Evaluation of neuroendocrine in primary afferent neuron of neuropathic pain
| Project/Area Number |
21592020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagoya City University |
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Principal Investigator |
SUGIURA Takeshi 名古屋市立大学, 大学院・医学研究科, 講師 (20295611)
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| Co-Investigator(Kenkyū-buntansha) |
SOBUE Kazuya 名古屋市立大学, 大学院・医学研究科, 教授 (90264738)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | パッチクランプ / 後根神経節 / 侵害受容器 / サーモグラフィー |
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| Research Abstract |
Behavior tests, which study on hypersensitivity to thermal stimulation, have indicated the effect of water in CCI model. Primary afferent neurons innervated to mouse hind-paw were labeled and discriminated by using DiI. Capsaicin sensitivity of hind-paw neurons suggested that TRPV1 might have relatively little contribution for nociception and neurogenic inflammation. Recently, TRPA1 inhibition was reported to reduce neurogenic inflammation, which suggests that TRPA1 might be involved in neuroendocrine in primary afferents.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis2011
Author(s)
Takayanagi T, Sasaki H, Kawashima A, Mizuochi Y, Hirate H, Sugiura T, Azami T, Asai K, Sobue K
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Journal Title
JPEN J Parenter Enteral Nutr
Volume: 35(4)
Pages: 516-22
Related Report
Peer Reviewed
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