Regulation for niche formation of cancer stem cells by carcinoma-associated fibroblasts in prostate tumor

• Project/Area Number: 21592039
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Mie University
• Principal Investigator: ARIMA Kiminobu 三重大学, 大学院・医学系研究科, 准教授 (10175995)
• Co-Investigator(Kenkyū-buntansha): SOGA Norihito 三重大学, 医学部附属病院, 講師 (60332714) ; ISHII Kenichiro 三重大学, 大学院・医学系研究科, 助教 (90397513)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 前立腺癌幹細胞 / 癌間質 / 線維芽細胞 / 初代培養 / 共培養 / TGFβ1 / 前立腺癌 / アンドロゲン感受性 / VEGF / IGF-I / テネイシンC / TGFβ / IL-6 / ストローマ細胞 / LNCaP / 3次元培養 / αSMA

Research Abstract

In the tumor microenvironment, carcinoma-associated fibroblasts(CAF_s) are considered to play a critical role in the niche formation of cancer stem cells. To understand how CAF_s are generated during primary cancer progression, we investigated the biochemical characteristics of normal human prostate stromal cells(P_rSC) co-cultured with human prostate cancer(PC_a) cells in vitro. Our results have demonstrated that normal fibroblasts co-cultured with cancer cells become activated and exhibit biochemical characteristics of CAF_s in a heterogenous manner. Finally, we suggest that heterogenous induction of CAF_s-like differentiation might be strongly dependent on biochemical characteristics of adjacent cancer cells.

Research Products

• [Journal Article] Heterogeneous induction of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts by co-culturing with prostate cancer cells (2011)
  • Author(s): Ishii K, Mizokami A, Tsunoda T, Iguchi K, Kato M, Hori Y, Arima K, Namiki M, Sugimura Y
  • Journal Title: Journal of Cellular Biochemistry Volume: 112 Pages: 3604-3611
  • Peer Reviewed
• [Journal Article] Endocrinedisrupter bisphenol A increases in situ estrogen production in mouse urogenital sinus (2011)
  • Author(s): Arase S, Ishii K, Igarashi K, Aisaki K, Yoshio Y, Matsushima A, Shimohigashi Y, Arima K, Kanno J, Sugimura Y
  • Journal Title: Biology of Reproduction Volume: 84 Pages: 734-742
  • Peer Reviewed
• [Journal Article] Naftopidil, a subtype selective alpha1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma (2011)
  • Author(s): Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
  • Journal Title: Cancer Prevention Research Volume: 4 Pages: 87-96
  • Peer Reviewed
• [Journal Article] Androgen receptor W741C and T877A mutations in AIDL cells, an androgen independent subline of prostate cancer LNCaP cells (2011)
  • Author(s): Otsuka T, Iguchi K, Fukami K, Ishii K, Usui S, Sugimura Y, Hirano K
  • Journal Title: Tumor Biology Volume: 32 Pages: 1097-1102
  • Peer Reviewed
• [Journal Article] Pedicled vastus lateralis musculofascial flap as a new technique for repairing rectourethral fistula after radical prostatectomy (2011)
  • Author(s): Iwamoto Y, Kanda H, Tsuji M, Toiyama Y, Yamada Y, Soga N, Arima K, Sudo A, Kusunoki M, Sugimura Y
  • Journal Title: Microsurgery Volume: 31 Issue: 7 Pages: 564-567
  • DOI: 10.1002/micr.20923
  • Peer Reviewed
• [Journal Article] Management of renal tumors in Von Hippel-Lindau disease by percutaneous CT fluoroscopic glided radiofrequency ablation : preliminary results (2011)
  • Author(s): Iwamoto Y, Kanda H, Yamakado K, Soga N, Arima K, Takeda K, Sugimura Y
  • Journal Title: Familial Cancer Volume: 10 Pages: 529-534
  • Peer Reviewed
• [Journal Article] Heterogenous induction of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts by co-culturing with prostate cancer cells (2011)
  • Author(s): Ishii K, Mizokami A, Tsunoda T, Iguchi K, Kato M, Hori Y, Arima K, Namiki M, Sugimura Y
  • Journal Title: Journal of Cellular Biochemistry Volume: 112 Issue: 12 Pages: 3604-3611
  • DOI: 10.1002/jcb.23291
  • Peer Reviewed
• [Journal Article] Naftopidil, a selective alpha1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma (2011)
  • Author(s): Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
  • Journal Title: Cancer Prevention Research Volume: 4 Pages: 87-96
  • Peer Reviewed
• [Journal Article] Endocrine disrupter bisphenol A increases in situ estrogen production in the mouse urogenital sinus (2011)
  • Author(s): Arase S, Ishii K, Igarashi K, Aisaki K, Yoshio Y, Matsushima A, Shimohigashi Y, Arima K, Kanno J, Sugimura Y
  • Journal Title: Biology of Reproduction Volume: 84 Pages: 734-742
  • Peer Reviewed
• [Journal Article] Naftopidil, a subtype selective alphal-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. (2011)
  • Author(s): Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y.
  • Journal Title: Cancer Prevention Research Volume: 4 Pages: 87-96
  • Peer Reviewed
• [Journal Article] Structural changes in alpha1-adrenoceptor antagonist-treated human prostatic stroma (2010)
  • Author(s): Imamura T, Ishii K, Kanda H, Arase S, Yoshio Y, Hori Y, Soga N, Kise H, Arima K, Sugimura Y
  • Journal Title: Clinical and Experimental Medicine Volume: 10 Pages: 99-106
  • Peer Reviewed
• [Journal Article] Endodermal origin of bladder trigone inferred from mesenchymal-epithelial interactions (2010)
  • Author(s): Tanaka ST, Ishii K, DeMarco RT, Pope JC, Brock JW, Hayward SW
  • Journal Title: Journal of Urology Volume: 183 Pages: 386-391
  • Peer Reviewed
• [Journal Article] Effect of transforming growth factorαoverexpression on urogenital organ development in mouse (2010)
  • Author(s): Yoshio Y, Ishii K, Arase S, Hori Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
  • Journal Title: Differentiation Volume: 80 Pages: 82-88
  • Peer Reviewed
• [Journal Article] Effect of transforming growth factor α overexpression on urogenital organ development in mouse. (2010)
  • Author(s): Yoshio Y, Ishii K, Arase S, Hori Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y.
  • Journal Title: Differentiation Volume: 80 Pages: 82-88
  • Peer Reviewed
• [Journal Article] Evidence that androgen-independent stromal growth factor signals promote androgen-insensitive prostate cancer cell growth in vivo (2009)
  • Author(s): Ishii K, Imamura T, Iguchi K, Arase S, Yoshio Y, Arima K, Hirano K, Sugimura Y
  • Journal Title: Endocrine-Related Cancer Volume: 16 Pages: 415-428
  • Peer Reviewed
• [Journal Article] Adult urothelial transdifferentiation to prostate epithelia is mediated by paracrine TGF-s signaling (2009)
  • Author(s): Li X, Wang Y, Sharif-Afshar AR, Uwamariya C, Yi A, Ishii K, Hayward SW, Matusik RJ, Bhowmick NA
  • Journal Title: Differentiation Volume: 77 Pages: 95-102
  • Peer Reviewed
• [Journal Article] Evidence that androgen-independent stromal growth factor signals promote androgen-insensitive prostate cancer cell growth in vivo (2009)
  • Author(s): Ishii K, Imamura T, Iguchi K, Arase S, Yoshio Y, Arima K, Hirano K, Sugimura Y.
  • Journal Title: Endocrine-Related Cancer 16 Pages: 415-428
  • Peer Reviewed
• [Journal Article] Intermittent docetaxel therapy with estramustine for hormone-refractory prostate cancer in Japanese patients (2009)
  • Author(s): Soga N, Kato M, Nishikawa K, Hasegawa Y, Yamada Y, Kise H, Arima K, Sugimura Y.
  • Journal Title: International Journal of Clinical Oncology 14 Pages: 130-135
  • NAID: 10025147830
  • Peer Reviewed
• [Journal Article] Manserin as a novel histochemical neuroendocrine marker in prostate cancer
  • Author(s): Nishikawa K, Soga N, Ishii K, Kato M, Iwamoto Y, Hori Y, Etoh M, Ohkawara T, Yamada T, Uchida K, Kise H, Arima K, Narita M, Shiraishi T, Sugimura Y
  • Journal Title: Urologic Oncology(in press)
  • Peer Reviewed
• [Journal Article] Low androgen sensitivity is associated with low levels of Akt phosphorylation in LNCaP-E9 cells
  • Author(s): Iguchi K, Fukami K, Ishii K, Otsuka T, Usui S, Sugimura Y, Hirano K
  • Journal Title: Journal of Andrology(in press)
  • Peer Reviewed
• [Journal Article] Manserin as a novel histochemical neuroendocrine marker in prostate cancer
  • Author(s): Nishikawa K, Soga N, Ishii K, Kato M, Iwamoto Y, Hori Y, Etoh M, Ohkawara T, Yamada T, Uchida K, Kise H, Arima K, Narita M, Shiraishi T, Sugimura Y
  • Journal Title: Urologic Oncology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Endocrine disrupter bisphenol A increases in situ estrogen production in mouse urogenital sinus.
  • Author(s): Arase S, Ishii K, Igarashi K, Aisaki K, Yoshio Y, Matsushima A, Shimohigashi Y, Arima K, Kanno J, Sugimura Y.
  • Journal Title: Biology of Reproduction Volume: (in press)
  • Peer Reviewed
• [Journal Article] Structural changes in alphal-adrenoceptor antagonist-treated human prostatic stroma.
  • Author(s): Imamura T, Ishii K, Kanda H, Arase S, Yoshio Y, Hori Y, Soga N, Kise H, Arima K, Sugimura Y.
  • Journal Title: Clinical and Experimental Medicine (in press)
  • Peer Reviewed
• [Presentation] 癌間質由来インターロイキン-6による前立腺癌-間質のパラクライン・ループ活性化機構 (2012)
  • Author(s): 石井健一朗、岩本陽一、加藤学、井口和弘、溝上敦、有馬公伸、白石泰三、杉村芳樹
  • Organizer: 第21回泌尿器科分子・細胞研究会
  • Place of Presentation: 札幌市
• [Presentation] ヒト前立腺癌移植モデルにおけるα1アドレナリン受容体遮断薬が放射線感受性に与える影響 (2012)
  • Author(s): 岩本陽一、神田英輝、石井健一朗、加藤学、堀靖英、山田泰司、有馬公伸、杉村芳樹
  • Organizer: 第21回泌尿器科分子・細胞研究会
  • Place of Presentation: 札幌市
• [Presentation] 去勢後の前立腺間質リモデリングによるFGF2発現上昇が基底上皮-間質相互作用に及ぼす影響 (2012)
  • Author(s): 加藤学、石井健一朗、岩本陽一、堀靖英、山田泰司、有馬公伸、白石泰三、杉村芳樹
  • Organizer: 第21回泌尿器科分子・細胞研究会
  • Place of Presentation: 札幌市
• [Presentation] テネイシンC欠損マウス前立腺における二核細胞の出現 (2011)
  • Author(s): 石井健一朗
  • Organizer: 第1回テネイシンフォーラム
  • Place of Presentation: 津市
  • Year and Date: 2011-11-05
• [Presentation] 前立腺癌細胞株LNC_aP細胞の亜株のアンドロゲン応答性変化機序 (2011)
  • Author(s): 大塚崇史、井口和弘、深見和宏、石井健一朗、臼井茂之、杉村芳樹、平野和行
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-07-09
• [Presentation] Prostate cancer LNCaP-F10 cells are resistant against cell death induced by low pH and low nutrition culture condition (2011)
  • Author(s): Kazuhiro Iguchi, Yuri Hayakawa, Kenichiro Ishii, Kaoru Matsumoto, Shigeyuki Usui, Yoshiki Sugimura, Kazuyuki Hirano
  • Organizer: International Society for Oncological Biomarkers and Tumor Biology 2011
  • Place of Presentation: Italy, Firenze
• [Presentation] 前立腺癌-間質相互作用を標的にした新規治療戦略 (2011)
  • Author(s): 石井健一朗、堀靖英、杉村芳樹
  • Organizer: 第70回日本癌学会総会学術総会
  • Place of Presentation: 名古屋市
• [Presentation] TGF-βの長期刺激が前立腺癌細胞株に及ぼす影響とTHP-1分化マクロファージ様細胞に対する作用 (2011)
  • Author(s): 広川佳史、石井健一朗、米田操、今井裕、白石泰三
  • Organizer: 第70回日本癌学会総会学術総会
  • Place of Presentation: 名古屋市
• [Presentation] 低栄養・低pH耐性前立腺癌細胞LNC_aP-F10細胞の性状解析 (2011)
  • Author(s): 早川友里、井口和弘、石井健一朗、松本芳、臼井茂之、杉村芳樹、平野和行
  • Organizer: 第70回日本癌学会総会学術総会
  • Place of Presentation: 名古屋市
• [Presentation] Heterogeneous induction of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts by co-culturing with prostate cancer cells (2011)
  • Author(s): Kenichiro Ishii, Atsushi Mizokami, Toshiyuki Tsunoda, Kazuhiro Iguchi, Manabu Kato, Yasuhide Hori, Kiminobu Arima, Mikio Namiki, Yoshiki Sugimura
  • Organizer: 9^<th> World Congress on Urological Research
  • Place of Presentation: Austria, Innsbruck
• [Presentation] Mechanisms of prostatic structure maintenance by actions of androgen (2011)
  • Author(s): Manabu Kato, Kenichiro Ishii, Yoichi Iwamoto, Yasuhide Hori, Yasushi Yamada, Kiminobu Arima, Taizo Shiraishi, Yoshiki Sugimura
  • Organizer: 9^<th> World Congress on Urological Research
  • Place of Presentation: Austria, Innsbruck
• [Presentation] 動物モデルと前立腺増殖機構 (2011)
  • Author(s): 石井健一朗、加藤学、杉村芳樹
  • Organizer: 第30回日本アンドロロジー学会学術大会
  • Place of Presentation: 東京
• [Presentation] アンドロゲン依存的な前立腺組織構築の維持機構 (2011)
  • Author(s): 加藤学、石井健一朗、岩本陽一、堀靖英、山田泰司、曽我倫久人、有馬公伸、白石泰三、杉村芳樹
  • Organizer: 第30回日本アンドロロジー学会学術大会
  • Place of Presentation: 東京
• [Presentation] ヒト前立腺癌細胞および間質細胞に対するフェニルピペラジン誘導体の細胞周期阻害作用 (2011)
  • Author(s): 石井健一朗、堀靖英、岩本陽一、西川晃平、加藤学、神田英輝、有馬公伸、杉村芳樹
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
• [Presentation] 前立腺癌組織における新規神経内分泌物質Manserin発現の検討 (2011)
  • Author(s): 西川晃平、曽我倫久人、岩本陽一、堀靖英、石井健一朗、木瀬英明、有馬公伸、杉村芳樹
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
• [Presentation] ヒト前立腺癌間質モデルの作製と発生メカニズムの解析 (2011)
  • Author(s): 石井健一朗、溝上敦、西川晃平、岩本陽一、加藤学、曽我倫久人、木瀬英明、有馬公伸、並木幹夫、杉村芳樹
  • Organizer: 第20回泌尿器科分子・細胞研究会
  • Place of Presentation: 津市
• [Presentation] 前立腺癌組織における新規神経内分泌物質Manserin発現の検討 (2011)
  • Author(s): 西川晃平、曽我倫久人、加藤学、岩本陽一、石井健一朗、山田泰司、有馬公伸、杉村芳樹
  • Organizer: 第20回泌尿器科分子・細胞研究会
  • Place of Presentation: 津市
• [Presentation] ヒト前立腺癌細胞および間質細胞に対するフェニルピペラジン誘導体の細胞周期阻害作用 (2011)
  • Author(s): 石井健一朗、堀靖英、岩本陽一、西川晃平、加藤学、神田英輝、有馬公伸、杉村芳樹
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
• [Presentation] Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation (2010)
  • Author(s): 石井健一朗
  • Organizer: 第10回AKUA
  • Place of Presentation: 大阪市
  • Year and Date: 2010-02-12
• [Presentation] 胎生期ビスフェノールA曝露による前立腺の異常増殖機構 (2010)
  • Author(s): 石井健一朗、荒瀬栄樹、吉尾裕子、杉村芳樹
  • Organizer: 第26回前立腺シンポジウム
  • Place of Presentation: 品川
• [Presentation] Heterogeneity of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts (2010)
  • Author(s): 石井健一朗、堀靖英、溝上敦、山田泰司、有馬公伸、並木幹夫、杉村芳樹
  • Organizer: 第69回日本癌学会総会学術総会
  • Place of Presentation: 大阪市
• [Presentation] Phenylpiperazine derivatives induce G1 cell cycle arrest in human prostate cancer cells and stromal cells (2010)
  • Author(s): 堀靖英、石井健一朗、山田泰司、有馬公伸、杉村芳樹
  • Organizer: 第69回日本癌学会総会学術総会
  • Place of Presentation: 大阪市
• [Presentation] Experimental approach targeting tumor-stromal interactions in prostate cancer microenvironment (2010)
  • Author(s): 杉村芳樹、石井健一朗
  • Organizer: 第69回日本癌学会総会学術総会
  • Place of Presentation: 大阪市
• [Presentation] Characterization of androgen-low sensitive LNCaP subline, LNCaP-E9 cells (2010)
  • Author(s): Kazuhiro Iguchi, Kazuhiro Fukami, Kenichiro Ishii, Shigeyuki Usui, Yoshiki Sugimura, Kazuyuki Hirano
  • Organizer: 38^<th> Congress of the International Society of Oncology and Biomarkers(ISOBM)
  • Place of Presentation: Munchen
• [Presentation] 胎生期ビスフェノールA曝露による前立腺の異常増殖機構 (2010)
  • Author(s): 石井健一朗
  • Organizer: 第3回前立腺生物学シンポジウム
  • Place of Presentation: 鳥羽市
• [Presentation] Biological effects of fetal exposure to bisphenol A on urogenital sinus (2010)
  • Author(s): Kenichiro Ishii, Shigeki Arase, Yuko Yoshio, Katsuhide Igarashi, Kenichi Aisaki, Yasuhide Hori, Kohei Nishikawa, Norihito Soga, Hideaki Kise, Kiminobu Arima, Jun Kanno, Yoshiki Sugimura
  • Organizer: The 2010 American Urological Association(AUA) Annual Meeting
  • Place of Presentation: San Francisco
• [Presentation] Unique growth-inhibitory effects of subtype selectiveα1-adrenoceptor antagonists on human prostate cancer cells (2010)
  • Author(s): Yasuhide Hori, Kenichiro Ishii, Hideki Kanda, Kohei Nishikawa, Yuko Yoshio, Norihito Soga, Hideaki Kise, Kiminobu Arima, Yoshiki Sugimura
  • Organizer: The 2010 American Urological Association(AUA) Annual Meeting
  • Place of Presentation: San Francisco
• [Presentation] 前立腺基底上皮細胞の生物学的特性:増殖因子と性ホルモンの影響 (2010)
  • Author(s): 吉尾裕子、石井健一朗、堀靖英、西川晃平、曽我倫久人、木瀬英明、有馬公伸、杉村芳樹
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
• [Presentation] α1aアドレナリン受容体選択性遮断薬Silodosinによる癌微小環境を標的とした前立腺癌増殖抑制メカニズム (2010)
  • Author(s): 堀靖英、石井健一朗、神田英輝、西川晃平、吉尾裕子、曽我倫久人、木瀬英明、有馬公伸、杉村芳樹
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
• [Presentation] エストロゲン様化学物質誘導性マウス前立腺基底上皮細胞の異常増殖におけるEGFRリガンドの作用 (2010)
  • Author(s): 吉尾裕子、石井健一朗、堀靖英、西川晃平、曽我倫久人、木瀬英明、有馬公伸、杉村芳樹
  • Organizer: 第19回泌尿器科分子・細胞研究会
  • Place of Presentation: 神戸市
• [Presentation] サブタイプ選択性α1アドレナリン受容体遮断薬による受容体非依存的な前立腺癌増殖抑制作用 (2010)
  • Author(s): 堀靖英、石井健一朗、神田英輝、西川晃平、吉尾裕子、曽我倫久人、木瀬英明、有馬公伸、杉村芳樹
  • Organizer: 第19回泌尿器科分子・細胞研究会
  • Place of Presentation: 神戸市
• [Presentation] Heterogeneity of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts (2010)
  • Author(s): 石井健一朗、堀靖英、溝上敦、山田泰司、有馬公伸、並木幹夫、杉村芳樹
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 癌間質を標的にした再燃前立腺癌に対する新規治療戦略 (2009)
  • Author(s): 石井健一朗
  • Organizer: 第4回Basic Urology Research Seminar
  • Place of Presentation: 浅草
  • Year and Date: 2009-08-22
• [Presentation] 前立腺間質、正常上皮および癌間質間のネットワーク構成の比較-前立腺癌フィールドエフェクトの解析- (2009)
  • Author(s): 角田俊之、石井健一朗、杉村芳樹、内藤誠二
  • Organizer: 第25回前立腺シンポジウム
  • Place of Presentation: 品川
• [Presentation] Biological effects of fetal exposure to bisphenol A on urogenital sinus (2009)
  • Author(s): Kenichiro Ishii, Shigeki Arase, Katsuhide Igarashi, Kenichi Aisaki, Yuko Yoshio, Yasuhide Hori, Kohei Nishikawa, Norihito Soga, Hideaki Kise, Kiminobu Arima, Jun Kanno, Yoshiki Sugimura
  • Organizer: 19th Annual Fall Meeting of the Society for Basic Urologic Research
  • Place of Presentation: New Orleans
• [Presentation] Carcinoma-associated fibroblast-like differentiation of normal human prostatic fibroblasts (2009)
  • Author(s): 石井健一朗,角田俊之,堀靖英,山田泰司,有馬公伸,杉村芳樹
  • Organizer: 第68回日本癌学会総会学術総会
  • Place of Presentation: 横浜市
• [Presentation] Unique growth-inhibitory effects of subtype selective alpha1-adrenoceptor antagonists on human prostate cancer cells (2009)
  • Author(s): 堀靖英,石井健一朗,山田泰司,有馬公伸,杉村芳樹
  • Organizer: 第68回日本癌学会総会学術総会
  • Place of Presentation: 横浜市
• [Presentation] ホルモン依存性喪失ヒト前立腺癌細胞モデルを用いた再燃前立腺癌の増殖メカニズム解析 (2009)
  • Author(s): 石井健一朗、井口和弘、深見和宏、吉尾裕子、堀靖英、西川晃平、曽我倫久人、木瀬英明、有馬公伸、平野和行、杉村芳樹
  • Organizer: 第28回日本アンドロロジー学会学術大会
  • Place of Presentation: 富山市
• [Presentation] Stromal tenascin-C signal regulates mouse prostatic development and epithelial cell differentiation (2009)
  • Author(s): Kenichiro Ishii, Kyoko Imanaka-Yoshida, Tetsuya Imamura, Shigeki Arase, Yuko Yoshio, Yasuhide Hori, Kiminobu Arima, Toshimichi Yoshida, Yoshiki Sugimura
  • Organizer: The 2009 American Urological Association(AUA) Annual Meeting
  • Place of Presentation: Chicago
• [Presentation] A new therapeutic strategy for targeting tumor stroma in hormone-refractory prostate cancer cell growth under androgen ablation therapy (2009)
  • Author(s): Kenichiro Ishii, Tetsuya Imamura, Kazuhiro Iguchi, Shigeki Arase, Yuko Yoshio, Yasuhide Hori, Kiminobu Arima, Kazuyuki Hirano, Yoshiki Sugimura
  • Organizer: The 2009 American Urological Association(AUA) Annual Meeting
  • Place of Presentation: Chicago
• [Presentation] TGFα過発現マウス前立腺の病理組織学的解析 (2009)
  • Author(s): 石井健一朗、吉尾裕子、荒瀬栄樹、今村哲也、堀靖英、有馬公伸、杉村芳樹
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山市
• [Presentation] マウスゼノグラフトモデルを用いた前立腺肥大症組織に対する各種薬剤の影響評価 (2009)
  • Author(s): 今村哲也、石井健一朗、荒瀬栄樹、吉尾裕子、堀靖英、曽我倫久人、木瀬英明、有馬公伸、杉村芳樹
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山市
• [Presentation] ビスフェノールA経胎盤曝露によりマウス泌尿生殖洞で発現変動する性分化関連遺伝子群の同定 (2009)
  • Author(s): 荒瀬栄樹、石井健一朗、五十嵐勝秀、相崎健一、小倉友二、今村哲也、吉尾裕子、有馬公伸、菅野純、杉村芳樹
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山市
• [Presentation] A new therapeutic strategy for targeting tumor stroma in hormone-refractory prostate cancer cell growth under androgen ablation therapy (2009)
  • Author(s): Ishii K, Imamura T, Iguchi K, Arase S, Yoshio Y, Hori Y, Arima K, Hirano K, Sugimura Y.
  • Organizer: The 2009 American Urological Association (AUA) Annual Meeting
  • Place of Presentation: Chicago, IL, USA
• [Remarks] 三重大学大学院医学系研究科腎泌尿器外科学
  • URL: http://www.medic.mie-u.ac.jp/urology/