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Impact of Nocturia on Bone Fracture and Mortality in Older Individuals : A Japanese Longitudinal Cohort Study

Research Project

Project/Area Number 21592064
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTohoku University

Principal Investigator

NAMIMA Takashige  東北大学, 大学院・医学系研究科, 非常勤講師 (70282069)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Haruo  東北大学, 病院, 講師 (80333574)
KAIHO Yasuhiro  東北大学, 病院, 助教 (30447130)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords高齢者 / 夜間頻尿 / 疫学調査 / 死亡率 / 骨折 / 転倒
Research Abstract

We evaluated the association of nocturia with fracture and death in a large, community based sample of Japanese individuals 70 years old or older. We compared the risk of bone fracture and death with or without nocturia in a multivariate Cox proportional hazard model. For all fractures with nocturia the HR was 2. 01 (95%CI 1. 04-3. 87). The mortality rate in individuals with nocturia was significantly higher than in those without nocturia. For mortality in patients with nocturia \adjusted HR was 1. 98 (95%CI 1. 09-3. 59, p=0. 03). During a 5-year observation period elderly individuals with nocturia were at greater risk for fracture and death than those without nocturia.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (50 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 1 results) Presentation (20 results) Book (4 results) Remarks (19 results)

  • [Journal Article] 【排尿障害UPDATE】高齢者の夜間頻尿がもたらす影響について2011

    • Author(s)
      中川晴夫、海法康裕、荒井陽一
    • Journal Title

      UROLOGY TODAY

      Volume: Vol.18 No.3 Pages: 142-146

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Impact of nocturia on bone fracture and mortality in older individuals : a Japanese longitudinal cohort study2010

    • Author(s)
      Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K, Nakaya N, Kuriyama S, Ebihara S, Nagatomi R, Tsuji I, Arai Y
    • Journal Title

      J Urol

      Volume: 184(4) Pages: 1413-1418

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【夜間頻尿Update :もう外来で困らない】夜間頻尿と転倒骨折・死亡リスク2010

    • Author(s)
      中川晴夫, 海法康裕, 池田義弘, 荒井陽一
    • Journal Title

      Urology View

      Volume: 8巻3号 Pages: 96-99

    • Related Report
      2011 Final Research Report
  • [Journal Article] Impact of nocturia on bone fracture and mortality in older individuals : a Japanese longitudinal cohort study.2010

    • Author(s)
      Nakagawa H, et. al
    • Journal Title

      Journal of Urology

      Volume: 184(4) Pages: 1413-1418

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 夜間頻尿と転倒骨折・死亡リスク2010

    • Author(s)
      中川晴夫, 他
    • Journal Title

      Urology View

      Volume: 8(3) Pages: 96-99

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 泌尿器科疾患の薬物治療夜間頻尿2009

    • Author(s)
      中川晴夫
    • Journal Title

      薬事新報

      Volume: 2579 Pages: 9-14

    • Related Report
      2011 Final Research Report
  • [Journal Article] 夜間頻尿2009

    • Author(s)
      中川晴夫
    • Journal Title

      薬事新報

      Volume: 2579 Pages: 9-14

    • Related Report
      2009 Annual Research Report
  • [Presentation] パネルディスカッション:「高齢者の夜間頻尿をめぐる諸問題」2012

    • Author(s)
      中川晴夫、浪間孝重
    • Organizer
      24時間在宅ケア研究会横浜フォーラム
    • Place of Presentation
      横浜市
    • Year and Date
      2012-01-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 夜間頻尿と高齢者の転倒との関連について-24時間在宅ケアにおける調査結果-2011

    • Author(s)
      中川晴夫、熊井カホル、川守田直樹、泉秀明、海法康裕、荒井陽一
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      福井市
    • Year and Date
      2011-09-25
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] シンポジウム1:夜間頻尿、特に夜間多尿に注目して:新たなエビデンスと治療の展望「夜間頻尿の疫学」2011

    • Author(s)
      中川晴夫
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      福井市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] シンポジウムE:夜間頻尿等排泄障害と対応「高齢者の夜間頻尿」2011

    • Author(s)
      中川晴夫
    • Organizer
      第12回日本認知症ケア学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ランチョンセミナー「疫学調査から見た高齢者の夜間頻尿の意義」2011

    • Author(s)
      中川晴夫
    • Organizer
      第24回老年泌尿器科学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 疫学調査から見た高齢者の夜間頻尿の意義2011

    • Author(s)
      中川晴夫
    • Organizer
      第24回老年泌尿器科学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特別講演「夜間頻尿がもたらすこと-疫学調査からの報告-」2011

    • Author(s)
      中川晴夫
    • Organizer
      第7回夜間頻尿を考える会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-02-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 高齢者の夜間頻尿をめぐる諸問題2010

    • Author(s)
      中川晴夫
    • Organizer
      24時間在宅ケア研究会 横浜フォーラム
    • Place of Presentation
      横浜市
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「高齢者の夜間頻尿をめぐる諸問題」2010

    • Author(s)
      中川晴夫、浪間孝重
    • Organizer
      24時間在宅ケア研究会盛岡フォーラム
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Epidemiological Aspect of Nocturia : Increase in Mortality and Fractures2010

    • Author(s)
      Nakagawa H. Namima T
    • Organizer
      Japan Korea Urological Congress
    • Place of Presentation
      (Kyoto Japan)(Luncheon Seminar)
    • Year and Date
      2010-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Epidemiological Aspect of Nocturia : Increase in Mortality and Fractures(Luncheon Seminar)2010

    • Author(s)
      NAKAGAWA H
    • Organizer
      27^<th> Japan Korea Urological Congress
    • Place of Presentation
      Kyoto Japan
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] mpact of Nocturia on Fractures and Mortality in Older Population : Correlates with the Night-Time Frequency?2010

    • Author(s)
      Nakagawa H, Niu K, Hozawa A, Kaiho Y, Ikeda Y, Imanishi R, Miyazato M, Nagatomi R, Tsuji I, Arai Y
    • Organizer
      International Continence Society 39^th Annual Meeting
    • Place of Presentation
      (Toronto CANADA), discussion poster
    • Year and Date
      2010-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] GREEN TEA CONSUMPTION IS ASSOCIATED WITH NOCTURIA IN A JAPANESE ELDERLY POPULATION2010

    • Author(s)
      Miyazato, Nakagawa, et al
    • Organizer
      International Continence Society 39^<th> Annual Meeting
    • Place of Presentation
      Toronto CANADA
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] IMPACT OF NOCTURIA ON FRACTURES AND MORTALITY IN OLDER POPULATION : CORRELATES WITH THE NIGHT-TIME FREQUENCY?2010

    • Author(s)
      NAKAGAWA, et al
    • Organizer
      Irrternational Contirrence Society 39^<th> Annual Meeting
    • Place of Presentation
      Toronto CANADA
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mortality in the elderly correlates with the frequency of nighttime voiding : Result of a 5-year prospective cohort study in Japan2010

    • Author(s)
      Nakagawa H, Niu K, Kaiho Y, Ohmori-Matsuda K, Nakaya N, Nagatomi R, Tsuji I Arai Y
    • Organizer
      American Urological Association Annual Meeting
    • Place of Presentation
      San Francisco USA modulated poster session
    • Year and Date
      2010-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Mortality in the elderly correlates with the frequency of nighttime voiding : Result of a 5-year prospective cohort study in Japan.2010

    • Author(s)
      NAKAGAWA, et al
    • Organizer
      American Urology Association Annual Meeting
    • Place of Presentation
      San Francisco USA
    • Year and Date
      2010-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高齢者の夜間排尿回数と死亡率との関連高齢者の疫学調査からの5年間の前向きコホートによる解析2010

    • Author(s)
      中川晴夫, 海法康裕, 浪間孝重, 池田義弘, 牛凱軍, 寶沢篤, 永富良一, 辻一郎, 荒井陽一
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-04-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of nocturia on medical care use and its costs in an elderly population : 30 month prospective observation of national health insurance beneficiaries in Japan.2009

    • Author(s)
      NAKAGAWA, et al
    • Organizer
      American Urology Association Annual Meeting
    • Place of Presentation
      San Francisco USA
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高齢者の医療費・入院日数と夜間頻尿との関連 国民健康保険からの前向き調査2009

    • Author(s)
      中川晴夫, 他
    • Organizer
      第16回日本排尿機能学会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association between Nocturia and mortality in a Community-dwelling Elderly Population Aged 70 Years and Over : Results of a 3-year prospective cohort study in Japan2009

    • Author(s)
      Nakagawa HNakagawa HNakagawa H Nakagawa HNakagawa HNakagawa HNakagawa HNakagawa HNakagawa H, Niu K, Kaiho Y, Nakaya N, Ohmori-Matsuda K, Imanishi R, Nagatomi R, Tsuji I Arai Y. Arai Y. Arai Y. Arai Y. Arai Y
    • Organizer
      American Urological Association Annual Meeting
    • Place of Presentation
      Chicago Illinois modulated poster session
    • Year and Date
      2009-04-25
    • Related Report
      2011 Final Research Report
  • [Book] ケアマネージャーに必要な疾患の知識と活用2012

    • Author(s)
      中川晴夫
    • Related Report
      2011 Final Research Report
  • [Book] The Journal of Urology 日本語版 ELSEVIER2011

    • Author(s)
      akagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y
    • Total Pages
      27
    • Related Report
      2011 Final Research Report
  • [Book] 第7回夜間頻尿を考える会記録集2011

    • Author(s)
      中川晴夫、海法康裕、浪間孝重、荒井陽一
    • Related Report
      2011 Final Research Report
  • [Book] Bottomline Health p12009

    • Author(s)
      Nakagawa H
    • Total Pages
      9
    • Related Report
      2011 Final Research Report
  • [Remarks] 新聞報道1. 2009. 5. 21 Medical Tribune 42(24):24中川晴夫:排尿ケアには職種間の連携が不可欠「排尿ケアでも病態の評価が重要」

    • Related Report
      2011 Final Research Report
  • [Remarks] 2. 2010.1. 17日本経済新聞14面健康「夜間頻尿年のせい?」

    • Related Report
      2011 Final Research Report
  • [Remarks] 3. 2010.4. 3朝日新聞家庭面「元気のひけつ気を付けよう, 夜中のおしっこ」

    • Related Report
      2011 Final Research Report
  • [Remarks] 4. 2010.5. 2朝日新聞26面「夜のおしっこ多いと危険? 高齢者死亡率上がる傾向」

    • Related Report
      2011 Final Research Report
  • [Remarks] 5. 2012. 1. 13読売新聞20面いきいき健康生活「夜間頻尿、水分調節を」

    • Related Report
      2011 Final Research Report
  • [Remarks] テレビ報道1. 2011. 10.30体の気持ちTBS夜間頻尿と骨折との関連資料提供

    • Related Report
      2011 Final Research Report
  • [Remarks] 2. 2012. 3. 27 NHKゆうどきネットワーク「夜間頻尿」資料提供

    • Related Report
      2011 Final Research Report
  • [Remarks] 1. Nocturia Associated With Increased Mortality Risk : Presented at AUA June 1, 2010 Doctor's Guide Channels

    • URL

      http://www.docguide.com/news/content.nsf/news/852576140048867C85257735007AEDF5

    • Related Report
      2011 Final Research Report
  • [Remarks] 2. AUA : Nocturia Linked to Increased Risk of Mortality May 31, 2010 Modern Medicine

    • URL

      http://www.modernmedicine.com/modernmedicine/Modern+Medicine+Now/AUA-Nocturia-Linked-to-Increased-Risk-of-Mortality/ArticleNewsFeed/Article/detail/672136

    • Related Report
      2011 Final Research Report
  • [Remarks] 3. Frequent Urination at Night Linked to Raised Death Risk May 30 2010 HealthDay News.

    • Related Report
      2011 Final Research Report
  • [Remarks] 4. Health Watch : Frequent Urination at Night Linked to Raised Death Risk May 31, 2010 The Jacksonville Obesrver

    • Related Report
      2011 Final Research Report
  • [Remarks] 5. Frequent Urination at Night Linked to Raised Death Risk Jun 01, 2010 All Refer. com health

    • URL

      http://health.allrefer.com/news/20100530639552/frequent-urination-at-night-linked-to-raised-death-risk.html

    • Related Report
      2011 Final Research Report
  • [Remarks] 6. Frequent Urination at Night Linked to Raised Death Risk May. 31, 2010 azcentral. com

    • URL

      http://www.azcentral.com/health/news/articles/2010/05/30/20100530frequent-urination-at-night-linked-to-raised-death-risk.html

    • Related Report
      2011 Final Research Report
  • [Remarks] 7. Nightly Bathroom Trips May Signal Early Death MAY 30, 2010 AOL Health

    • URL

      http://www.aolhealth.com/condition-center/bladder-conditions/urinating-frequently-may-cause-early-death

    • Related Report
      2011 Final Research Report
  • [Remarks] 8. Mortality May 31 2010 Skyscape

    • Related Report
      2011 Final Research Report
  • [Remarks] 9. Frequent Urination at Night Linked to Raised Death Risk MAY 30, 2010 AOL Health my OptumHealth. com

    • URL

      http://www.myoptumhealth.com/portal/NewsArchive/item/Frequent+Urination+at+Night+Linked+to+R

    • Related Report
      2011 Final Research Report
  • [Remarks] 10.Frequent Urination at Night Linked to Raised Death Risk May 30 2010 University of Minnesota Medical Center, Fairview

    • Related Report
      2011 Final Research Report
  • [Remarks] 11. Frequent Urination at Night Linked to Raised Death Risk May 30 2010 COR MEDICAL GROUP

    • Related Report
      2011 Final Research Report
  • [Remarks] 12. Frequent Urination at Night Linked to Raised Death Risk 1 June 2010 UroSourse

    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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