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Association between risk and prognostic values of breast cancer and the wild-type allele of human ABC transporter ABCC11.

Research Project

Project/Area Number 21591673
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionYokohama City University

Principal Investigator

CHISHIMA Takashi  横浜市立大学, 附属病院, 准教授 (70438141)

Co-Investigator(Kenkyū-buntansha) ISHIKAWA Takashi  横浜市立大学, 市民総合医療センター, 准教授 (80275049)
Co-Investigator(Renkei-kenkyūsha) HAYASHIZAKI Yoshihide  独立行政法人理化学研究所, オミックス基盤研究領域, 領域長 (70192705)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords乳癌 / 罹患率 / 個別化検診 / ABCC11遺伝子 / 遺伝子多型 / 耳垢タイプ / 耳垢型 / ABCC11 / 薬剤耐性
Research Abstract

It was found that earwax type is determined by a single nucleotide polymorphism in ABCC11.The present study examined the association between the frequency rate of breast cancer and the polymorphism(G allele) of ABCC11.The frequency of the G allele in breast cancer patients was higher than that in healthy controls in Japan. The odds ratio for the genotypes to develop breast cancer was estimated to be 1.63(p-value=0.026), suggesting that the G allele in ABCC11 is associated with breast cancer risk. This study showed that Japanese women with wet earwax have a higher relative risk of developing breast cancer than those with dry earwax.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC112010

    • Author(s)
      Ota I, Chishima T, Hayashizaki Y, Ishikawa T, et al
    • Journal Title

      Anticancer Research

      Volume: 12巻 Pages: 5189-94

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11.2010

    • Author(s)
      Ota I, Chishima T, et al
    • Journal Title

      Anticancer Res.

      Volume: 30 Pages: 5189-5194

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Predictors of anti-cancer agents in each subtype of breast cancer2011

    • Author(s)
      Ishikawa T, Chishima T, et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 精査機関で良性経過観察中に発見された中間期乳癌の臨床病理学的検討2011

    • Author(s)
      木村万里子、千島隆司, 他
    • Organizer
      第19回日本乳癌学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 直接変換方式FPD搭載マンモグラフィ装置におけるWターゲットの有用性の検討2011

    • Author(s)
      伊藤紀子、千島隆司, 他
    • Organizer
      第19回日本乳癌学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] HER2陰性乳癌の更なる個別化をめざして2011

    • Author(s)
      石川孝、千島隆司, 他
    • Organizer
      第19回日本乳癌学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] ABCC11遺伝子多型と乳癌罹患のリスク、予後規定因子の検討2010

    • Author(s)
      太田郁子、千島隆司、石川孝他
    • Organizer
      第20回日本乳癌検診学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ABCC11遺伝子多型解析による乳癌罹患のリスクと予後規定因子の検討2009

    • Author(s)
      太田郁子、千島隆司、石川孝他
    • Organizer
      第17回日本乳癌学会総会
    • Place of Presentation
      ホテル日航東京
    • Year and Date
      2009-07-03
    • Related Report
      2011 Final Research Report
  • [Presentation] ABCC11遺伝子多型解析による乳癌罹患のリスクと予後規定因子の検討2009

    • Author(s)
      太田郁子, 千島隆司, 他
    • Organizer
      第17回日本乳癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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