Establishment of a Novel Therapeutic Strategy Using Tissue Regeneration for Intractable Spinal Infections.
| Project/Area Number |
21591889
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
ITO Manabu 北海道大学, 大学院・医学研究科, 特任教授 (00271677)
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| Co-Investigator(Kenkyū-buntansha) |
AKAZAWA Toshiyuki 地方独立行政法人北海道立総合研究機構, 産業技術研究本部 工業試験場高分子・セラミックス材料グループ, 研究主幹 (80469692)
HOJYO Yoshihiro 北海道大学, 大学院・医学研究科, 助教 (60451423)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リン酸カルシウム / 超音波処理 / 抗生物質 / 骨形成蛋白質 / 吸着徐放性 / 脊椎感染症 / 整形外科 / 組織誘導再生法 / 組織誘導再生 |
|---|
| Research Abstract |
Commercial porous bioceramics were partially dissolved in saturated acid solutions and calcium phosphate microcrystals were precipitated on the surfaces of bioceramics by the supersonic dissolution -precipitation method. Calcium phosphate ceramics having excellent bio-absorption and osteoinduction were newly produced by controlling adsorption and release characteristics of bone-morphogenetic protein (rhBMP-2). As a surface modification technique of bioceramics, the supersonic treatment technology using commercial parenteral fluids was established and antibiotic (Cefazolin)-adsorption and release characteristics on the ceramics were clarified. Biomimetic composites of apatite and collagen which were suitable for tissue regeneration were synthesized and the good bio-absorption was recognized. Concerning a quantitative evaluation for patients with intractable spinal infections, severity maps of infection sites were created in 8 cases of intractable spinal infections by using FDG-PET CT.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Microstructure and Bio-Absorption Characteristics of Hydroxyapatite Modified by a Partially Supersonic Dissolution-Precipitation Technique2009
Author(s)
T Akazawa, M Murata, M Takahama, D Xianjun, Y Abe, K Nakamura, J Hino, J Tazaki, K Ito, M Ito, et al.
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Journal Title
Archives of BioCeramics Research
Volume: 9巻
Pages: 123-126
Related Report
Peer Reviewed
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