| Project/Area Number |
21592171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HONDA Akira 独立行政法人理化学研究所, 感覚器官発生研究チーム, 研究員 (50443023)
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| Co-Investigator(Kenkyū-buntansha) |
KITA Tomoko 独立行政法人理化学研究所, 感覚器官発生研究チーム, 研究員 (20362519)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内耳発生 / 内耳機能 / 有毛細胞 / 内耳神経 / 血管条 / 内耳神経発生 / 転写制御 / ニューロフィラメント / CASK |
|---|
| Research Abstract |
Calcium/calmodulin-dependent serine kinase(CASK) plays an important role in brain development, and in patients with CASK mutations sensorineural hearing loss was observed. However, there has been no comprehensive study of CASK in the inner ear. To better understand the physiological importance of CASK, we examined the expression pattern of CASK in chick and mouse inner ear. We observed the expression of CASK in the hair cell(HC), the spiral ganglion(SG) neurons, and in the stria vascularis(SV). Analysis of CASK-binding protein identified some nuclear proteins, and the molecules required for membrane trafficking events. The cochlea from CASK conditional KO mice shows a clear defect with a decrease in the number of SG neurons and the morphology is disturbed. The data suggests that CASK is required for the formation and/or function of HC, SG neurons, and SV.
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