Development of novel production method of high purity lutetium-177 for advanced cancer therapy
| Project/Area Number |
21591586
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Japan Atomic Energy Agency |
|---|
Principal Investigator |
WATANABE Satoshi 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究副主幹 (40354964)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | ルテチウム-177 / 分離精製法 / イミノ二酢酸キレート樹脂 / Lu-177 / 分離・精製法 / 高純度 / ルテチム-177 |
|---|
| Research Abstract |
Lutetium-177 is considered to have potential for application in radionuclide therapy, because it emits b-particles suitable to penetrate small tumors. In addition, real time imaging of biodistribution can be done by using the ^<177>Lu, because the energy of g-rays emitted from ^<177>Lu is particularly suitable for imaging by single photon emission computed tomography. In the field of radioimmunotherapy using labeled monoclonal antibodies, to enhance the effect of therapy, no-carrier-added ^<177>Lu produced in the ^<176>Yb(n, g) ^<177>Yb → ^<177>Lu process are desired. In this production, separation of ^<177>Lu from Yb target is required. Therefore, in the present paper, basic study of separation between Lu and Yb by using iminodiacetic acid chelating resin is investigated. It was found that the best separation between Lu and Yb was achieved by using 0.013 M HNO_3 for the eluent and the column of 4.6 mmφｘ450 mm size.
|
Report
(4 results)
Research Products
(1 results)
