The abnormality of some genes which repair DNA double strand break in lung cancer of the workers with chromate exposure.
| Project/Area Number |
21591815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KONDO Kazuya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10263815)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIZAWA Hiromitsu 徳島大学, 病院, 講師 (90332816)
NAKAGAWA Yasushi 徳島大学, 病院, 助教 (80380103)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | クロム肺癌 / microsatellite instability / DNA修復 / MRE11遺伝子 / mononucleotide repeat / 扁平上皮癌 / 職業性肺癌 / 肺癌 / クロム酸塩 / マイクロサテライト不安定性 / MRE11 / RAD50 |
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| Research Abstract |
We examined abnormality of the poly(T) region of the DNA repair gene, MRE11 in lung cancers with chromate exposure or without exposure. We performed fragment analysis using capillary DNA sequencer. The deletion of MRE11 gene of chromate lung cancers was significantly higher than that of non-chromate lung cancer(7(25%) versus 1(4%), p=0. 033). In chromate lung cancer, microsatellite instability case had 4(22%) deletion, and microsatellite stable case had 3(30%) deletion.
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Report
(4 results)
Research Products
(5 results)
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[Presentation] クロム酸塩に暴露したヒト肺癌におけるdsDNAの切断を修復するDNA修復遺伝子の異常の検討2011
Author(s)
白石真理子, 近藤和也, 岩佐裕介, 藤田結衣, 大岩由香里, 高井チカ子, 滝沢宏光, 中川靖士, 鳥羽博明, 川上行奎, 梶浦耕一郎, 監崎孝一郎, 先山正二, 丹黒章
Organizer
第52回日本肺癌学会総会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2011-11-03
Related Report
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