Cancer specific delivery of magnetic nanoparticles.

• Project/Area Number: 21591743
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Tsukuba
• Principal Investigator: ODA Tatsuya University of Tsukuba, 大学院・人間総合科学研究科, 講師 (20282353)
• Co-Investigator(Kenkyū-buntansha): MURATA Soichiro 筑波大学, 大学院・人間総合科学研究科, 講師 (40436275)
• Co-Investigator(Renkei-kenkyūsha): KITA Eiji 筑波大学, 大学院・数理物質科学研究科, 教授 (80134203) ; KANAMORI Toshiyuki 独立行政法人産業技術総合研究所, バイオニクス研究センターバイオナノマテリアルチーム, 主任研究員 (50356797)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肝臓外科学 / がん / 磁性体 / ナノ粒子 / 電磁誘導加熱

Research Abstract

For clinical application of induction heating cancer therapy, specific accumulation of magnetic nanoparticles to cancer tissue is a indispensable fundamental technique. Conventional approach, viz. tumor specific antibody conjugate nanoparticle, confer only 0.2mg/g tumor accumulation. Intending to precipitate more particles to tumor, we have tried to innovate multiple step administration of biotinaized and avidinaized magnetic nanoparticles alternateively. This approach, however, failed to accumulate nanoparticles to tumor, due to non-specific trap by Kpper cells in liver. When we tried alternative approach, i.e. decoration of nonparticle surface with original unique PEG, 0.58mg/g tumor accumulation have achieved.

Research Products

• [Journal Article] Ferromagnetic nanopart icles for magnetic hyperthermia an d thermoablation therapy (2010)
  • Author(s): Kita E, Oda T, Kayano T, Sato S, Minagawa M, Yanagihara H, Kishimoto M, Mitsumata C, Hashimoto S, Yamada K, Ohokohchi N
  • Journal Title: Journal of Physics D. 43 Pages: 474011-474011
  • Peer Reviewed
• [Journal Article] Heating characteristics of ferr omagnetic iron oxide nano-particles formagnetic hyperthermia. (2010)
  • Author(s): Kita E, Kayano T, Minagawa M, Yanagihara H, Kishimoto M, Hashimoto S, Yamada K, Oda T, Ohkohchi N, Takagi T, Kanamori T, Ikehata Y, Nagano I
  • Journal Title: Journal of Applied Physics. 107
  • Peer Reviewed
• [Journal Article] Minimally required heat doses for various tumour sizes in induction heating cancer therapy determined by computer simulation using experimental data. (2010)
  • Author(s): Yamada K, Oda T, Hashimoto S, Enomoto T, Ohkohchi N, Ikeda H, Yanagihara H, Kishimoto M,Kita E, Tasaki A, Satake M, Ikehata Y, Nagae H, Nagano I, Takagi T, Kanamori T
  • Journal Title: International Journal of Hyperr hermia. 26(5) Pages: 465-474
  • Peer Reviewed
• [Journal Article] Ferromagnetic nanoparticles for magnetic hyperthermia and thermoablation therapy. (2010)
  • Author(s): Kita E, Oda T, Kayano T, Sato S, Minagawa M, Yanagihara H, Kishimoto M, Mitsumata C, Hashimoto S, Yamada K, Ohokohchi N.
  • Journal Title: Journal of Physics D Volume: 43 Pages: 474011-474011
  • Peer Reviewed
• [Journal Article] Heating characteristics of ferromagnetic iron oxide nano-particles formagnetic hyperthermia. (2010)
  • Author(s): Kita E, Kayano T, Minagawa M, Yanagihara H, Kishimoto M, Hashimoto S, Yamada K, Oda T, Ohkohchi N, Takagi T, Kanamori T, Ikehata Y, Nagano I.
  • Journal Title: Journal of Applied Physics Volume: 107
  • Peer Reviewed
• [Journal Article] Minimally required heat doses for various tumour sizes in induction heating cancer therapy determined by computer simulation using experimental data. (2010)
  • Author(s): Yamada K, Oda T, Hashimoto S, Enomoto T, Ohkohchi N, Ikeda H, Yanagihara H, Kishimoto M, Kita E, Tasaki A, Satake M, Ikehata Y, Nagae H, Nagano I, Takagi T, Kanamori T.
  • Journal Title: International Journal of Hyperrhermia Volume: 26(5) Pages: 465-474
  • Peer Reviewed
• [Journal Article] Objective requirement for needle-less induction heating cancer therapy from the viewpoint of physics (2010)
  • Author(s): K.Yamada, T.Oda, S.Hashimoto, T.Enomoto, N.Ohkohchi, H.Ikeda, H.Yanagihara, M.Kishimoto, E.Kita, A.Tasaki, M.Satake, Y.Ikehata, H.Nagae, I.Nagano, T.Tagagi, T.Kanamori.
  • Journal Title: Hyperthermia (in press)(印刷中)
  • Peer Reviewed
• [Journal Article] Heating characteristics of ferromagnetic iron oxide nano-particles formagnetic hyperthermia (2010)
  • Author(s): E.Kita, T.Kayano, M.Minagawa, H.Yanagihara, M.Kishimoto, S.Hashimoto, K.Yamada, T.Oda, N.Ohkohchi, T.Takagi, T.Kanamori, Y.Ikehata, I.Nagano
  • Journal Title: Journal of Applied Physics (in press)(印刷中)
  • Peer Reviewed
• [Journal Article] Preoperative 3D volumetric analysis for liver congestion applied in a patient with hilar cholangiocarcinoma. (2010)
  • Author(s): Takahashi K, Sasaki R, Kondo T, Oda T, Murata S, Ohkohchi N.
  • Journal Title: Langenbecks Arch Surg (in press)(印刷中)
  • Peer Reviewed
• [Journal Article] The measurement of small magnetic signals from magnetic nanoparticles attached to the cell surface and surrounding living cells using a general-purpose SQUID magnetometer. (2009)
  • Author(s): Hashimoto S, Oda T, Yamada K, Takagi M, Enomoto T, Ohkohchi N, Takagi T, Kanamori T, Ikeda H, Yanagihara H, Kita E, Tasaki A
  • Journal Title: Phys Med Biol. 54 Pages: 2571-83
  • Peer Reviewed
• [Journal Article] Hysteresis Power-Loss Heating of Ferromagnetic Nanoparticles Designed for Magnetic Thermoablation. (2009)
  • Author(s): Kita E., Yanagihara H., Hashimoto S., Yamada K., Oda T.. Kishimoto M., Tasaki A.
  • Journal Title: Magnetics, IEEE Transactions on 44(11) Pages: 4452-4455
  • Peer Reviewed
• [Journal Article] Hysteresis Power-Loss Heating of Ferromagnetic Nanoparticles Designed for Magnetic Thermoablation. Magnetics (2009)
  • Author(s): Kita, E., Yanagihara, H., Hashimoto, S., Yamada, K., Oda, T., Kishimoto, M., Tasaki A.
  • Journal Title: IEEE Transactions on 44(11) Pages: 4452-4455
  • Peer Reviewed
• [Journal Article] The measurement of small magnetic signals from magnetic nanoparticles attached to the cell surface and surrounding living cells using a general-purpose SQUID magnetometer. (2009)
  • Author(s): Hashimoto S, Oda T, Yamada K, Takagi M, Enomoto T, Ohkohchi N, Takagi T, Kanamori T, Ikeda H, Yanagihara H, Kita.E, Tasaki A.
  • Journal Title: Phys Med Biol 54 Pages: 2571-2583
  • Peer Reviewed
• [Presentation] Enhanced delivery of chemotherapeutic nanoparticles by depleting host Kupffercells. (2011)
  • Author(s): Ohara Y, Oda T, Yamada K, Hashimoto S, Akashi Y, Kobayashi A, Fukunaga K, Sasaki R, Ohkkohchi N
  • Organizer: American Association of Cancer Research special conference "Nano in Cancer"
  • Place of Presentation: Miami, FL, USA
• [Presentation] Enhanced delivery of chemotherapeutic nanoparticles by depleting hostKupffer cells (2011)
  • Author(s): Ohara Y, Oda T, Yamada K, Hashimoto S, Akashi Y, Kobayashi A, Fukunaga K, Sasaki R, Ohkkohchi N
  • Organizer: American Association of Cancer Research special conference "Nano in Cancer"
  • Place of Presentation: Miami, FL, USA
• [Presentation] マクロファージ除去によりナノ粒子化抗癌剤の腫瘍集積を増大させる (2010)
  • Author(s): 大原佑介、小田竜也、山田圭一、橋本真治、明石義正、村田聡一郎、小林昭彦、福永潔、佐々木亮孝、大河内信弘
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 多発性肝転移を電磁誘導加温にて焼灼する条件とそのための新規磁性粒子の開発 (2010)
  • Author(s): 山田圭一、小田竜也、大原佑介、橋本真治、小林昭彦、村田聡一郎、福永潔、佐々木亮孝、大河内信弘
  • Organizer: 第22回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-26
• [Presentation] Development of thermo-ablation cancer therapy using new ferromagnetic nanoparticles and alternative magnetic field device : Superpara magnetic particles versus New ferromagnetic nanoparticles. (2009)
  • Author(s): S Hashimoto, T Oda, K Yamada, Y Ohara, N Ohkohchi, H Yanagihara, M Kishimoto, E Kita, T Kanamori, Y Ikehata, H Nagae, I Nagano
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜
• [Presentation] 強磁性ナノ粒子流体における溶媒粘性の影響 (2009)
  • Author(s): 榧野尊 橋本真治 山田圭一小田竜也 佐伯大輔 金森敏幸 柳原英人 岸本幹雄 喜多英治
  • Organizer: 第33回日本磁気学会学術講演会
  • Place of Presentation: 長崎
• [Presentation] 強磁性体ナノ粒子を用いた新規温熱療法の開発へ向けて (2009)
  • Author(s): 橋本真治、小田竜也、山田圭一、大原佑介、大河内信弘、柳原英人、喜多英治、岸本幹雄、長野勇、池畑芳雄
  • Organizer: 第33回日本磁気学会学術講演会
  • Place of Presentation: 長崎
• [Presentation] The physical requirement for induction heating cancer therapy using magnetic nanoparticles. (2009)
  • Author(s): Yamada K, Oda T, Hashimoto S, Takagi M, Ohkohchi N, Ikeda H, Yanagihara H, Kita E, Tasaki A, Takagi T, Kanamori T
  • Organizer: 25th Annual Meeting of the EUROPEAN SOCIE TY for HYPERTHERMIC ONCOLOGY.
  • Place of Presentation: Verona, Italy
• [Presentation] リゾビストにおける電磁誘導焼灼治療と免疫反応を組み合わせた多発がん結切治療の試み (2009)
  • Author(s): 高木美那子,小田竜也,山田圭一,橋本真治,村田聡一郎,大河内信弘
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] The physical requirement for induction heating cancer therapy using magnetic nanoparticles (2009)
  • Author(s): 山田圭一, 小田竜也, 橋本真治, 高木美那子, 大河内信弘, 池畑芳雄, 柳原英人, 喜多英治, Tasaki A, Takagi T, 金森敏幸
  • Organizer: 25th Annual Meeting of the EUROPEAN SOCIETY for HYPERTHERMIC ONCOLOGY
  • Place of Presentation: Verona, Italy
• [Presentation] Development of thermo-ablation cancer therapy using new ferromagnetic nanoparticles and alternative magnetic field device : Superpara magnetic particles versus New ferromagnetic nanoparticles (2009)
  • Author(s): 橋本真治, 小田竜也, 山田圭一, 大原佑介, 大河内信弘, 柳原英人, 岸本幹雄, 喜多英治, 金森敏幸, 池畑芳雄, H Nagae, 長野勇
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜