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Function of a new aquaporin in the brain edema.

Research Project

Project/Area Number 21591983
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagoya City University

Principal Investigator

SOBUE Kazuya  名古屋市立大学, 大学院・医学研究科, 教授 (90264738)

Co-Investigator(Kenkyū-buntansha) ASAI Kiyofumi  名古屋市立大学, 大学院・医学研究科, 教授 (70212462)
SUGIURA Takeshi  名古屋市立大学, 大学院・医学研究科, 講師 (20295611)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords水チャネル / 中枢神経 / 発現調節 / 脳浮腫 / アクアポリン / 水チャンネル / アストロサイト
Research Abstract

The membrane pore proteins, aquaporins(AQPs), facilitate the osmotically driven passage of water and, in some instances, small solutes. AQP4 plays important roles in maintaining brain homeostasis and formation of brain edema. However, little is known about function of AQP9 in brain edema. The expression of AQP9 is regulated by the p38 MAPK pathway. Hypoxia evoked a marked decrease in the expression levels of AQP9 and in astrocytes in vitro subsequent reoxygenation elicited the restoration of the expression of AQP9 to their basal levels. These results suggest that AQP9 may be one of the candidates for inducing the intracranial edema in the CNS after ischemia injury.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] 血液脳関門2012

    • Author(s)
      祖父江和哉、杉浦健之, 他
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 387-390

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras(ERas) signal in neuroblastoma cells2011

    • Author(s)
      Aoyama M, Kataoka H, Kubota E, Tada T, Asai K
    • Journal Title

      Int J Oncol

      Volume: 37 Pages: 1011-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] 神経保護Q&A-神経救急・集中治療的アプローチの実際-神経救急・集中治療の重要性と必要な基礎知識および脳保護・脳蘇生の展望脳障害の病態と血液脳関門2011

    • Author(s)
      祖父江和哉、有馬一, 他
    • Journal Title

      救急・集中治療

      Volume: 23 Pages: 1013-1018

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 水チャネル<アクアポリン>の中枢神経における多様な機能と関連疾患2010

    • Author(s)
      祖父江和哉他
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 38 Pages: 145-50

    • NAID

      10026404857

    • Related Report
      2011 Final Research Report
  • [Journal Article] 水チャネル<アクアポリン>の中枢神経における多様な機能と関連疾患2010

    • Author(s)
      粗父江和哉, ら
    • Journal Title

      録本歯科麻酔学会雑誌

      Volume: 38 Pages: 145-150

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 脳卒中の再生医療に向けて2010

    • Author(s)
      太田晴子, ら
    • Journal Title

      循環器内科

      Volume: 68 Pages: 393-7

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells.2010

    • Author(s)
      Aoyama M, et al.
    • Journal Title

      Int J Oncol

      Volume: 37 Pages: 1011-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of reversion-induced LIM protein(RIL)in the rat central nervous system2009

    • Author(s)
      Iida Y
    • Journal Title

      Acta Histochemica et Cytochemica 42

      Pages: 9-14

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 敗血症におけるastrocyteでのHIF(hypoxia inducing factor)-1の役割2010

    • Author(s)
      高柳猛彦、祖父江和哉、他
    • Organizer
      第37回日本集中治療医学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 敗血症におけるastrocyteでのHIF(hypoxia inducing factor)-1の役害2010

    • Author(s)
      高柳猛彦, ら
    • Organizer
      第37回日本集中治療医学会学術集会
    • Place of Presentation
      広島(リーガロイヤルホテル広島)
    • Year and Date
      2010-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット敗血症モデルの副腎におけるアクアポリン(AQP)の発見2009

    • Author(s)
      高柳猛彦
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸ポートピアホテル 神戸国際展示場(神戸)
    • Year and Date
      2009-08-17
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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