The role of adiponectin and resistin in the pathogenesis of postmenopausal metabolic syndrome
| Project/Area Number |
21592142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SATOH Hiroaki 福島県立医科大学, 医学部, 准教授 (20323595)
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| Co-Investigator(Kenkyū-buntansha) |
MIDORIKAWA Sanae 福島県立医科大学, 医学部, 講師 (10325962)
WATANABE Tsuyoshi 福島県立医科大学, 医学部, 講師 (80158641)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 更年期医学 / インスリン抵抗性 / アディポサイトカイン / 糖尿病 / 動物 / シグナル伝達 |
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| Research Abstract |
To investigate the physiological role of Adipo and Res in the postmenopausal, estrogen-deficient state, we studied the chronic in vivo effect of Adipo and Res on insulin sensitivity in young ovariectomized female Wistar rats. Estrogen-deficient state had significantly increased body weight and decreased insulin sensitivity. Adiponectin improves the estrogen deficiency induced insulin resistance, whereas resistin exacerbates the estrogen deficiency induced insulin resistance. Furthermore, we found that AMPK is a key molecule player in muscle and liver.
These results that the insulin resistance has been involved in the incidence of diabetes increases as women age, especially after menopause.
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Report
(4 results)
Research Products
(57 results)
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[Presentation] 2型糖尿病患者におけるヤーコンの糖代謝に及ぼす影響についての検討2012
Author(s)
佐藤博亮, 工藤明宏, 平井裕之, 長谷川浩司, 藤原淳, 菅谷芳幸, 待井典剛, 山崎聡, 渡邉聡子, 中嶋真一, 緑川早苗, 渡辺毅
Organizer
第15回日本病態栄養学会年次学術集会
Place of Presentation
京都府京都市
Related Report
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[Presentation] The High Potassium Intake Improves High Fat Diet Induced Insulin Resistance in Male Wistar Rats.2011
Author(s)
Satoh H, Sugaya Y, Kudoh A, Yamazaki S, Machii N, Watanabe S, Hirai H, Hasegawa K, Nakajima S, Midorikawa S, Watanabe T.
Organizer
71^<st> American Diabetes Association Scientific Sessions
Place of Presentation
San Diego CA
Related Report
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[Presentation] The High Potassium Intake Improves High Fat Diet Induced Insulin Resistance in Male Wistar Rats.(1712-P)2011
Author(s)
Satoh H, Sugaya Y, Kudoh A, Yamazaki S, Machii N, Watanabe S, Hirai H, Hasegawa K, Nakajima S, Midorikawa S, Watanabe T
Organizer
71^<th> American Diabetes Association Scientific Sessions
Place of Presentation
San Diego, CA, USA
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[Presentation] Impairment of insulin sensitivity via reactive oxygen species in muscle cells2010
Author(s)
Kudoh A, Satoh H, Hirai H, Yamazaki S, Sugaya Y, Machii N, Hasegawa K, Watanabe S, Nakajima S, Midorikawa S, Watanabe T.
Organizer
第42回日本動脈硬化学会総会・学術集会
Place of Presentation
岐阜県岐阜市
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[Presentation] Amenorrhea resulting from polycystic ovary syndrome(PCOS) secondary to growth hormone(GH) producing pituitary adenoma2010
Author(s)
Watanabe S, Midorikawa S, Sugaya Y, Honma M, Machii N, Hirai H, Kudoh A, Hasegawa K, Fujiwara F, Nakajima N, Satoh H, Watanabe T.
Organizer
14^<th> International Congress of Endocrinology(ICE2010)
Place of Presentation
Kyoto
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[Presentation] Comparison two kinds of PPAR_γ agonist, pioglitazone or telmisartan, on circulating total adiponectin and its multimer distribution in patients with type 2 diabetes2010
Author(s)
Satoh H, Kudoh K, Hirai H, Yamazaki S, Hasegawa K, Fujiwara F, Watanabe S, Sugaya Y, Machii N, Honma M, Nakajima S, Midorikawa S, Watanabe T
Organizer
14^<th> International Congress of Endocrinology(ICE2010)
Place of Presentation
Kyoto, JAPAN
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[Presentation] The Mechanisms by which Pioglitazone Improves Insulin Sensitivity and Increases Body Weight in Patients with Type 2 Diabetes Mellitus2009
Author(s)
Hirai H, Satoh H, Kudoh A, Hasegawa K, Yamazaki S, Sugaya Y, Fujiwara M, Honma M, Nakajima S, Midorikawa S, Watanabe T
Organizer
69^<th> American Diabetes Association Scientific Sessions
Place of Presentation
New Orleans, LA
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[Presentation] Adenovirus-mediated chronic expression of adiponectin improves early stage diabetic nephropathy in STZ induced diabetic Wistar rats2009
Author(s)
Satoh H, Nakamaki S, Kudoh A, Hirai H, Yamazaki S, Sugaya Y, Hasegawa K, Fujiwara M, Honma M, Nakajima S, Midorikawa S, Watanabe T
Organizer
69^<th> American Diabetes Association Scientific Sessions
Place of Presentation
New Orleans, LA
Related Report
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[Presentation] Adenovirus-mediated chronic expression of adiponectin improves early stage diabetic nephropathy in STZ induced diabetic Wistar rats.2009
Author(s)
Hiroaki Satoh, Shintaro Nakamaki, Akihiro Kudoh, Hiroyuki Hirai, Satoru Yamazaki, Yoshiyuki Sugaya, Koji Hasegawa, Makoto Fujiwara, Miyuki Honma, Shinichi Nakajima, Sanae Midorikawa, Tsuyoshi Watanabe
Organizer
69^<th> American Diabetes Association Scientific Sessions.
Place of Presentation
New Orleans, LA, USA
Related Report
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[Presentation] The Mechanisms by which Pioglitazone Improves Insulin Sensitivity and Increases Body Weight in Patients with Type 2 Diabetes Mellitus.2009
Author(s)
Hiroyuki Hirai, Hiroaki Satoh, Akihiro Kudoh, Koji Hasegawa, Satoru Yamazaki, Yoshiyuki Sugaya, Makoto Fujiwara, Miyuki Honma, Shinichi Nakajima, Sanae Midorikawa, Tsuyoshi Watanabe.
Organizer
69^<th> American Diabetes Association Scientific Sessions.
Place of Presentation
New Orleans, LA, USA
Related Report
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