Application of endoscopic cell sheet transplantation for colorectal
| Project/Area Number |
21591735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
OHKI Takeshi 東京女子医科大学, 医学部, 助教 (90307562)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 移植 / 再生医療 / 細胞シート工学 / 大腸癌 / 内視鏡外科 / 移植・再生医療 |
|---|
| Research Abstract |
Based on clinical research of regenerative medical treatments using human oral mucosal epithelial cell sheets to prevent constriction after esophageal ESD, I conducted basic experiments on miniature pigs whereby cell sheets were applied to ulcerations caused by colorectal ESD. I conducted colorectal ESD on a miniature pig, followed by engraftment using fibroblast cell sheets. However, the isolated cells of the pig grew unstably. Therefore I decided to use oral mucosal cell sheets instead. The results of our study show that colorectal cell sheet transplantation is a good short-term treatment. It is possible that perforations can be repaired with cell sheets, decreasing the risk of complications. However, this possibility requires further study.
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Report
(4 results)
Research Products
(44 results)
