Role of Epithelial Mesenchymal Transition on the Pathogenesis of Dry Eye Disease in SOD1 Knock Out Mice

Research Project

Project/Area Number	21592245
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Ophthalmology
Research Institution	Keio University
Principal Investigator	NEGISHI Kazuno 慶應義塾大学, 医学部, 准教授 (10228281)
Co-Investigator(Renkei-kenkyūsha)	MURAT Dogru 慶應義塾大学, 医学部, 特任准教授 (60385284)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	ドライアイ / 老化 / ストレス / 酸化ストレス / 涙腺 / 上皮間葉移行
Research Abstract	In the Cu, Zn-superoxide dismutase knock out mice(Sod1-/-mice), decreased tear secretion and ocular surface abnormalities were observed. Moreover, prominent fibrosis, inflammation and increased odidative stress marker staining were found in Sod1-/-mice. The current study revealed that the epithelial-mesenchymal transition could be involved in the histological changes in Sod1-/-mice.

Report

(4 results)