| Project/Area Number |
21591676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWAYA Takeshi 岩手医科大学, 医学部, 助教 (70405801)
WAKABAYASHI Go 岩手医科大学, 医学部, 教授 (50175064)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 薬剤耐性 / 胃癌 / シスプラチン / バイオチップ / 分子ネットワーク / プロテオミクス / 抗癌剤 / 細胞集団 / 癌幹細胞 / ストレス反応 / シグナル伝達 / 蛋白アレイ / 分子間作用 |
|---|
| Research Abstract |
It is important to clarify the drug-resistant mechanism of cancer cells in the context of cancer chemotherapy. Advances on adjuvant chemotherapy after oncologically curative operation have prolonged the long-term disease-free and overall survival rates. However, approximately 30-40% cases still experience recurrence despite of adjuvant chemotherapy. In the present study, we established a drug-resistant gastric cancer cell line to clarify the drug-resistant mechanism. Pathways for DNA damage response were found disrupted in the resistant cell line. These results suggest that the resistant cell is unable to control cell cycle or apoptosis, which results in continuous proliferation.
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