| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Systemic shock manifested as a symptom of sepsis and tabaco smoking disturb physiological homeostasis and induces phothophysiological changes in epithelium, interstitial tissue and capillary vessels of pulmonary alveoli as a unit of gas exchange. To review these pathological phenomena from the point of signal transduction and gene expression elicited by systemic and tissue hypoxia and understand molecular mechanisms behind the phenomena, we analysed cells and mice adopting methodology of molecular biology in relation to hypoxia-inducible factor 1 activity.
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