| Project/Area Number |
21591643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kochi University |
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Principal Investigator |
OKADA Hironobu 高知大学, 教育研究部・医療学系, 助教 (10444770)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Masaki 高知大学, 教育研究部・医療学系, 助教 (20437718)
YAMAGUCHI Tokio 東京医科歯科大学, 難治疾患研究所, 准教授 (30134745)
MAEDA Hironori 高知大学, 教育研究部・医療学系, 准教授 (20335946)
SASAGURI Shiro 高知大学, 教育研究部・医療学系, 教授 (60196186)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 外科総論 / 酸化ストレス / 全身性炎症反応症候群 / SIRS / ビリルビン / 酸化ビリルビン / バイオピリン / 活性酸素 / 窒素ラジカル / 抗酸化治療 |
|---|
| Research Abstract |
Systemic Inflammatory Response Syndrome might influence organs by oxidative stress. We assessed the oxidative bilirubin, named biopyrrins, in organs and urine. The biopyrrins were synthesized in organs, such as lung, liver and kidney. Furthermore, urinary biopyrrins concentration was elevated biphasically under SIRS.
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