and Date: 2010-05-01
• [Presentation] Improved Quantification of cerebral blood flow change using phase information of SWI, corrected by arterial oxygen saturation (2010)
  • Author(s): Zaitsu Y, Kudo K, Yazu R, Ishizaka K, Fujima N, Terae S, Sasaki M, Shirato H
  • Organizer: ISMRM
  • Place of Presentation: Stockholm
  • Year and Date: 2010-05-01
• [Presentation] 脳卒中の日常臨床における脳循環代謝画像:有用性と限界「CT灌流画像」 (2010)
  • Author(s): 工藤與亮
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-16
• [Presentation] デジタルファントムを用いたCT灌流画像解析ソフトの精度検証 (2010)
  • Author(s): 工藤與亮、Soren Christensen、佐々木真理、笹木工、藤原俊朗、小笠原邦昭、Leif Ostergaard
  • Organizer: 日本神経放射線学会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-12
• [Presentation] MR灌流画像解析の標準化に向けたデジタルファントムの作成と応用 (2009)
  • Author(s): 工藤與亮、Soren Christensen、佐々木真理、藤原俊朗、Leif Ostergaard
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] SWI of the Spinal Veins (2009)
  • Author(s): Kudo K
  • Organizer: ISMRM (International Society for Magnetic Reso nance in Medicine)
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2009-04-18