Isoflurane-induced postconditioning is mediated by activation of mitochondrial calcium-activated potassium channels
| Project/Area Number |
21591975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OSHITA Shuzo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60144945)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Katsuya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263841)
TSUTSUMI Yasuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (90523499)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 吸入麻酔薬 / イソフルラン / 心筋保護効果 / Ca依存性Kチャネル / ミトコンド / ミトコンドリア |
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| Research Abstract |
Volatile anesthetics isoflurane have an anesthetic postconditioning effects that induce cardioprotective effects against myocardial ischemia and reperfusion injury. We demonstrated that activation of mitochondrial calcium-activated potassium channels play a pivotal role on these action. Furthermore, we showed that volatile anesthetics induced modulation of mitochondrial protein by O-linked beta-N-acetylglucosamine also have an important for volatile anesthetics induced cardioprotection.
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Report
(4 results)
Research Products
(22 results)
